Coxph analysis Adi C1A-C1B

Result

Analysis details

Demographic information

load("/mnt/data/lab/gmt_data/data_brain/gmt_analysis/compare_mouse_signatures_with_human/annotation_gbm_lgg_July2021.RData")
colnames(ann3)[1]<-"Samples"

annotation_mut<-ann3[ann3$type%in%"LGG" & (ann3$IDH1==1 | ann3$IDH2==1)  & (ann3$TP53==1 & ann3$ATRX==1),]
print(paste("The number of samples LGG with IDH*, TP53, ATRX is:",nrow(annotation_mut)))

## [1] "The number of samples LGG with IDH*, TP53, ATRX is: 164"

annotation_only_idh<-ann3[ann3$type%in%"LGG" & (ann3$IDH1==1 | ann3$IDH2==1),]
print(paste("The number of samples LGG with IDH* is:",nrow(annotation_only_idh)))

## [1] "The number of samples LGG with IDH* is: 411"

annotation_gbm_lgg<-ann3
print(paste("The number of samples LGG  and GBM:",nrow(annotation_gbm_lgg)))

## [1] "The number of samples LGG  and GBM: 794"

annotation_idh_codel_nocodel<-ann3[ann3$type%in%"LGG" & (ann3$IDH_codel_subtype=="IDHmut-codel" | ann3$IDH_codel_subtype=="IDHmut-non-codel"),]
print(paste("The number of samples LGG IDHmut-codel and IDHmut-non-codel is:",nrow(annotation_idh_codel_nocodel)))

## [1] "The number of samples LGG IDHmut-codel and IDHmut-non-codel is: 414"

annotation_idh_codel<-ann3[ann3$type%in%"LGG" & (ann3$IDH_codel_subtype=="IDHmut-codel"),]
print(paste("The number of samples LGG with IDHmut-codel is:",nrow(annotation_idh_codel)))

## [1] "The number of samples LGG with IDHmut-codel is: 169"

annotation_idh_nocodel<-ann3[ann3$type%in%"LGG" & (ann3$IDH_codel_subtype=="IDHmut-non-codel"),]
print(paste("The number of samples LGG with IDHmut-non-codel is:",nrow(annotation_idh_nocodel)))

## [1] "The number of samples LGG with IDHmut-non-codel is: 245"

annotation_gbm_only<-ann3[ann3$type%in%"GBM",]
print(paste("The number of samples GBM is:",nrow(annotation_gbm_only)))

## [1] "The number of samples GBM is: 285"

Analysis

• Step1: Select the genes with cox proportional hazard models in IDH*/TP53/IATRX samples (logRank p-value < 0.05)
• Step2: Select a group of samples (e.g. IDH*/TP53/ATRX)
• Step3: Consider different tresholds of logRank 0.01,0.001,0.05
• Step4: Select the genes according with Step3
• Step5: Compute the gsva scores (default parameters) using 1) up and down genes 2) only up 3) only down
• Step6: If there is a sufficent number of genes, compute the difference between the scores computed using the up-regulated genes and down-regulated genes (up-down) (C1A is the numerator). This whati I call “global_score”.
• Step7: The stratification of the samples is perfomed using 0 as cut-off value to distinguish (MCP). The classification are stored in a column (“status_C1AC1B”).
• Step8: Plot the Kaplan Meier curve with the overall survival as outcome
• Step9: Use surv_cutpoint and column global_score to define automatically a cut-point for the groups

FAQ report

• The order of the rows is based on the logRank cut-off (0.05, 0.01, 0.01)
• First column: overall survival using manual cut-point (0) see Step7
• Second-third columns: results surv_cutpoint
• Second-third columns: results surv_cutpoint
• Table-genes: results of cox proportional hazard model with IDH*/TP53/IATRX samples (logRank p-value < 0.05). Use column logRank to select the genes.

IDH TRIPLE MUT

UP and DOWN

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UP

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DOWN

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Table genes

	Variable	Term	Beta	StandardError	Z	P	LRT	Wald	LogRank	HR	HRlower	HRupper	mm	status
36	GPR139	GPR139	5.1595162	1.0707833	4.818450	0.0000014	0.0000396	0.0000014	0.0000000	1.740802e+02	21.3450416	1.419717e+03	Gpr139	up
61	PCDHGA3	PCDHGA3	0.7508024	0.2053482	3.656241	0.0002559	0.0025701	0.0002559	0.0000236	2.118699e+00	1.4166959	3.168560e+00	Pcdhga3	up
18	CHIC2	CHIC2	1.3148603	0.3211465	4.094269	0.0000424	0.0002660	0.0000424	0.0000446	3.724231e+00	1.9846144	6.988710e+00	Chic2	down
63	PHKG1	PHKG1	-0.6406674	0.1684263	-3.803845	0.0001425	0.0002338	0.0001425	0.0001123	5.269406e-01	0.3787887	7.330378e-01	Phkg1	up
3	ADAMTS3	ADAMTS3	3.2224925	1.0514520	3.064802	0.0021781	0.0093278	0.0021781	0.0001595	2.509058e+01	3.1953107	1.970191e+02	Adamts3	up
21	CLEC18A	CLEC18A	2.8000255	0.7790372	3.594213	0.0003254	0.0014044	0.0003254	0.0001713	1.644507e+01	3.5720534	7.571001e+01	Clec18a	up
46	LIX1	LIX1	-0.6899061	0.1972237	-3.498089	0.0004686	0.0005864	0.0004686	0.0003863	5.016232e-01	0.3408007	7.383372e-01	Lix1	up
72	SFTPC	SFTPC	0.7150386	0.2109331	3.389884	0.0006992	0.0007212	0.0006992	0.0005360	2.044266e+00	1.3520438	3.090892e+00	Sftpc	up
62	PCDHGA8	PCDHGA8	5.2362662	1.6538533	3.166101	0.0015450	0.0096278	0.0015450	0.0011135	1.879670e+02	7.3505362	4.806666e+03	Pcdhga8	up
93	ZBTB8B	ZBTB8B	1.1365043	0.3520922	3.227860	0.0012472	0.0015945	0.0012472	0.0011193	3.115857e+00	1.5627018	6.212679e+00	Zbtb8b	up
48	LRRK2	LRRK2	0.5470006	0.1760081	3.107815	0.0018848	0.0038480	0.0018848	0.0016209	1.728062e+00	1.2238861	2.439932e+00	Lrrk2	up
73	SH3GL2	SH3GL2	-0.7681192	0.2405062	-3.193760	0.0014043	0.0017402	0.0014043	0.0017373	4.638847e-01	0.2895282	7.432404e-01	Sh3gl2	up
56	MYH1	MYH1	6.4885350	2.3189710	2.798023	0.0051416	0.0245868	0.0051416	0.0019006	6.575594e+02	6.9826986	6.192224e+04	Myh1	up
10	BVES	BVES	0.6492014	0.2109948	3.076860	0.0020919	0.0034852	0.0020919	0.0022376	1.914012e+00	1.2657428	2.894301e+00	Bves	up
30	FAM186B	FAM186B	3.6808737	1.2262259	3.001791	0.0026840	0.0048851	0.0026840	0.0028607	3.968105e+01	3.5877136	4.388828e+02	Fam186b	up
77	SMIM1	SMIM1	0.8812849	0.3007913	2.929889	0.0033908	0.0049659	0.0033908	0.0032167	2.414000e+00	1.3387614	4.352825e+00	Smim1	up
4	AHCYL2	AHCYL2	-0.6577339	0.2262623	-2.906954	0.0036497	0.0028521	0.0036497	0.0033225	5.180239e-01	0.3324719	8.071320e-01	Ahcyl2	up
35	GLT8D2	GLT8D2	-2.1935510	0.7573641	-2.896297	0.0037760	0.0018451	0.0037760	0.0034438	1.115200e-01	0.0252746	4.920649e-01	Glt8d2	up
16	CEP135	CEP135	0.9612037	0.3279532	2.930917	0.0033796	0.0113210	0.0033796	0.0035540	2.614842e+00	1.3749635	4.972786e+00	Cep135	down
64	PLCXD1	PLCXD1	0.7187168	0.2420552	2.969226	0.0029855	0.0042069	0.0029855	0.0038072	2.051799e+00	1.2767238	3.297407e+00	Plcxd1	up
1	ABCA8	ABCA8	0.4570804	0.1554996	2.939431	0.0032882	0.0086596	0.0032882	0.0038081	1.579456e+00	1.1645174	2.142244e+00	Abca8b	up
38	HHATL	HHATL	0.3972220	0.1379059	2.880384	0.0039719	0.0037733	0.0039719	0.0039397	1.487686e+00	1.1353391	1.949383e+00	Hhatl	up
19	CHRM5	CHRM5	1.9356194	0.6916367	2.798607	0.0051324	0.0113490	0.0051324	0.0039951	6.928334e+00	1.7861035	2.687516e+01	Chrm5	up
8	BARX2	BARX2	4.2196030	1.5075048	2.799064	0.0051251	0.0101462	0.0051251	0.0043039	6.800648e+01	3.5429083	1.305391e+03	Barx2	up
52	METTL11B	METTL11B	2.5058448	0.9684965	2.587356	0.0096716	0.0338070	0.0096716	0.0050058	1.225391e+01	1.8360684	8.178248e+01	Mettl11b	up
13	CCDC87	CCDC87	-0.6405216	0.2300130	-2.784719	0.0053574	0.0053539	0.0053574	0.0051444	5.270174e-01	0.3357666	8.272036e-01	Ccdc87	up
44	LGI3	LGI3	0.3468954	0.1262967	2.746671	0.0060204	0.0058834	0.0060204	0.0056087	1.414669e+00	1.1044621	1.812002e+00	Lgi3	up
90	TUB	TUB	-0.5353015	0.1944482	-2.752925	0.0059065	0.0069206	0.0059065	0.0057163	5.854927e-01	0.3999511	8.571092e-01	Tub	up
74	SLC35F4	SLC35F4	7.7687589	3.3957542	2.287786	0.0221500	0.0864739	0.0221500	0.0063834	2.365534e+03	3.0440926	1.838232e+06	Slc35f4	up
85	TPSAB1	TPSAB1	-0.8846744	0.3542311	-2.497450	0.0125090	0.0006903	0.0125090	0.0063899	4.128486e-01	0.2061905	8.266333e-01	Tpsb2	down
39	HHIP	HHIP	0.5059547	0.1893155	2.672548	0.0075278	0.0125895	0.0075278	0.0067012	1.658568e+00	1.1444259	2.403693e+00	Hhip	up
25	CRTAC1	CRTAC1	-0.5325153	0.2040986	-2.609107	0.0090779	0.0096375	0.0090779	0.0088457	5.871263e-01	0.3935523	8.759123e-01	Crtac1	up
32	FXYD7	FXYD7	0.2876284	0.1121605	2.564436	0.0103343	0.0106282	0.0103343	0.0093643	1.333262e+00	1.0701490	1.661065e+00	Fxyd7	up
6	AOX3P	AOX3P	11.3330802	4.4432645	2.550620	0.0107531	0.0331895	0.0107531	0.0097299	8.353995e+04	13.7968724	5.058337e+08	Aox3	up
76	SLCO4A1	SLCO4A1	0.5349134	0.2092046	2.556891	0.0105612	0.0149816	0.0105612	0.0103656	1.707300e+00	1.1330123	2.572677e+00	Slco4a1	up
91	VWC2	VWC2	-0.8658511	0.3444749	-2.513539	0.0119527	0.0076251	0.0119527	0.0104954	4.206934e-01	0.2141648	8.263865e-01	Vwc2	up
34	GLRA3	GLRA3	-0.7538191	0.3011341	-2.503267	0.0123053	0.0079996	0.0123053	0.0114512	4.705660e-01	0.2607922	8.490756e-01	Glra3	up
75	SLC8A3	SLC8A3	-0.6592973	0.2645167	-2.492460	0.0126862	0.0094084	0.0126862	0.0114866	5.172147e-01	0.3079738	8.686161e-01	Slc8a3	up
65	POPDC3	POPDC3	0.4728442	0.1902276	2.485676	0.0129306	0.0187433	0.0129306	0.0117812	1.604551e+00	1.1051763	2.329569e+00	Popdc3	up
86	TPSB2	TPSB2	-0.8013200	0.3290348	-2.435365	0.0148768	0.0022816	0.0148768	0.0118109	4.487363e-01	0.2354595	8.551968e-01	Tpsb2	down
58	NLRP6	NLRP6	0.6709421	0.2702415	2.482750	0.0130373	0.0218135	0.0130373	0.0125357	1.956079e+00	1.1517453	3.322128e+00	Nlrp6	up
60	PCDH7	PCDH7	-0.6628942	0.2660821	-2.491314	0.0127271	0.0104717	0.0127271	0.0125628	5.153577e-01	0.3059280	8.681569e-01	Pcdh7	up
24	CPA3	CPA3	-3.5762611	1.9488975	-1.835017	0.0665031	0.0007919	0.0665031	0.0136850	2.798010e-02	0.0006137	1.275716e+00	Cpa3	down
15	CDH7	CDH7	-0.8340137	0.3472870	-2.401512	0.0163275	0.0091114	0.0163275	0.0140317	4.343026e-01	0.2198777	8.578348e-01	Cdh7	up
2	ABLIM3	ABLIM3	-0.4808436	0.1974873	-2.434808	0.0148997	0.0152889	0.0148997	0.0144433	6.182616e-01	0.4198275	9.104870e-01	Ablim3	up
9	BMP3	BMP3	1.3553265	0.5709786	2.373690	0.0176113	0.0373274	0.0176113	0.0148387	3.878027e+00	1.2664643	1.187487e+01	Bmp3	up
45	LIPG	LIPG	-0.5180286	0.2142283	-2.418115	0.0156012	0.0156964	0.0156012	0.0151243	5.956937e-01	0.3914458	9.065139e-01	Lipg	up
20	CHST15	CHST15	-0.5033978	0.2093893	-2.404124	0.0162113	0.0171423	0.0162113	0.0158504	6.044733e-01	0.4010002	9.111914e-01	Chst15	up
50	MAP6D1	MAP6D1	0.3774339	0.1582533	2.384999	0.0170792	0.0189951	0.0170792	0.0161717	1.458537e+00	1.0695770	1.988946e+00	Map6d1	up
67	PPP2R2B	PPP2R2B	-0.8738006	0.3636238	-2.403035	0.0162596	0.0143470	0.0162596	0.0162598	4.173623e-01	0.2046426	8.511975e-01	Ppp2r2b	up
53	MGAT4C	MGAT4C	-1.3967395	0.5768181	-2.421456	0.0154585	0.0077684	0.0154585	0.0173673	2.474023e-01	0.0798758	7.662883e-01	Mgat4c	up
49	LUZP2	LUZP2	-0.5286152	0.2259100	-2.339937	0.0192870	0.0215066	0.0192870	0.0185859	5.894206e-01	0.3785562	9.177414e-01	Luzp2	up
22	CLMN	CLMN	0.6592381	0.2808949	2.346921	0.0189293	0.0300935	0.0189293	0.0196584	1.933319e+00	1.1148214	3.352753e+00	Clmn	up
79	SPOCK3	SPOCK3	0.5432691	0.2349925	2.311857	0.0207855	0.0283806	0.0207855	0.0197538	1.721626e+00	1.0862075	2.728756e+00	Spock3	up
70	RNF32	RNF32	-0.8573740	0.3707326	-2.312648	0.0207420	0.0208589	0.0207420	0.0203103	4.242748e-01	0.2051536	8.774358e-01	Rnf32	up
59	NSUN7	NSUN7	3.4739776	1.5269652	2.275086	0.0229008	0.0292430	0.0229008	0.0214978	3.226482e+01	1.6179837	6.434050e+02	Nsun7	up
89	TTLL7	TTLL7	0.5323731	0.2360615	2.255231	0.0241189	0.0273676	0.0241189	0.0242335	1.702969e+00	1.0721876	2.704847e+00	Ttll7	up
7	ARHGAP8	ARHGAP8	20.8761762	9.4024620	2.220288	0.0263992	0.0399771	0.0263992	0.0246239	1.165220e+09	11.5616004	1.174352e+17	Arhgap8	down
82	TGM3	TGM3	-4.2363329	1.9422468	-2.181151	0.0291723	0.0073239	0.0291723	0.0251856	1.446050e-02	0.0003213	6.507699e-01	Tgm3	up
71	SERINC2	SERINC2	0.4735774	0.2137832	2.215223	0.0267448	0.0318912	0.0267448	0.0261266	1.605728e+00	1.0560865	2.441432e+00	Serinc2	up
55	MUSK	MUSK	14.1949811	6.5867212	2.155091	0.0311547	0.0678555	0.0311547	0.0279285	1.461511e+06	3.6155532	5.907847e+11	Musk	up
12	CCDC74B	CCDC74B	-0.5455931	0.2493796	-2.187802	0.0286840	0.0294507	0.0286840	0.0283321	5.794980e-01	0.3554509	9.447659e-01	Ccdc74a	up
42	KCNG1	KCNG1	-0.4093191	0.1876366	-2.181446	0.0291504	0.0208728	0.0291504	0.0291734	6.641023e-01	0.4597465	9.592936e-01	Kcng1	up
28	FAM110B	FAM110B	-0.4469752	0.2066142	-2.163333	0.0305156	0.0322178	0.0305156	0.0297200	6.395597e-01	0.4265901	9.588517e-01	Fam110b	up
68	PRSS35	PRSS35	-0.2598632	0.1208744	-2.149861	0.0315662	0.0362531	0.0315662	0.0299232	7.711571e-01	0.6084913	9.773077e-01	Prss35	up
27	EFCAB6	EFCAB6	-4.6697434	2.1733079	-2.148680	0.0316598	0.0230073	0.0316598	0.0302239	9.374700e-03	0.0001324	6.635586e-01	Efcab6	up
40	INHBA	INHBA	-0.7294275	0.3291556	-2.216057	0.0266876	0.0184006	0.0266876	0.0302935	4.821850e-01	0.2529507	9.191606e-01	Inhba	up
80	SYT17	SYT17	-0.7200108	0.3371428	-2.135626	0.0327099	0.0303318	0.0327099	0.0319226	4.867470e-01	0.2513778	9.424965e-01	Syt17	up
26	CRYBB1	CRYBB1	-0.6315141	0.2924614	-2.159307	0.0308263	0.0275145	0.0308263	0.0323952	5.317860e-01	0.2997735	9.433667e-01	Crybb1	up
51	MEIG1	MEIG1	-1.5568552	0.7345368	-2.119506	0.0340477	0.0203682	0.0340477	0.0328155	2.107979e-01	0.0499606	8.894166e-01	Meig1	up
87	TRPC1	TRPC1	-0.9133696	0.4337654	-2.105676	0.0352325	0.0361240	0.0352325	0.0336084	4.011702e-01	0.1714379	9.387510e-01	Trpc1	up
88	TTLL11	TTLL11	1.6033388	0.7533240	2.128352	0.0333079	0.0457185	0.0333079	0.0338183	4.969597e+00	1.1352478	2.175463e+01	Ttll11	up
37	GRIA3	GRIA3	-0.5537059	0.2629723	-2.105567	0.0352420	0.0362229	0.0352420	0.0339876	5.748157e-01	0.3433098	9.624341e-01	Gria3	up
78	SPHKAP	SPHKAP	-0.3948747	0.1885112	-2.094701	0.0361976	0.0354954	0.0361976	0.0350410	6.737645e-01	0.4656365	9.749204e-01	Sphkap	up
17	CES1	CES1	-1.2365117	0.6037801	-2.047950	0.0405649	0.0117912	0.0405649	0.0353114	2.903954e-01	0.0889306	9.482620e-01	Ces1d	up
92	WNT4	WNT4	-0.8323685	0.4111895	-2.024294	0.0429399	0.0156938	0.0429399	0.0364697	4.350177e-01	0.1943130	9.738950e-01	Wnt4	up
29	FAM135B	FAM135B	-1.1288911	0.5417063	-2.083954	0.0371643	0.0296138	0.0371643	0.0366978	3.233917e-01	0.1118478	9.350398e-01	Fam135b	up
57	NIPAL3	NIPAL3	0.3346470	0.1612557	2.075257	0.0379627	0.0390300	0.0379627	0.0369967	1.397447e+00	1.0187656	1.916887e+00	Nipal3	up
14	CCL27	CCL27	-8.0296337	4.5567387	-1.762145	0.0780448	0.0069579	0.0780448	0.0373252	3.257000e-04	0.0000000	2.463074e+00	Ccl27a	up
54	MT3	MT3	0.3041427	0.1425664	2.133341	0.0328967	0.0234258	0.0328967	0.0395999	1.355462e+00	1.0250258	1.792422e+00	Mt3	up
47	LRRC6	LRRC6	-1.0838316	0.5327818	-2.034288	0.0419226	0.0388757	0.0419226	0.0396194	3.382968e-01	0.1190675	9.611754e-01	Lrrc6	up
81	TENM4	TENM4	-0.6701993	0.3295016	-2.033979	0.0419538	0.0392560	0.0419538	0.0413113	5.116066e-01	0.2682031	9.759070e-01	Tenm4	up
5	ALDOC	ALDOC	-0.3064586	0.1514231	-2.023857	0.0429849	0.0525149	0.0429849	0.0425914	7.360490e-01	0.5470351	9.903718e-01	Aldoc	up
69	RAPGEF5	RAPGEF5	0.3193432	0.1604457	1.990350	0.0465524	0.0524216	0.0465524	0.0445547	1.376224e+00	1.0048872	1.884780e+00	Rapgef5	up
43	LDB3	LDB3	0.3834987	0.1921256	1.996083	0.0459248	0.0536589	0.0459248	0.0447002	1.467410e+00	1.0069636	2.138400e+00	Ldb3	up
33	GDF10	GDF10	-0.2476631	0.1253271	-1.976134	0.0481396	0.0394339	0.0481396	0.0457862	7.806229e-01	0.6106083	9.979755e-01	Gdf10	up
84	TPPP	TPPP	0.2895090	0.1455712	1.988779	0.0467256	0.0504267	0.0467256	0.0459345	1.335771e+00	1.0042035	1.776817e+00	Tppp	up
66	PPIL6	PPIL6	-0.8324625	0.4144059	-2.008809	0.0445573	0.0400225	0.0445573	0.0463260	4.349768e-01	0.1930737	9.799617e-01	Ppil6	up
23	CNTNAP4	CNTNAP4	0.4244264	0.2146225	1.977548	0.0479797	0.0526664	0.0479797	0.0466958	1.528713e+00	1.0037811	2.328161e+00	Cntnap4	up
31	FRY	FRY	-0.6944304	0.3511521	-1.977577	0.0479764	0.0486039	0.0479764	0.0472073	4.993588e-01	0.2509062	9.938342e-01	Fry	up
41	IRX2	IRX2	-0.3255989	0.1648842	-1.974713	0.0483007	0.0587783	0.0483007	0.0477633	7.220948e-01	0.5226904	9.975711e-01	Irx2	down
11	CARTPT	CARTPT	0.1630698	0.0843582	1.933065	0.0532282	0.0819939	0.0532282	0.0496218	1.177119e+00	0.9977334	1.388756e+00	Cartpt	up
83	TMCO5A	TMCO5A	82.6409564	43.6960941	1.891266	0.0585888	0.1037047	0.0585888	0.0498658	7.771616e+35	0.0496968	1.215330e+73	Tmco5	up

ONLY IDH

Gene-sets considered

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Table genes

	Variable	Term	Beta	StandardError	Z	P	LRT	Wald	LogRank	HR	HRlower	HRupper	mm	status
36	GPR139	GPR139	5.1595162	1.0707833	4.818450	0.0000014	0.0000396	0.0000014	0.0000000	1.740802e+02	21.3450416	1.419717e+03	Gpr139	up
61	PCDHGA3	PCDHGA3	0.7508024	0.2053482	3.656241	0.0002559	0.0025701	0.0002559	0.0000236	2.118699e+00	1.4166959	3.168560e+00	Pcdhga3	up
18	CHIC2	CHIC2	1.3148603	0.3211465	4.094269	0.0000424	0.0002660	0.0000424	0.0000446	3.724231e+00	1.9846144	6.988710e+00	Chic2	down
63	PHKG1	PHKG1	-0.6406674	0.1684263	-3.803845	0.0001425	0.0002338	0.0001425	0.0001123	5.269406e-01	0.3787887	7.330378e-01	Phkg1	up
3	ADAMTS3	ADAMTS3	3.2224925	1.0514520	3.064802	0.0021781	0.0093278	0.0021781	0.0001595	2.509058e+01	3.1953107	1.970191e+02	Adamts3	up
21	CLEC18A	CLEC18A	2.8000255	0.7790372	3.594213	0.0003254	0.0014044	0.0003254	0.0001713	1.644507e+01	3.5720534	7.571001e+01	Clec18a	up
46	LIX1	LIX1	-0.6899061	0.1972237	-3.498089	0.0004686	0.0005864	0.0004686	0.0003863	5.016232e-01	0.3408007	7.383372e-01	Lix1	up
72	SFTPC	SFTPC	0.7150386	0.2109331	3.389884	0.0006992	0.0007212	0.0006992	0.0005360	2.044266e+00	1.3520438	3.090892e+00	Sftpc	up
62	PCDHGA8	PCDHGA8	5.2362662	1.6538533	3.166101	0.0015450	0.0096278	0.0015450	0.0011135	1.879670e+02	7.3505362	4.806666e+03	Pcdhga8	up
93	ZBTB8B	ZBTB8B	1.1365043	0.3520922	3.227860	0.0012472	0.0015945	0.0012472	0.0011193	3.115857e+00	1.5627018	6.212679e+00	Zbtb8b	up
48	LRRK2	LRRK2	0.5470006	0.1760081	3.107815	0.0018848	0.0038480	0.0018848	0.0016209	1.728062e+00	1.2238861	2.439932e+00	Lrrk2	up
73	SH3GL2	SH3GL2	-0.7681192	0.2405062	-3.193760	0.0014043	0.0017402	0.0014043	0.0017373	4.638847e-01	0.2895282	7.432404e-01	Sh3gl2	up
56	MYH1	MYH1	6.4885350	2.3189710	2.798023	0.0051416	0.0245868	0.0051416	0.0019006	6.575594e+02	6.9826986	6.192224e+04	Myh1	up
10	BVES	BVES	0.6492014	0.2109948	3.076860	0.0020919	0.0034852	0.0020919	0.0022376	1.914012e+00	1.2657428	2.894301e+00	Bves	up
30	FAM186B	FAM186B	3.6808737	1.2262259	3.001791	0.0026840	0.0048851	0.0026840	0.0028607	3.968105e+01	3.5877136	4.388828e+02	Fam186b	up
77	SMIM1	SMIM1	0.8812849	0.3007913	2.929889	0.0033908	0.0049659	0.0033908	0.0032167	2.414000e+00	1.3387614	4.352825e+00	Smim1	up
4	AHCYL2	AHCYL2	-0.6577339	0.2262623	-2.906954	0.0036497	0.0028521	0.0036497	0.0033225	5.180239e-01	0.3324719	8.071320e-01	Ahcyl2	up
35	GLT8D2	GLT8D2	-2.1935510	0.7573641	-2.896297	0.0037760	0.0018451	0.0037760	0.0034438	1.115200e-01	0.0252746	4.920649e-01	Glt8d2	up
16	CEP135	CEP135	0.9612037	0.3279532	2.930917	0.0033796	0.0113210	0.0033796	0.0035540	2.614842e+00	1.3749635	4.972786e+00	Cep135	down
64	PLCXD1	PLCXD1	0.7187168	0.2420552	2.969226	0.0029855	0.0042069	0.0029855	0.0038072	2.051799e+00	1.2767238	3.297407e+00	Plcxd1	up
1	ABCA8	ABCA8	0.4570804	0.1554996	2.939431	0.0032882	0.0086596	0.0032882	0.0038081	1.579456e+00	1.1645174	2.142244e+00	Abca8b	up
38	HHATL	HHATL	0.3972220	0.1379059	2.880384	0.0039719	0.0037733	0.0039719	0.0039397	1.487686e+00	1.1353391	1.949383e+00	Hhatl	up
19	CHRM5	CHRM5	1.9356194	0.6916367	2.798607	0.0051324	0.0113490	0.0051324	0.0039951	6.928334e+00	1.7861035	2.687516e+01	Chrm5	up
8	BARX2	BARX2	4.2196030	1.5075048	2.799064	0.0051251	0.0101462	0.0051251	0.0043039	6.800648e+01	3.5429083	1.305391e+03	Barx2	up
52	METTL11B	METTL11B	2.5058448	0.9684965	2.587356	0.0096716	0.0338070	0.0096716	0.0050058	1.225391e+01	1.8360684	8.178248e+01	Mettl11b	up
13	CCDC87	CCDC87	-0.6405216	0.2300130	-2.784719	0.0053574	0.0053539	0.0053574	0.0051444	5.270174e-01	0.3357666	8.272036e-01	Ccdc87	up
44	LGI3	LGI3	0.3468954	0.1262967	2.746671	0.0060204	0.0058834	0.0060204	0.0056087	1.414669e+00	1.1044621	1.812002e+00	Lgi3	up
90	TUB	TUB	-0.5353015	0.1944482	-2.752925	0.0059065	0.0069206	0.0059065	0.0057163	5.854927e-01	0.3999511	8.571092e-01	Tub	up
74	SLC35F4	SLC35F4	7.7687589	3.3957542	2.287786	0.0221500	0.0864739	0.0221500	0.0063834	2.365534e+03	3.0440926	1.838232e+06	Slc35f4	up
85	TPSAB1	TPSAB1	-0.8846744	0.3542311	-2.497450	0.0125090	0.0006903	0.0125090	0.0063899	4.128486e-01	0.2061905	8.266333e-01	Tpsb2	down
39	HHIP	HHIP	0.5059547	0.1893155	2.672548	0.0075278	0.0125895	0.0075278	0.0067012	1.658568e+00	1.1444259	2.403693e+00	Hhip	up
25	CRTAC1	CRTAC1	-0.5325153	0.2040986	-2.609107	0.0090779	0.0096375	0.0090779	0.0088457	5.871263e-01	0.3935523	8.759123e-01	Crtac1	up
32	FXYD7	FXYD7	0.2876284	0.1121605	2.564436	0.0103343	0.0106282	0.0103343	0.0093643	1.333262e+00	1.0701490	1.661065e+00	Fxyd7	up
6	AOX3P	AOX3P	11.3330802	4.4432645	2.550620	0.0107531	0.0331895	0.0107531	0.0097299	8.353995e+04	13.7968724	5.058337e+08	Aox3	up
76	SLCO4A1	SLCO4A1	0.5349134	0.2092046	2.556891	0.0105612	0.0149816	0.0105612	0.0103656	1.707300e+00	1.1330123	2.572677e+00	Slco4a1	up
91	VWC2	VWC2	-0.8658511	0.3444749	-2.513539	0.0119527	0.0076251	0.0119527	0.0104954	4.206934e-01	0.2141648	8.263865e-01	Vwc2	up
34	GLRA3	GLRA3	-0.7538191	0.3011341	-2.503267	0.0123053	0.0079996	0.0123053	0.0114512	4.705660e-01	0.2607922	8.490756e-01	Glra3	up
75	SLC8A3	SLC8A3	-0.6592973	0.2645167	-2.492460	0.0126862	0.0094084	0.0126862	0.0114866	5.172147e-01	0.3079738	8.686161e-01	Slc8a3	up
65	POPDC3	POPDC3	0.4728442	0.1902276	2.485676	0.0129306	0.0187433	0.0129306	0.0117812	1.604551e+00	1.1051763	2.329569e+00	Popdc3	up
86	TPSB2	TPSB2	-0.8013200	0.3290348	-2.435365	0.0148768	0.0022816	0.0148768	0.0118109	4.487363e-01	0.2354595	8.551968e-01	Tpsb2	down
58	NLRP6	NLRP6	0.6709421	0.2702415	2.482750	0.0130373	0.0218135	0.0130373	0.0125357	1.956079e+00	1.1517453	3.322128e+00	Nlrp6	up
60	PCDH7	PCDH7	-0.6628942	0.2660821	-2.491314	0.0127271	0.0104717	0.0127271	0.0125628	5.153577e-01	0.3059280	8.681569e-01	Pcdh7	up
24	CPA3	CPA3	-3.5762611	1.9488975	-1.835017	0.0665031	0.0007919	0.0665031	0.0136850	2.798010e-02	0.0006137	1.275716e+00	Cpa3	down
15	CDH7	CDH7	-0.8340137	0.3472870	-2.401512	0.0163275	0.0091114	0.0163275	0.0140317	4.343026e-01	0.2198777	8.578348e-01	Cdh7	up
2	ABLIM3	ABLIM3	-0.4808436	0.1974873	-2.434808	0.0148997	0.0152889	0.0148997	0.0144433	6.182616e-01	0.4198275	9.104870e-01	Ablim3	up
9	BMP3	BMP3	1.3553265	0.5709786	2.373690	0.0176113	0.0373274	0.0176113	0.0148387	3.878027e+00	1.2664643	1.187487e+01	Bmp3	up
45	LIPG	LIPG	-0.5180286	0.2142283	-2.418115	0.0156012	0.0156964	0.0156012	0.0151243	5.956937e-01	0.3914458	9.065139e-01	Lipg	up
20	CHST15	CHST15	-0.5033978	0.2093893	-2.404124	0.0162113	0.0171423	0.0162113	0.0158504	6.044733e-01	0.4010002	9.111914e-01	Chst15	up
50	MAP6D1	MAP6D1	0.3774339	0.1582533	2.384999	0.0170792	0.0189951	0.0170792	0.0161717	1.458537e+00	1.0695770	1.988946e+00	Map6d1	up
67	PPP2R2B	PPP2R2B	-0.8738006	0.3636238	-2.403035	0.0162596	0.0143470	0.0162596	0.0162598	4.173623e-01	0.2046426	8.511975e-01	Ppp2r2b	up
53	MGAT4C	MGAT4C	-1.3967395	0.5768181	-2.421456	0.0154585	0.0077684	0.0154585	0.0173673	2.474023e-01	0.0798758	7.662883e-01	Mgat4c	up
49	LUZP2	LUZP2	-0.5286152	0.2259100	-2.339937	0.0192870	0.0215066	0.0192870	0.0185859	5.894206e-01	0.3785562	9.177414e-01	Luzp2	up
22	CLMN	CLMN	0.6592381	0.2808949	2.346921	0.0189293	0.0300935	0.0189293	0.0196584	1.933319e+00	1.1148214	3.352753e+00	Clmn	up
79	SPOCK3	SPOCK3	0.5432691	0.2349925	2.311857	0.0207855	0.0283806	0.0207855	0.0197538	1.721626e+00	1.0862075	2.728756e+00	Spock3	up
70	RNF32	RNF32	-0.8573740	0.3707326	-2.312648	0.0207420	0.0208589	0.0207420	0.0203103	4.242748e-01	0.2051536	8.774358e-01	Rnf32	up
59	NSUN7	NSUN7	3.4739776	1.5269652	2.275086	0.0229008	0.0292430	0.0229008	0.0214978	3.226482e+01	1.6179837	6.434050e+02	Nsun7	up
89	TTLL7	TTLL7	0.5323731	0.2360615	2.255231	0.0241189	0.0273676	0.0241189	0.0242335	1.702969e+00	1.0721876	2.704847e+00	Ttll7	up
7	ARHGAP8	ARHGAP8	20.8761762	9.4024620	2.220288	0.0263992	0.0399771	0.0263992	0.0246239	1.165220e+09	11.5616004	1.174352e+17	Arhgap8	down
82	TGM3	TGM3	-4.2363329	1.9422468	-2.181151	0.0291723	0.0073239	0.0291723	0.0251856	1.446050e-02	0.0003213	6.507699e-01	Tgm3	up
71	SERINC2	SERINC2	0.4735774	0.2137832	2.215223	0.0267448	0.0318912	0.0267448	0.0261266	1.605728e+00	1.0560865	2.441432e+00	Serinc2	up
55	MUSK	MUSK	14.1949811	6.5867212	2.155091	0.0311547	0.0678555	0.0311547	0.0279285	1.461511e+06	3.6155532	5.907847e+11	Musk	up
12	CCDC74B	CCDC74B	-0.5455931	0.2493796	-2.187802	0.0286840	0.0294507	0.0286840	0.0283321	5.794980e-01	0.3554509	9.447659e-01	Ccdc74a	up
42	KCNG1	KCNG1	-0.4093191	0.1876366	-2.181446	0.0291504	0.0208728	0.0291504	0.0291734	6.641023e-01	0.4597465	9.592936e-01	Kcng1	up
28	FAM110B	FAM110B	-0.4469752	0.2066142	-2.163333	0.0305156	0.0322178	0.0305156	0.0297200	6.395597e-01	0.4265901	9.588517e-01	Fam110b	up
68	PRSS35	PRSS35	-0.2598632	0.1208744	-2.149861	0.0315662	0.0362531	0.0315662	0.0299232	7.711571e-01	0.6084913	9.773077e-01	Prss35	up
27	EFCAB6	EFCAB6	-4.6697434	2.1733079	-2.148680	0.0316598	0.0230073	0.0316598	0.0302239	9.374700e-03	0.0001324	6.635586e-01	Efcab6	up
40	INHBA	INHBA	-0.7294275	0.3291556	-2.216057	0.0266876	0.0184006	0.0266876	0.0302935	4.821850e-01	0.2529507	9.191606e-01	Inhba	up
80	SYT17	SYT17	-0.7200108	0.3371428	-2.135626	0.0327099	0.0303318	0.0327099	0.0319226	4.867470e-01	0.2513778	9.424965e-01	Syt17	up
26	CRYBB1	CRYBB1	-0.6315141	0.2924614	-2.159307	0.0308263	0.0275145	0.0308263	0.0323952	5.317860e-01	0.2997735	9.433667e-01	Crybb1	up
51	MEIG1	MEIG1	-1.5568552	0.7345368	-2.119506	0.0340477	0.0203682	0.0340477	0.0328155	2.107979e-01	0.0499606	8.894166e-01	Meig1	up
87	TRPC1	TRPC1	-0.9133696	0.4337654	-2.105676	0.0352325	0.0361240	0.0352325	0.0336084	4.011702e-01	0.1714379	9.387510e-01	Trpc1	up
88	TTLL11	TTLL11	1.6033388	0.7533240	2.128352	0.0333079	0.0457185	0.0333079	0.0338183	4.969597e+00	1.1352478	2.175463e+01	Ttll11	up
37	GRIA3	GRIA3	-0.5537059	0.2629723	-2.105567	0.0352420	0.0362229	0.0352420	0.0339876	5.748157e-01	0.3433098	9.624341e-01	Gria3	up
78	SPHKAP	SPHKAP	-0.3948747	0.1885112	-2.094701	0.0361976	0.0354954	0.0361976	0.0350410	6.737645e-01	0.4656365	9.749204e-01	Sphkap	up
17	CES1	CES1	-1.2365117	0.6037801	-2.047950	0.0405649	0.0117912	0.0405649	0.0353114	2.903954e-01	0.0889306	9.482620e-01	Ces1d	up
92	WNT4	WNT4	-0.8323685	0.4111895	-2.024294	0.0429399	0.0156938	0.0429399	0.0364697	4.350177e-01	0.1943130	9.738950e-01	Wnt4	up
29	FAM135B	FAM135B	-1.1288911	0.5417063	-2.083954	0.0371643	0.0296138	0.0371643	0.0366978	3.233917e-01	0.1118478	9.350398e-01	Fam135b	up
57	NIPAL3	NIPAL3	0.3346470	0.1612557	2.075257	0.0379627	0.0390300	0.0379627	0.0369967	1.397447e+00	1.0187656	1.916887e+00	Nipal3	up
14	CCL27	CCL27	-8.0296337	4.5567387	-1.762145	0.0780448	0.0069579	0.0780448	0.0373252	3.257000e-04	0.0000000	2.463074e+00	Ccl27a	up
54	MT3	MT3	0.3041427	0.1425664	2.133341	0.0328967	0.0234258	0.0328967	0.0395999	1.355462e+00	1.0250258	1.792422e+00	Mt3	up
47	LRRC6	LRRC6	-1.0838316	0.5327818	-2.034288	0.0419226	0.0388757	0.0419226	0.0396194	3.382968e-01	0.1190675	9.611754e-01	Lrrc6	up
81	TENM4	TENM4	-0.6701993	0.3295016	-2.033979	0.0419538	0.0392560	0.0419538	0.0413113	5.116066e-01	0.2682031	9.759070e-01	Tenm4	up
5	ALDOC	ALDOC	-0.3064586	0.1514231	-2.023857	0.0429849	0.0525149	0.0429849	0.0425914	7.360490e-01	0.5470351	9.903718e-01	Aldoc	up
69	RAPGEF5	RAPGEF5	0.3193432	0.1604457	1.990350	0.0465524	0.0524216	0.0465524	0.0445547	1.376224e+00	1.0048872	1.884780e+00	Rapgef5	up
43	LDB3	LDB3	0.3834987	0.1921256	1.996083	0.0459248	0.0536589	0.0459248	0.0447002	1.467410e+00	1.0069636	2.138400e+00	Ldb3	up
33	GDF10	GDF10	-0.2476631	0.1253271	-1.976134	0.0481396	0.0394339	0.0481396	0.0457862	7.806229e-01	0.6106083	9.979755e-01	Gdf10	up
84	TPPP	TPPP	0.2895090	0.1455712	1.988779	0.0467256	0.0504267	0.0467256	0.0459345	1.335771e+00	1.0042035	1.776817e+00	Tppp	up
66	PPIL6	PPIL6	-0.8324625	0.4144059	-2.008809	0.0445573	0.0400225	0.0445573	0.0463260	4.349768e-01	0.1930737	9.799617e-01	Ppil6	up
23	CNTNAP4	CNTNAP4	0.4244264	0.2146225	1.977548	0.0479797	0.0526664	0.0479797	0.0466958	1.528713e+00	1.0037811	2.328161e+00	Cntnap4	up
31	FRY	FRY	-0.6944304	0.3511521	-1.977577	0.0479764	0.0486039	0.0479764	0.0472073	4.993588e-01	0.2509062	9.938342e-01	Fry	up
41	IRX2	IRX2	-0.3255989	0.1648842	-1.974713	0.0483007	0.0587783	0.0483007	0.0477633	7.220948e-01	0.5226904	9.975711e-01	Irx2	down
11	CARTPT	CARTPT	0.1630698	0.0843582	1.933065	0.0532282	0.0819939	0.0532282	0.0496218	1.177119e+00	0.9977334	1.388756e+00	Cartpt	up
83	TMCO5A	TMCO5A	82.6409564	43.6960941	1.891266	0.0585888	0.1037047	0.0585888	0.0498658	7.771616e+35	0.0496968	1.215330e+73	Tmco5	up

IDH_CODEL_NOCODEL

Gene-sets considered

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Table genes

	Variable	Term	Beta	StandardError	Z	P	LRT	Wald	LogRank	HR	HRlower	HRupper	mm	status
36	GPR139	GPR139	5.1595162	1.0707833	4.818450	0.0000014	0.0000396	0.0000014	0.0000000	1.740802e+02	21.3450416	1.419717e+03	Gpr139	up
61	PCDHGA3	PCDHGA3	0.7508024	0.2053482	3.656241	0.0002559	0.0025701	0.0002559	0.0000236	2.118699e+00	1.4166959	3.168560e+00	Pcdhga3	up
18	CHIC2	CHIC2	1.3148603	0.3211465	4.094269	0.0000424	0.0002660	0.0000424	0.0000446	3.724231e+00	1.9846144	6.988710e+00	Chic2	down
63	PHKG1	PHKG1	-0.6406674	0.1684263	-3.803845	0.0001425	0.0002338	0.0001425	0.0001123	5.269406e-01	0.3787887	7.330378e-01	Phkg1	up
3	ADAMTS3	ADAMTS3	3.2224925	1.0514520	3.064802	0.0021781	0.0093278	0.0021781	0.0001595	2.509058e+01	3.1953107	1.970191e+02	Adamts3	up
21	CLEC18A	CLEC18A	2.8000255	0.7790372	3.594213	0.0003254	0.0014044	0.0003254	0.0001713	1.644507e+01	3.5720534	7.571001e+01	Clec18a	up
46	LIX1	LIX1	-0.6899061	0.1972237	-3.498089	0.0004686	0.0005864	0.0004686	0.0003863	5.016232e-01	0.3408007	7.383372e-01	Lix1	up
72	SFTPC	SFTPC	0.7150386	0.2109331	3.389884	0.0006992	0.0007212	0.0006992	0.0005360	2.044266e+00	1.3520438	3.090892e+00	Sftpc	up
62	PCDHGA8	PCDHGA8	5.2362662	1.6538533	3.166101	0.0015450	0.0096278	0.0015450	0.0011135	1.879670e+02	7.3505362	4.806666e+03	Pcdhga8	up
93	ZBTB8B	ZBTB8B	1.1365043	0.3520922	3.227860	0.0012472	0.0015945	0.0012472	0.0011193	3.115857e+00	1.5627018	6.212679e+00	Zbtb8b	up
48	LRRK2	LRRK2	0.5470006	0.1760081	3.107815	0.0018848	0.0038480	0.0018848	0.0016209	1.728062e+00	1.2238861	2.439932e+00	Lrrk2	up
73	SH3GL2	SH3GL2	-0.7681192	0.2405062	-3.193760	0.0014043	0.0017402	0.0014043	0.0017373	4.638847e-01	0.2895282	7.432404e-01	Sh3gl2	up
56	MYH1	MYH1	6.4885350	2.3189710	2.798023	0.0051416	0.0245868	0.0051416	0.0019006	6.575594e+02	6.9826986	6.192224e+04	Myh1	up
10	BVES	BVES	0.6492014	0.2109948	3.076860	0.0020919	0.0034852	0.0020919	0.0022376	1.914012e+00	1.2657428	2.894301e+00	Bves	up
30	FAM186B	FAM186B	3.6808737	1.2262259	3.001791	0.0026840	0.0048851	0.0026840	0.0028607	3.968105e+01	3.5877136	4.388828e+02	Fam186b	up
77	SMIM1	SMIM1	0.8812849	0.3007913	2.929889	0.0033908	0.0049659	0.0033908	0.0032167	2.414000e+00	1.3387614	4.352825e+00	Smim1	up
4	AHCYL2	AHCYL2	-0.6577339	0.2262623	-2.906954	0.0036497	0.0028521	0.0036497	0.0033225	5.180239e-01	0.3324719	8.071320e-01	Ahcyl2	up
35	GLT8D2	GLT8D2	-2.1935510	0.7573641	-2.896297	0.0037760	0.0018451	0.0037760	0.0034438	1.115200e-01	0.0252746	4.920649e-01	Glt8d2	up
16	CEP135	CEP135	0.9612037	0.3279532	2.930917	0.0033796	0.0113210	0.0033796	0.0035540	2.614842e+00	1.3749635	4.972786e+00	Cep135	down
64	PLCXD1	PLCXD1	0.7187168	0.2420552	2.969226	0.0029855	0.0042069	0.0029855	0.0038072	2.051799e+00	1.2767238	3.297407e+00	Plcxd1	up
1	ABCA8	ABCA8	0.4570804	0.1554996	2.939431	0.0032882	0.0086596	0.0032882	0.0038081	1.579456e+00	1.1645174	2.142244e+00	Abca8b	up
38	HHATL	HHATL	0.3972220	0.1379059	2.880384	0.0039719	0.0037733	0.0039719	0.0039397	1.487686e+00	1.1353391	1.949383e+00	Hhatl	up
19	CHRM5	CHRM5	1.9356194	0.6916367	2.798607	0.0051324	0.0113490	0.0051324	0.0039951	6.928334e+00	1.7861035	2.687516e+01	Chrm5	up
8	BARX2	BARX2	4.2196030	1.5075048	2.799064	0.0051251	0.0101462	0.0051251	0.0043039	6.800648e+01	3.5429083	1.305391e+03	Barx2	up
52	METTL11B	METTL11B	2.5058448	0.9684965	2.587356	0.0096716	0.0338070	0.0096716	0.0050058	1.225391e+01	1.8360684	8.178248e+01	Mettl11b	up
13	CCDC87	CCDC87	-0.6405216	0.2300130	-2.784719	0.0053574	0.0053539	0.0053574	0.0051444	5.270174e-01	0.3357666	8.272036e-01	Ccdc87	up
44	LGI3	LGI3	0.3468954	0.1262967	2.746671	0.0060204	0.0058834	0.0060204	0.0056087	1.414669e+00	1.1044621	1.812002e+00	Lgi3	up
90	TUB	TUB	-0.5353015	0.1944482	-2.752925	0.0059065	0.0069206	0.0059065	0.0057163	5.854927e-01	0.3999511	8.571092e-01	Tub	up
74	SLC35F4	SLC35F4	7.7687589	3.3957542	2.287786	0.0221500	0.0864739	0.0221500	0.0063834	2.365534e+03	3.0440926	1.838232e+06	Slc35f4	up
85	TPSAB1	TPSAB1	-0.8846744	0.3542311	-2.497450	0.0125090	0.0006903	0.0125090	0.0063899	4.128486e-01	0.2061905	8.266333e-01	Tpsb2	down
39	HHIP	HHIP	0.5059547	0.1893155	2.672548	0.0075278	0.0125895	0.0075278	0.0067012	1.658568e+00	1.1444259	2.403693e+00	Hhip	up
25	CRTAC1	CRTAC1	-0.5325153	0.2040986	-2.609107	0.0090779	0.0096375	0.0090779	0.0088457	5.871263e-01	0.3935523	8.759123e-01	Crtac1	up
32	FXYD7	FXYD7	0.2876284	0.1121605	2.564436	0.0103343	0.0106282	0.0103343	0.0093643	1.333262e+00	1.0701490	1.661065e+00	Fxyd7	up
6	AOX3P	AOX3P	11.3330802	4.4432645	2.550620	0.0107531	0.0331895	0.0107531	0.0097299	8.353995e+04	13.7968724	5.058337e+08	Aox3	up
76	SLCO4A1	SLCO4A1	0.5349134	0.2092046	2.556891	0.0105612	0.0149816	0.0105612	0.0103656	1.707300e+00	1.1330123	2.572677e+00	Slco4a1	up
91	VWC2	VWC2	-0.8658511	0.3444749	-2.513539	0.0119527	0.0076251	0.0119527	0.0104954	4.206934e-01	0.2141648	8.263865e-01	Vwc2	up
34	GLRA3	GLRA3	-0.7538191	0.3011341	-2.503267	0.0123053	0.0079996	0.0123053	0.0114512	4.705660e-01	0.2607922	8.490756e-01	Glra3	up
75	SLC8A3	SLC8A3	-0.6592973	0.2645167	-2.492460	0.0126862	0.0094084	0.0126862	0.0114866	5.172147e-01	0.3079738	8.686161e-01	Slc8a3	up
65	POPDC3	POPDC3	0.4728442	0.1902276	2.485676	0.0129306	0.0187433	0.0129306	0.0117812	1.604551e+00	1.1051763	2.329569e+00	Popdc3	up
86	TPSB2	TPSB2	-0.8013200	0.3290348	-2.435365	0.0148768	0.0022816	0.0148768	0.0118109	4.487363e-01	0.2354595	8.551968e-01	Tpsb2	down
58	NLRP6	NLRP6	0.6709421	0.2702415	2.482750	0.0130373	0.0218135	0.0130373	0.0125357	1.956079e+00	1.1517453	3.322128e+00	Nlrp6	up
60	PCDH7	PCDH7	-0.6628942	0.2660821	-2.491314	0.0127271	0.0104717	0.0127271	0.0125628	5.153577e-01	0.3059280	8.681569e-01	Pcdh7	up
24	CPA3	CPA3	-3.5762611	1.9488975	-1.835017	0.0665031	0.0007919	0.0665031	0.0136850	2.798010e-02	0.0006137	1.275716e+00	Cpa3	down
15	CDH7	CDH7	-0.8340137	0.3472870	-2.401512	0.0163275	0.0091114	0.0163275	0.0140317	4.343026e-01	0.2198777	8.578348e-01	Cdh7	up
2	ABLIM3	ABLIM3	-0.4808436	0.1974873	-2.434808	0.0148997	0.0152889	0.0148997	0.0144433	6.182616e-01	0.4198275	9.104870e-01	Ablim3	up
9	BMP3	BMP3	1.3553265	0.5709786	2.373690	0.0176113	0.0373274	0.0176113	0.0148387	3.878027e+00	1.2664643	1.187487e+01	Bmp3	up
45	LIPG	LIPG	-0.5180286	0.2142283	-2.418115	0.0156012	0.0156964	0.0156012	0.0151243	5.956937e-01	0.3914458	9.065139e-01	Lipg	up
20	CHST15	CHST15	-0.5033978	0.2093893	-2.404124	0.0162113	0.0171423	0.0162113	0.0158504	6.044733e-01	0.4010002	9.111914e-01	Chst15	up
50	MAP6D1	MAP6D1	0.3774339	0.1582533	2.384999	0.0170792	0.0189951	0.0170792	0.0161717	1.458537e+00	1.0695770	1.988946e+00	Map6d1	up
67	PPP2R2B	PPP2R2B	-0.8738006	0.3636238	-2.403035	0.0162596	0.0143470	0.0162596	0.0162598	4.173623e-01	0.2046426	8.511975e-01	Ppp2r2b	up
53	MGAT4C	MGAT4C	-1.3967395	0.5768181	-2.421456	0.0154585	0.0077684	0.0154585	0.0173673	2.474023e-01	0.0798758	7.662883e-01	Mgat4c	up
49	LUZP2	LUZP2	-0.5286152	0.2259100	-2.339937	0.0192870	0.0215066	0.0192870	0.0185859	5.894206e-01	0.3785562	9.177414e-01	Luzp2	up
22	CLMN	CLMN	0.6592381	0.2808949	2.346921	0.0189293	0.0300935	0.0189293	0.0196584	1.933319e+00	1.1148214	3.352753e+00	Clmn	up
79	SPOCK3	SPOCK3	0.5432691	0.2349925	2.311857	0.0207855	0.0283806	0.0207855	0.0197538	1.721626e+00	1.0862075	2.728756e+00	Spock3	up
70	RNF32	RNF32	-0.8573740	0.3707326	-2.312648	0.0207420	0.0208589	0.0207420	0.0203103	4.242748e-01	0.2051536	8.774358e-01	Rnf32	up
59	NSUN7	NSUN7	3.4739776	1.5269652	2.275086	0.0229008	0.0292430	0.0229008	0.0214978	3.226482e+01	1.6179837	6.434050e+02	Nsun7	up
89	TTLL7	TTLL7	0.5323731	0.2360615	2.255231	0.0241189	0.0273676	0.0241189	0.0242335	1.702969e+00	1.0721876	2.704847e+00	Ttll7	up
7	ARHGAP8	ARHGAP8	20.8761762	9.4024620	2.220288	0.0263992	0.0399771	0.0263992	0.0246239	1.165220e+09	11.5616004	1.174352e+17	Arhgap8	down
82	TGM3	TGM3	-4.2363329	1.9422468	-2.181151	0.0291723	0.0073239	0.0291723	0.0251856	1.446050e-02	0.0003213	6.507699e-01	Tgm3	up
71	SERINC2	SERINC2	0.4735774	0.2137832	2.215223	0.0267448	0.0318912	0.0267448	0.0261266	1.605728e+00	1.0560865	2.441432e+00	Serinc2	up
55	MUSK	MUSK	14.1949811	6.5867212	2.155091	0.0311547	0.0678555	0.0311547	0.0279285	1.461511e+06	3.6155532	5.907847e+11	Musk	up
12	CCDC74B	CCDC74B	-0.5455931	0.2493796	-2.187802	0.0286840	0.0294507	0.0286840	0.0283321	5.794980e-01	0.3554509	9.447659e-01	Ccdc74a	up
42	KCNG1	KCNG1	-0.4093191	0.1876366	-2.181446	0.0291504	0.0208728	0.0291504	0.0291734	6.641023e-01	0.4597465	9.592936e-01	Kcng1	up
28	FAM110B	FAM110B	-0.4469752	0.2066142	-2.163333	0.0305156	0.0322178	0.0305156	0.0297200	6.395597e-01	0.4265901	9.588517e-01	Fam110b	up
68	PRSS35	PRSS35	-0.2598632	0.1208744	-2.149861	0.0315662	0.0362531	0.0315662	0.0299232	7.711571e-01	0.6084913	9.773077e-01	Prss35	up
27	EFCAB6	EFCAB6	-4.6697434	2.1733079	-2.148680	0.0316598	0.0230073	0.0316598	0.0302239	9.374700e-03	0.0001324	6.635586e-01	Efcab6	up
40	INHBA	INHBA	-0.7294275	0.3291556	-2.216057	0.0266876	0.0184006	0.0266876	0.0302935	4.821850e-01	0.2529507	9.191606e-01	Inhba	up
80	SYT17	SYT17	-0.7200108	0.3371428	-2.135626	0.0327099	0.0303318	0.0327099	0.0319226	4.867470e-01	0.2513778	9.424965e-01	Syt17	up
26	CRYBB1	CRYBB1	-0.6315141	0.2924614	-2.159307	0.0308263	0.0275145	0.0308263	0.0323952	5.317860e-01	0.2997735	9.433667e-01	Crybb1	up
51	MEIG1	MEIG1	-1.5568552	0.7345368	-2.119506	0.0340477	0.0203682	0.0340477	0.0328155	2.107979e-01	0.0499606	8.894166e-01	Meig1	up
87	TRPC1	TRPC1	-0.9133696	0.4337654	-2.105676	0.0352325	0.0361240	0.0352325	0.0336084	4.011702e-01	0.1714379	9.387510e-01	Trpc1	up
88	TTLL11	TTLL11	1.6033388	0.7533240	2.128352	0.0333079	0.0457185	0.0333079	0.0338183	4.969597e+00	1.1352478	2.175463e+01	Ttll11	up
37	GRIA3	GRIA3	-0.5537059	0.2629723	-2.105567	0.0352420	0.0362229	0.0352420	0.0339876	5.748157e-01	0.3433098	9.624341e-01	Gria3	up
78	SPHKAP	SPHKAP	-0.3948747	0.1885112	-2.094701	0.0361976	0.0354954	0.0361976	0.0350410	6.737645e-01	0.4656365	9.749204e-01	Sphkap	up
17	CES1	CES1	-1.2365117	0.6037801	-2.047950	0.0405649	0.0117912	0.0405649	0.0353114	2.903954e-01	0.0889306	9.482620e-01	Ces1d	up
92	WNT4	WNT4	-0.8323685	0.4111895	-2.024294	0.0429399	0.0156938	0.0429399	0.0364697	4.350177e-01	0.1943130	9.738950e-01	Wnt4	up
29	FAM135B	FAM135B	-1.1288911	0.5417063	-2.083954	0.0371643	0.0296138	0.0371643	0.0366978	3.233917e-01	0.1118478	9.350398e-01	Fam135b	up
57	NIPAL3	NIPAL3	0.3346470	0.1612557	2.075257	0.0379627	0.0390300	0.0379627	0.0369967	1.397447e+00	1.0187656	1.916887e+00	Nipal3	up
14	CCL27	CCL27	-8.0296337	4.5567387	-1.762145	0.0780448	0.0069579	0.0780448	0.0373252	3.257000e-04	0.0000000	2.463074e+00	Ccl27a	up
54	MT3	MT3	0.3041427	0.1425664	2.133341	0.0328967	0.0234258	0.0328967	0.0395999	1.355462e+00	1.0250258	1.792422e+00	Mt3	up
47	LRRC6	LRRC6	-1.0838316	0.5327818	-2.034288	0.0419226	0.0388757	0.0419226	0.0396194	3.382968e-01	0.1190675	9.611754e-01	Lrrc6	up
81	TENM4	TENM4	-0.6701993	0.3295016	-2.033979	0.0419538	0.0392560	0.0419538	0.0413113	5.116066e-01	0.2682031	9.759070e-01	Tenm4	up
5	ALDOC	ALDOC	-0.3064586	0.1514231	-2.023857	0.0429849	0.0525149	0.0429849	0.0425914	7.360490e-01	0.5470351	9.903718e-01	Aldoc	up
69	RAPGEF5	RAPGEF5	0.3193432	0.1604457	1.990350	0.0465524	0.0524216	0.0465524	0.0445547	1.376224e+00	1.0048872	1.884780e+00	Rapgef5	up
43	LDB3	LDB3	0.3834987	0.1921256	1.996083	0.0459248	0.0536589	0.0459248	0.0447002	1.467410e+00	1.0069636	2.138400e+00	Ldb3	up
33	GDF10	GDF10	-0.2476631	0.1253271	-1.976134	0.0481396	0.0394339	0.0481396	0.0457862	7.806229e-01	0.6106083	9.979755e-01	Gdf10	up
84	TPPP	TPPP	0.2895090	0.1455712	1.988779	0.0467256	0.0504267	0.0467256	0.0459345	1.335771e+00	1.0042035	1.776817e+00	Tppp	up
66	PPIL6	PPIL6	-0.8324625	0.4144059	-2.008809	0.0445573	0.0400225	0.0445573	0.0463260	4.349768e-01	0.1930737	9.799617e-01	Ppil6	up
23	CNTNAP4	CNTNAP4	0.4244264	0.2146225	1.977548	0.0479797	0.0526664	0.0479797	0.0466958	1.528713e+00	1.0037811	2.328161e+00	Cntnap4	up
31	FRY	FRY	-0.6944304	0.3511521	-1.977577	0.0479764	0.0486039	0.0479764	0.0472073	4.993588e-01	0.2509062	9.938342e-01	Fry	up
41	IRX2	IRX2	-0.3255989	0.1648842	-1.974713	0.0483007	0.0587783	0.0483007	0.0477633	7.220948e-01	0.5226904	9.975711e-01	Irx2	down
11	CARTPT	CARTPT	0.1630698	0.0843582	1.933065	0.0532282	0.0819939	0.0532282	0.0496218	1.177119e+00	0.9977334	1.388756e+00	Cartpt	up
83	TMCO5A	TMCO5A	82.6409564	43.6960941	1.891266	0.0585888	0.1037047	0.0585888	0.0498658	7.771616e+35	0.0496968	1.215330e+73	Tmco5	up

IDH_CODEL

Gene-sets considered

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Table genes

	Variable	Term	Beta	StandardError	Z	P	LRT	Wald	LogRank	HR	HRlower	HRupper	mm	status
36	GPR139	GPR139	5.1595162	1.0707833	4.818450	0.0000014	0.0000396	0.0000014	0.0000000	1.740802e+02	21.3450416	1.419717e+03	Gpr139	up
61	PCDHGA3	PCDHGA3	0.7508024	0.2053482	3.656241	0.0002559	0.0025701	0.0002559	0.0000236	2.118699e+00	1.4166959	3.168560e+00	Pcdhga3	up
18	CHIC2	CHIC2	1.3148603	0.3211465	4.094269	0.0000424	0.0002660	0.0000424	0.0000446	3.724231e+00	1.9846144	6.988710e+00	Chic2	down
63	PHKG1	PHKG1	-0.6406674	0.1684263	-3.803845	0.0001425	0.0002338	0.0001425	0.0001123	5.269406e-01	0.3787887	7.330378e-01	Phkg1	up
3	ADAMTS3	ADAMTS3	3.2224925	1.0514520	3.064802	0.0021781	0.0093278	0.0021781	0.0001595	2.509058e+01	3.1953107	1.970191e+02	Adamts3	up
21	CLEC18A	CLEC18A	2.8000255	0.7790372	3.594213	0.0003254	0.0014044	0.0003254	0.0001713	1.644507e+01	3.5720534	7.571001e+01	Clec18a	up
46	LIX1	LIX1	-0.6899061	0.1972237	-3.498089	0.0004686	0.0005864	0.0004686	0.0003863	5.016232e-01	0.3408007	7.383372e-01	Lix1	up
72	SFTPC	SFTPC	0.7150386	0.2109331	3.389884	0.0006992	0.0007212	0.0006992	0.0005360	2.044266e+00	1.3520438	3.090892e+00	Sftpc	up
62	PCDHGA8	PCDHGA8	5.2362662	1.6538533	3.166101	0.0015450	0.0096278	0.0015450	0.0011135	1.879670e+02	7.3505362	4.806666e+03	Pcdhga8	up
93	ZBTB8B	ZBTB8B	1.1365043	0.3520922	3.227860	0.0012472	0.0015945	0.0012472	0.0011193	3.115857e+00	1.5627018	6.212679e+00	Zbtb8b	up
48	LRRK2	LRRK2	0.5470006	0.1760081	3.107815	0.0018848	0.0038480	0.0018848	0.0016209	1.728062e+00	1.2238861	2.439932e+00	Lrrk2	up
73	SH3GL2	SH3GL2	-0.7681192	0.2405062	-3.193760	0.0014043	0.0017402	0.0014043	0.0017373	4.638847e-01	0.2895282	7.432404e-01	Sh3gl2	up
56	MYH1	MYH1	6.4885350	2.3189710	2.798023	0.0051416	0.0245868	0.0051416	0.0019006	6.575594e+02	6.9826986	6.192224e+04	Myh1	up
10	BVES	BVES	0.6492014	0.2109948	3.076860	0.0020919	0.0034852	0.0020919	0.0022376	1.914012e+00	1.2657428	2.894301e+00	Bves	up
30	FAM186B	FAM186B	3.6808737	1.2262259	3.001791	0.0026840	0.0048851	0.0026840	0.0028607	3.968105e+01	3.5877136	4.388828e+02	Fam186b	up
77	SMIM1	SMIM1	0.8812849	0.3007913	2.929889	0.0033908	0.0049659	0.0033908	0.0032167	2.414000e+00	1.3387614	4.352825e+00	Smim1	up
4	AHCYL2	AHCYL2	-0.6577339	0.2262623	-2.906954	0.0036497	0.0028521	0.0036497	0.0033225	5.180239e-01	0.3324719	8.071320e-01	Ahcyl2	up
35	GLT8D2	GLT8D2	-2.1935510	0.7573641	-2.896297	0.0037760	0.0018451	0.0037760	0.0034438	1.115200e-01	0.0252746	4.920649e-01	Glt8d2	up
16	CEP135	CEP135	0.9612037	0.3279532	2.930917	0.0033796	0.0113210	0.0033796	0.0035540	2.614842e+00	1.3749635	4.972786e+00	Cep135	down
64	PLCXD1	PLCXD1	0.7187168	0.2420552	2.969226	0.0029855	0.0042069	0.0029855	0.0038072	2.051799e+00	1.2767238	3.297407e+00	Plcxd1	up
1	ABCA8	ABCA8	0.4570804	0.1554996	2.939431	0.0032882	0.0086596	0.0032882	0.0038081	1.579456e+00	1.1645174	2.142244e+00	Abca8b	up
38	HHATL	HHATL	0.3972220	0.1379059	2.880384	0.0039719	0.0037733	0.0039719	0.0039397	1.487686e+00	1.1353391	1.949383e+00	Hhatl	up
19	CHRM5	CHRM5	1.9356194	0.6916367	2.798607	0.0051324	0.0113490	0.0051324	0.0039951	6.928334e+00	1.7861035	2.687516e+01	Chrm5	up
8	BARX2	BARX2	4.2196030	1.5075048	2.799064	0.0051251	0.0101462	0.0051251	0.0043039	6.800648e+01	3.5429083	1.305391e+03	Barx2	up
52	METTL11B	METTL11B	2.5058448	0.9684965	2.587356	0.0096716	0.0338070	0.0096716	0.0050058	1.225391e+01	1.8360684	8.178248e+01	Mettl11b	up
13	CCDC87	CCDC87	-0.6405216	0.2300130	-2.784719	0.0053574	0.0053539	0.0053574	0.0051444	5.270174e-01	0.3357666	8.272036e-01	Ccdc87	up
44	LGI3	LGI3	0.3468954	0.1262967	2.746671	0.0060204	0.0058834	0.0060204	0.0056087	1.414669e+00	1.1044621	1.812002e+00	Lgi3	up
90	TUB	TUB	-0.5353015	0.1944482	-2.752925	0.0059065	0.0069206	0.0059065	0.0057163	5.854927e-01	0.3999511	8.571092e-01	Tub	up
74	SLC35F4	SLC35F4	7.7687589	3.3957542	2.287786	0.0221500	0.0864739	0.0221500	0.0063834	2.365534e+03	3.0440926	1.838232e+06	Slc35f4	up
85	TPSAB1	TPSAB1	-0.8846744	0.3542311	-2.497450	0.0125090	0.0006903	0.0125090	0.0063899	4.128486e-01	0.2061905	8.266333e-01	Tpsb2	down
39	HHIP	HHIP	0.5059547	0.1893155	2.672548	0.0075278	0.0125895	0.0075278	0.0067012	1.658568e+00	1.1444259	2.403693e+00	Hhip	up
25	CRTAC1	CRTAC1	-0.5325153	0.2040986	-2.609107	0.0090779	0.0096375	0.0090779	0.0088457	5.871263e-01	0.3935523	8.759123e-01	Crtac1	up
32	FXYD7	FXYD7	0.2876284	0.1121605	2.564436	0.0103343	0.0106282	0.0103343	0.0093643	1.333262e+00	1.0701490	1.661065e+00	Fxyd7	up
6	AOX3P	AOX3P	11.3330802	4.4432645	2.550620	0.0107531	0.0331895	0.0107531	0.0097299	8.353995e+04	13.7968724	5.058337e+08	Aox3	up
76	SLCO4A1	SLCO4A1	0.5349134	0.2092046	2.556891	0.0105612	0.0149816	0.0105612	0.0103656	1.707300e+00	1.1330123	2.572677e+00	Slco4a1	up
91	VWC2	VWC2	-0.8658511	0.3444749	-2.513539	0.0119527	0.0076251	0.0119527	0.0104954	4.206934e-01	0.2141648	8.263865e-01	Vwc2	up
34	GLRA3	GLRA3	-0.7538191	0.3011341	-2.503267	0.0123053	0.0079996	0.0123053	0.0114512	4.705660e-01	0.2607922	8.490756e-01	Glra3	up
75	SLC8A3	SLC8A3	-0.6592973	0.2645167	-2.492460	0.0126862	0.0094084	0.0126862	0.0114866	5.172147e-01	0.3079738	8.686161e-01	Slc8a3	up
65	POPDC3	POPDC3	0.4728442	0.1902276	2.485676	0.0129306	0.0187433	0.0129306	0.0117812	1.604551e+00	1.1051763	2.329569e+00	Popdc3	up
86	TPSB2	TPSB2	-0.8013200	0.3290348	-2.435365	0.0148768	0.0022816	0.0148768	0.0118109	4.487363e-01	0.2354595	8.551968e-01	Tpsb2	down
58	NLRP6	NLRP6	0.6709421	0.2702415	2.482750	0.0130373	0.0218135	0.0130373	0.0125357	1.956079e+00	1.1517453	3.322128e+00	Nlrp6	up
60	PCDH7	PCDH7	-0.6628942	0.2660821	-2.491314	0.0127271	0.0104717	0.0127271	0.0125628	5.153577e-01	0.3059280	8.681569e-01	Pcdh7	up
24	CPA3	CPA3	-3.5762611	1.9488975	-1.835017	0.0665031	0.0007919	0.0665031	0.0136850	2.798010e-02	0.0006137	1.275716e+00	Cpa3	down
15	CDH7	CDH7	-0.8340137	0.3472870	-2.401512	0.0163275	0.0091114	0.0163275	0.0140317	4.343026e-01	0.2198777	8.578348e-01	Cdh7	up
2	ABLIM3	ABLIM3	-0.4808436	0.1974873	-2.434808	0.0148997	0.0152889	0.0148997	0.0144433	6.182616e-01	0.4198275	9.104870e-01	Ablim3	up
9	BMP3	BMP3	1.3553265	0.5709786	2.373690	0.0176113	0.0373274	0.0176113	0.0148387	3.878027e+00	1.2664643	1.187487e+01	Bmp3	up
45	LIPG	LIPG	-0.5180286	0.2142283	-2.418115	0.0156012	0.0156964	0.0156012	0.0151243	5.956937e-01	0.3914458	9.065139e-01	Lipg	up
20	CHST15	CHST15	-0.5033978	0.2093893	-2.404124	0.0162113	0.0171423	0.0162113	0.0158504	6.044733e-01	0.4010002	9.111914e-01	Chst15	up
50	MAP6D1	MAP6D1	0.3774339	0.1582533	2.384999	0.0170792	0.0189951	0.0170792	0.0161717	1.458537e+00	1.0695770	1.988946e+00	Map6d1	up
67	PPP2R2B	PPP2R2B	-0.8738006	0.3636238	-2.403035	0.0162596	0.0143470	0.0162596	0.0162598	4.173623e-01	0.2046426	8.511975e-01	Ppp2r2b	up
53	MGAT4C	MGAT4C	-1.3967395	0.5768181	-2.421456	0.0154585	0.0077684	0.0154585	0.0173673	2.474023e-01	0.0798758	7.662883e-01	Mgat4c	up
49	LUZP2	LUZP2	-0.5286152	0.2259100	-2.339937	0.0192870	0.0215066	0.0192870	0.0185859	5.894206e-01	0.3785562	9.177414e-01	Luzp2	up
22	CLMN	CLMN	0.6592381	0.2808949	2.346921	0.0189293	0.0300935	0.0189293	0.0196584	1.933319e+00	1.1148214	3.352753e+00	Clmn	up
79	SPOCK3	SPOCK3	0.5432691	0.2349925	2.311857	0.0207855	0.0283806	0.0207855	0.0197538	1.721626e+00	1.0862075	2.728756e+00	Spock3	up
70	RNF32	RNF32	-0.8573740	0.3707326	-2.312648	0.0207420	0.0208589	0.0207420	0.0203103	4.242748e-01	0.2051536	8.774358e-01	Rnf32	up
59	NSUN7	NSUN7	3.4739776	1.5269652	2.275086	0.0229008	0.0292430	0.0229008	0.0214978	3.226482e+01	1.6179837	6.434050e+02	Nsun7	up
89	TTLL7	TTLL7	0.5323731	0.2360615	2.255231	0.0241189	0.0273676	0.0241189	0.0242335	1.702969e+00	1.0721876	2.704847e+00	Ttll7	up
7	ARHGAP8	ARHGAP8	20.8761762	9.4024620	2.220288	0.0263992	0.0399771	0.0263992	0.0246239	1.165220e+09	11.5616004	1.174352e+17	Arhgap8	down
82	TGM3	TGM3	-4.2363329	1.9422468	-2.181151	0.0291723	0.0073239	0.0291723	0.0251856	1.446050e-02	0.0003213	6.507699e-01	Tgm3	up
71	SERINC2	SERINC2	0.4735774	0.2137832	2.215223	0.0267448	0.0318912	0.0267448	0.0261266	1.605728e+00	1.0560865	2.441432e+00	Serinc2	up
55	MUSK	MUSK	14.1949811	6.5867212	2.155091	0.0311547	0.0678555	0.0311547	0.0279285	1.461511e+06	3.6155532	5.907847e+11	Musk	up
12	CCDC74B	CCDC74B	-0.5455931	0.2493796	-2.187802	0.0286840	0.0294507	0.0286840	0.0283321	5.794980e-01	0.3554509	9.447659e-01	Ccdc74a	up
42	KCNG1	KCNG1	-0.4093191	0.1876366	-2.181446	0.0291504	0.0208728	0.0291504	0.0291734	6.641023e-01	0.4597465	9.592936e-01	Kcng1	up
28	FAM110B	FAM110B	-0.4469752	0.2066142	-2.163333	0.0305156	0.0322178	0.0305156	0.0297200	6.395597e-01	0.4265901	9.588517e-01	Fam110b	up
68	PRSS35	PRSS35	-0.2598632	0.1208744	-2.149861	0.0315662	0.0362531	0.0315662	0.0299232	7.711571e-01	0.6084913	9.773077e-01	Prss35	up
27	EFCAB6	EFCAB6	-4.6697434	2.1733079	-2.148680	0.0316598	0.0230073	0.0316598	0.0302239	9.374700e-03	0.0001324	6.635586e-01	Efcab6	up
40	INHBA	INHBA	-0.7294275	0.3291556	-2.216057	0.0266876	0.0184006	0.0266876	0.0302935	4.821850e-01	0.2529507	9.191606e-01	Inhba	up
80	SYT17	SYT17	-0.7200108	0.3371428	-2.135626	0.0327099	0.0303318	0.0327099	0.0319226	4.867470e-01	0.2513778	9.424965e-01	Syt17	up
26	CRYBB1	CRYBB1	-0.6315141	0.2924614	-2.159307	0.0308263	0.0275145	0.0308263	0.0323952	5.317860e-01	0.2997735	9.433667e-01	Crybb1	up
51	MEIG1	MEIG1	-1.5568552	0.7345368	-2.119506	0.0340477	0.0203682	0.0340477	0.0328155	2.107979e-01	0.0499606	8.894166e-01	Meig1	up
87	TRPC1	TRPC1	-0.9133696	0.4337654	-2.105676	0.0352325	0.0361240	0.0352325	0.0336084	4.011702e-01	0.1714379	9.387510e-01	Trpc1	up
88	TTLL11	TTLL11	1.6033388	0.7533240	2.128352	0.0333079	0.0457185	0.0333079	0.0338183	4.969597e+00	1.1352478	2.175463e+01	Ttll11	up
37	GRIA3	GRIA3	-0.5537059	0.2629723	-2.105567	0.0352420	0.0362229	0.0352420	0.0339876	5.748157e-01	0.3433098	9.624341e-01	Gria3	up
78	SPHKAP	SPHKAP	-0.3948747	0.1885112	-2.094701	0.0361976	0.0354954	0.0361976	0.0350410	6.737645e-01	0.4656365	9.749204e-01	Sphkap	up
17	CES1	CES1	-1.2365117	0.6037801	-2.047950	0.0405649	0.0117912	0.0405649	0.0353114	2.903954e-01	0.0889306	9.482620e-01	Ces1d	up
92	WNT4	WNT4	-0.8323685	0.4111895	-2.024294	0.0429399	0.0156938	0.0429399	0.0364697	4.350177e-01	0.1943130	9.738950e-01	Wnt4	up
29	FAM135B	FAM135B	-1.1288911	0.5417063	-2.083954	0.0371643	0.0296138	0.0371643	0.0366978	3.233917e-01	0.1118478	9.350398e-01	Fam135b	up
57	NIPAL3	NIPAL3	0.3346470	0.1612557	2.075257	0.0379627	0.0390300	0.0379627	0.0369967	1.397447e+00	1.0187656	1.916887e+00	Nipal3	up
14	CCL27	CCL27	-8.0296337	4.5567387	-1.762145	0.0780448	0.0069579	0.0780448	0.0373252	3.257000e-04	0.0000000	2.463074e+00	Ccl27a	up
54	MT3	MT3	0.3041427	0.1425664	2.133341	0.0328967	0.0234258	0.0328967	0.0395999	1.355462e+00	1.0250258	1.792422e+00	Mt3	up
47	LRRC6	LRRC6	-1.0838316	0.5327818	-2.034288	0.0419226	0.0388757	0.0419226	0.0396194	3.382968e-01	0.1190675	9.611754e-01	Lrrc6	up
81	TENM4	TENM4	-0.6701993	0.3295016	-2.033979	0.0419538	0.0392560	0.0419538	0.0413113	5.116066e-01	0.2682031	9.759070e-01	Tenm4	up
5	ALDOC	ALDOC	-0.3064586	0.1514231	-2.023857	0.0429849	0.0525149	0.0429849	0.0425914	7.360490e-01	0.5470351	9.903718e-01	Aldoc	up
69	RAPGEF5	RAPGEF5	0.3193432	0.1604457	1.990350	0.0465524	0.0524216	0.0465524	0.0445547	1.376224e+00	1.0048872	1.884780e+00	Rapgef5	up
43	LDB3	LDB3	0.3834987	0.1921256	1.996083	0.0459248	0.0536589	0.0459248	0.0447002	1.467410e+00	1.0069636	2.138400e+00	Ldb3	up
33	GDF10	GDF10	-0.2476631	0.1253271	-1.976134	0.0481396	0.0394339	0.0481396	0.0457862	7.806229e-01	0.6106083	9.979755e-01	Gdf10	up
84	TPPP	TPPP	0.2895090	0.1455712	1.988779	0.0467256	0.0504267	0.0467256	0.0459345	1.335771e+00	1.0042035	1.776817e+00	Tppp	up
66	PPIL6	PPIL6	-0.8324625	0.4144059	-2.008809	0.0445573	0.0400225	0.0445573	0.0463260	4.349768e-01	0.1930737	9.799617e-01	Ppil6	up
23	CNTNAP4	CNTNAP4	0.4244264	0.2146225	1.977548	0.0479797	0.0526664	0.0479797	0.0466958	1.528713e+00	1.0037811	2.328161e+00	Cntnap4	up
31	FRY	FRY	-0.6944304	0.3511521	-1.977577	0.0479764	0.0486039	0.0479764	0.0472073	4.993588e-01	0.2509062	9.938342e-01	Fry	up
41	IRX2	IRX2	-0.3255989	0.1648842	-1.974713	0.0483007	0.0587783	0.0483007	0.0477633	7.220948e-01	0.5226904	9.975711e-01	Irx2	down
11	CARTPT	CARTPT	0.1630698	0.0843582	1.933065	0.0532282	0.0819939	0.0532282	0.0496218	1.177119e+00	0.9977334	1.388756e+00	Cartpt	up
83	TMCO5A	TMCO5A	82.6409564	43.6960941	1.891266	0.0585888	0.1037047	0.0585888	0.0498658	7.771616e+35	0.0496968	1.215330e+73	Tmco5	up

IDH_NOCODEL

Gene-sets considered

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Table genes

	Variable	Term	Beta	StandardError	Z	P	LRT	Wald	LogRank	HR	HRlower	HRupper	mm	status
36	GPR139	GPR139	5.1595162	1.0707833	4.818450	0.0000014	0.0000396	0.0000014	0.0000000	1.740802e+02	21.3450416	1.419717e+03	Gpr139	up
61	PCDHGA3	PCDHGA3	0.7508024	0.2053482	3.656241	0.0002559	0.0025701	0.0002559	0.0000236	2.118699e+00	1.4166959	3.168560e+00	Pcdhga3	up
18	CHIC2	CHIC2	1.3148603	0.3211465	4.094269	0.0000424	0.0002660	0.0000424	0.0000446	3.724231e+00	1.9846144	6.988710e+00	Chic2	down
63	PHKG1	PHKG1	-0.6406674	0.1684263	-3.803845	0.0001425	0.0002338	0.0001425	0.0001123	5.269406e-01	0.3787887	7.330378e-01	Phkg1	up
3	ADAMTS3	ADAMTS3	3.2224925	1.0514520	3.064802	0.0021781	0.0093278	0.0021781	0.0001595	2.509058e+01	3.1953107	1.970191e+02	Adamts3	up
21	CLEC18A	CLEC18A	2.8000255	0.7790372	3.594213	0.0003254	0.0014044	0.0003254	0.0001713	1.644507e+01	3.5720534	7.571001e+01	Clec18a	up
46	LIX1	LIX1	-0.6899061	0.1972237	-3.498089	0.0004686	0.0005864	0.0004686	0.0003863	5.016232e-01	0.3408007	7.383372e-01	Lix1	up
72	SFTPC	SFTPC	0.7150386	0.2109331	3.389884	0.0006992	0.0007212	0.0006992	0.0005360	2.044266e+00	1.3520438	3.090892e+00	Sftpc	up
62	PCDHGA8	PCDHGA8	5.2362662	1.6538533	3.166101	0.0015450	0.0096278	0.0015450	0.0011135	1.879670e+02	7.3505362	4.806666e+03	Pcdhga8	up
93	ZBTB8B	ZBTB8B	1.1365043	0.3520922	3.227860	0.0012472	0.0015945	0.0012472	0.0011193	3.115857e+00	1.5627018	6.212679e+00	Zbtb8b	up
48	LRRK2	LRRK2	0.5470006	0.1760081	3.107815	0.0018848	0.0038480	0.0018848	0.0016209	1.728062e+00	1.2238861	2.439932e+00	Lrrk2	up
73	SH3GL2	SH3GL2	-0.7681192	0.2405062	-3.193760	0.0014043	0.0017402	0.0014043	0.0017373	4.638847e-01	0.2895282	7.432404e-01	Sh3gl2	up
56	MYH1	MYH1	6.4885350	2.3189710	2.798023	0.0051416	0.0245868	0.0051416	0.0019006	6.575594e+02	6.9826986	6.192224e+04	Myh1	up
10	BVES	BVES	0.6492014	0.2109948	3.076860	0.0020919	0.0034852	0.0020919	0.0022376	1.914012e+00	1.2657428	2.894301e+00	Bves	up
30	FAM186B	FAM186B	3.6808737	1.2262259	3.001791	0.0026840	0.0048851	0.0026840	0.0028607	3.968105e+01	3.5877136	4.388828e+02	Fam186b	up
77	SMIM1	SMIM1	0.8812849	0.3007913	2.929889	0.0033908	0.0049659	0.0033908	0.0032167	2.414000e+00	1.3387614	4.352825e+00	Smim1	up
4	AHCYL2	AHCYL2	-0.6577339	0.2262623	-2.906954	0.0036497	0.0028521	0.0036497	0.0033225	5.180239e-01	0.3324719	8.071320e-01	Ahcyl2	up
35	GLT8D2	GLT8D2	-2.1935510	0.7573641	-2.896297	0.0037760	0.0018451	0.0037760	0.0034438	1.115200e-01	0.0252746	4.920649e-01	Glt8d2	up
16	CEP135	CEP135	0.9612037	0.3279532	2.930917	0.0033796	0.0113210	0.0033796	0.0035540	2.614842e+00	1.3749635	4.972786e+00	Cep135	down
64	PLCXD1	PLCXD1	0.7187168	0.2420552	2.969226	0.0029855	0.0042069	0.0029855	0.0038072	2.051799e+00	1.2767238	3.297407e+00	Plcxd1	up
1	ABCA8	ABCA8	0.4570804	0.1554996	2.939431	0.0032882	0.0086596	0.0032882	0.0038081	1.579456e+00	1.1645174	2.142244e+00	Abca8b	up
38	HHATL	HHATL	0.3972220	0.1379059	2.880384	0.0039719	0.0037733	0.0039719	0.0039397	1.487686e+00	1.1353391	1.949383e+00	Hhatl	up
19	CHRM5	CHRM5	1.9356194	0.6916367	2.798607	0.0051324	0.0113490	0.0051324	0.0039951	6.928334e+00	1.7861035	2.687516e+01	Chrm5	up
8	BARX2	BARX2	4.2196030	1.5075048	2.799064	0.0051251	0.0101462	0.0051251	0.0043039	6.800648e+01	3.5429083	1.305391e+03	Barx2	up
52	METTL11B	METTL11B	2.5058448	0.9684965	2.587356	0.0096716	0.0338070	0.0096716	0.0050058	1.225391e+01	1.8360684	8.178248e+01	Mettl11b	up
13	CCDC87	CCDC87	-0.6405216	0.2300130	-2.784719	0.0053574	0.0053539	0.0053574	0.0051444	5.270174e-01	0.3357666	8.272036e-01	Ccdc87	up
44	LGI3	LGI3	0.3468954	0.1262967	2.746671	0.0060204	0.0058834	0.0060204	0.0056087	1.414669e+00	1.1044621	1.812002e+00	Lgi3	up
90	TUB	TUB	-0.5353015	0.1944482	-2.752925	0.0059065	0.0069206	0.0059065	0.0057163	5.854927e-01	0.3999511	8.571092e-01	Tub	up
74	SLC35F4	SLC35F4	7.7687589	3.3957542	2.287786	0.0221500	0.0864739	0.0221500	0.0063834	2.365534e+03	3.0440926	1.838232e+06	Slc35f4	up
85	TPSAB1	TPSAB1	-0.8846744	0.3542311	-2.497450	0.0125090	0.0006903	0.0125090	0.0063899	4.128486e-01	0.2061905	8.266333e-01	Tpsb2	down
39	HHIP	HHIP	0.5059547	0.1893155	2.672548	0.0075278	0.0125895	0.0075278	0.0067012	1.658568e+00	1.1444259	2.403693e+00	Hhip	up
25	CRTAC1	CRTAC1	-0.5325153	0.2040986	-2.609107	0.0090779	0.0096375	0.0090779	0.0088457	5.871263e-01	0.3935523	8.759123e-01	Crtac1	up
32	FXYD7	FXYD7	0.2876284	0.1121605	2.564436	0.0103343	0.0106282	0.0103343	0.0093643	1.333262e+00	1.0701490	1.661065e+00	Fxyd7	up
6	AOX3P	AOX3P	11.3330802	4.4432645	2.550620	0.0107531	0.0331895	0.0107531	0.0097299	8.353995e+04	13.7968724	5.058337e+08	Aox3	up
76	SLCO4A1	SLCO4A1	0.5349134	0.2092046	2.556891	0.0105612	0.0149816	0.0105612	0.0103656	1.707300e+00	1.1330123	2.572677e+00	Slco4a1	up
91	VWC2	VWC2	-0.8658511	0.3444749	-2.513539	0.0119527	0.0076251	0.0119527	0.0104954	4.206934e-01	0.2141648	8.263865e-01	Vwc2	up
34	GLRA3	GLRA3	-0.7538191	0.3011341	-2.503267	0.0123053	0.0079996	0.0123053	0.0114512	4.705660e-01	0.2607922	8.490756e-01	Glra3	up
75	SLC8A3	SLC8A3	-0.6592973	0.2645167	-2.492460	0.0126862	0.0094084	0.0126862	0.0114866	5.172147e-01	0.3079738	8.686161e-01	Slc8a3	up
65	POPDC3	POPDC3	0.4728442	0.1902276	2.485676	0.0129306	0.0187433	0.0129306	0.0117812	1.604551e+00	1.1051763	2.329569e+00	Popdc3	up
86	TPSB2	TPSB2	-0.8013200	0.3290348	-2.435365	0.0148768	0.0022816	0.0148768	0.0118109	4.487363e-01	0.2354595	8.551968e-01	Tpsb2	down
58	NLRP6	NLRP6	0.6709421	0.2702415	2.482750	0.0130373	0.0218135	0.0130373	0.0125357	1.956079e+00	1.1517453	3.322128e+00	Nlrp6	up
60	PCDH7	PCDH7	-0.6628942	0.2660821	-2.491314	0.0127271	0.0104717	0.0127271	0.0125628	5.153577e-01	0.3059280	8.681569e-01	Pcdh7	up
24	CPA3	CPA3	-3.5762611	1.9488975	-1.835017	0.0665031	0.0007919	0.0665031	0.0136850	2.798010e-02	0.0006137	1.275716e+00	Cpa3	down
15	CDH7	CDH7	-0.8340137	0.3472870	-2.401512	0.0163275	0.0091114	0.0163275	0.0140317	4.343026e-01	0.2198777	8.578348e-01	Cdh7	up
2	ABLIM3	ABLIM3	-0.4808436	0.1974873	-2.434808	0.0148997	0.0152889	0.0148997	0.0144433	6.182616e-01	0.4198275	9.104870e-01	Ablim3	up
9	BMP3	BMP3	1.3553265	0.5709786	2.373690	0.0176113	0.0373274	0.0176113	0.0148387	3.878027e+00	1.2664643	1.187487e+01	Bmp3	up
45	LIPG	LIPG	-0.5180286	0.2142283	-2.418115	0.0156012	0.0156964	0.0156012	0.0151243	5.956937e-01	0.3914458	9.065139e-01	Lipg	up
20	CHST15	CHST15	-0.5033978	0.2093893	-2.404124	0.0162113	0.0171423	0.0162113	0.0158504	6.044733e-01	0.4010002	9.111914e-01	Chst15	up
50	MAP6D1	MAP6D1	0.3774339	0.1582533	2.384999	0.0170792	0.0189951	0.0170792	0.0161717	1.458537e+00	1.0695770	1.988946e+00	Map6d1	up
67	PPP2R2B	PPP2R2B	-0.8738006	0.3636238	-2.403035	0.0162596	0.0143470	0.0162596	0.0162598	4.173623e-01	0.2046426	8.511975e-01	Ppp2r2b	up
53	MGAT4C	MGAT4C	-1.3967395	0.5768181	-2.421456	0.0154585	0.0077684	0.0154585	0.0173673	2.474023e-01	0.0798758	7.662883e-01	Mgat4c	up
49	LUZP2	LUZP2	-0.5286152	0.2259100	-2.339937	0.0192870	0.0215066	0.0192870	0.0185859	5.894206e-01	0.3785562	9.177414e-01	Luzp2	up
22	CLMN	CLMN	0.6592381	0.2808949	2.346921	0.0189293	0.0300935	0.0189293	0.0196584	1.933319e+00	1.1148214	3.352753e+00	Clmn	up
79	SPOCK3	SPOCK3	0.5432691	0.2349925	2.311857	0.0207855	0.0283806	0.0207855	0.0197538	1.721626e+00	1.0862075	2.728756e+00	Spock3	up
70	RNF32	RNF32	-0.8573740	0.3707326	-2.312648	0.0207420	0.0208589	0.0207420	0.0203103	4.242748e-01	0.2051536	8.774358e-01	Rnf32	up
59	NSUN7	NSUN7	3.4739776	1.5269652	2.275086	0.0229008	0.0292430	0.0229008	0.0214978	3.226482e+01	1.6179837	6.434050e+02	Nsun7	up
89	TTLL7	TTLL7	0.5323731	0.2360615	2.255231	0.0241189	0.0273676	0.0241189	0.0242335	1.702969e+00	1.0721876	2.704847e+00	Ttll7	up
7	ARHGAP8	ARHGAP8	20.8761762	9.4024620	2.220288	0.0263992	0.0399771	0.0263992	0.0246239	1.165220e+09	11.5616004	1.174352e+17	Arhgap8	down
82	TGM3	TGM3	-4.2363329	1.9422468	-2.181151	0.0291723	0.0073239	0.0291723	0.0251856	1.446050e-02	0.0003213	6.507699e-01	Tgm3	up
71	SERINC2	SERINC2	0.4735774	0.2137832	2.215223	0.0267448	0.0318912	0.0267448	0.0261266	1.605728e+00	1.0560865	2.441432e+00	Serinc2	up
55	MUSK	MUSK	14.1949811	6.5867212	2.155091	0.0311547	0.0678555	0.0311547	0.0279285	1.461511e+06	3.6155532	5.907847e+11	Musk	up
12	CCDC74B	CCDC74B	-0.5455931	0.2493796	-2.187802	0.0286840	0.0294507	0.0286840	0.0283321	5.794980e-01	0.3554509	9.447659e-01	Ccdc74a	up
42	KCNG1	KCNG1	-0.4093191	0.1876366	-2.181446	0.0291504	0.0208728	0.0291504	0.0291734	6.641023e-01	0.4597465	9.592936e-01	Kcng1	up
28	FAM110B	FAM110B	-0.4469752	0.2066142	-2.163333	0.0305156	0.0322178	0.0305156	0.0297200	6.395597e-01	0.4265901	9.588517e-01	Fam110b	up
68	PRSS35	PRSS35	-0.2598632	0.1208744	-2.149861	0.0315662	0.0362531	0.0315662	0.0299232	7.711571e-01	0.6084913	9.773077e-01	Prss35	up
27	EFCAB6	EFCAB6	-4.6697434	2.1733079	-2.148680	0.0316598	0.0230073	0.0316598	0.0302239	9.374700e-03	0.0001324	6.635586e-01	Efcab6	up
40	INHBA	INHBA	-0.7294275	0.3291556	-2.216057	0.0266876	0.0184006	0.0266876	0.0302935	4.821850e-01	0.2529507	9.191606e-01	Inhba	up
80	SYT17	SYT17	-0.7200108	0.3371428	-2.135626	0.0327099	0.0303318	0.0327099	0.0319226	4.867470e-01	0.2513778	9.424965e-01	Syt17	up
26	CRYBB1	CRYBB1	-0.6315141	0.2924614	-2.159307	0.0308263	0.0275145	0.0308263	0.0323952	5.317860e-01	0.2997735	9.433667e-01	Crybb1	up
51	MEIG1	MEIG1	-1.5568552	0.7345368	-2.119506	0.0340477	0.0203682	0.0340477	0.0328155	2.107979e-01	0.0499606	8.894166e-01	Meig1	up
87	TRPC1	TRPC1	-0.9133696	0.4337654	-2.105676	0.0352325	0.0361240	0.0352325	0.0336084	4.011702e-01	0.1714379	9.387510e-01	Trpc1	up
88	TTLL11	TTLL11	1.6033388	0.7533240	2.128352	0.0333079	0.0457185	0.0333079	0.0338183	4.969597e+00	1.1352478	2.175463e+01	Ttll11	up
37	GRIA3	GRIA3	-0.5537059	0.2629723	-2.105567	0.0352420	0.0362229	0.0352420	0.0339876	5.748157e-01	0.3433098	9.624341e-01	Gria3	up
78	SPHKAP	SPHKAP	-0.3948747	0.1885112	-2.094701	0.0361976	0.0354954	0.0361976	0.0350410	6.737645e-01	0.4656365	9.749204e-01	Sphkap	up
17	CES1	CES1	-1.2365117	0.6037801	-2.047950	0.0405649	0.0117912	0.0405649	0.0353114	2.903954e-01	0.0889306	9.482620e-01	Ces1d	up
92	WNT4	WNT4	-0.8323685	0.4111895	-2.024294	0.0429399	0.0156938	0.0429399	0.0364697	4.350177e-01	0.1943130	9.738950e-01	Wnt4	up
29	FAM135B	FAM135B	-1.1288911	0.5417063	-2.083954	0.0371643	0.0296138	0.0371643	0.0366978	3.233917e-01	0.1118478	9.350398e-01	Fam135b	up
57	NIPAL3	NIPAL3	0.3346470	0.1612557	2.075257	0.0379627	0.0390300	0.0379627	0.0369967	1.397447e+00	1.0187656	1.916887e+00	Nipal3	up
14	CCL27	CCL27	-8.0296337	4.5567387	-1.762145	0.0780448	0.0069579	0.0780448	0.0373252	3.257000e-04	0.0000000	2.463074e+00	Ccl27a	up
54	MT3	MT3	0.3041427	0.1425664	2.133341	0.0328967	0.0234258	0.0328967	0.0395999	1.355462e+00	1.0250258	1.792422e+00	Mt3	up
47	LRRC6	LRRC6	-1.0838316	0.5327818	-2.034288	0.0419226	0.0388757	0.0419226	0.0396194	3.382968e-01	0.1190675	9.611754e-01	Lrrc6	up
81	TENM4	TENM4	-0.6701993	0.3295016	-2.033979	0.0419538	0.0392560	0.0419538	0.0413113	5.116066e-01	0.2682031	9.759070e-01	Tenm4	up
5	ALDOC	ALDOC	-0.3064586	0.1514231	-2.023857	0.0429849	0.0525149	0.0429849	0.0425914	7.360490e-01	0.5470351	9.903718e-01	Aldoc	up
69	RAPGEF5	RAPGEF5	0.3193432	0.1604457	1.990350	0.0465524	0.0524216	0.0465524	0.0445547	1.376224e+00	1.0048872	1.884780e+00	Rapgef5	up
43	LDB3	LDB3	0.3834987	0.1921256	1.996083	0.0459248	0.0536589	0.0459248	0.0447002	1.467410e+00	1.0069636	2.138400e+00	Ldb3	up
33	GDF10	GDF10	-0.2476631	0.1253271	-1.976134	0.0481396	0.0394339	0.0481396	0.0457862	7.806229e-01	0.6106083	9.979755e-01	Gdf10	up
84	TPPP	TPPP	0.2895090	0.1455712	1.988779	0.0467256	0.0504267	0.0467256	0.0459345	1.335771e+00	1.0042035	1.776817e+00	Tppp	up
66	PPIL6	PPIL6	-0.8324625	0.4144059	-2.008809	0.0445573	0.0400225	0.0445573	0.0463260	4.349768e-01	0.1930737	9.799617e-01	Ppil6	up
23	CNTNAP4	CNTNAP4	0.4244264	0.2146225	1.977548	0.0479797	0.0526664	0.0479797	0.0466958	1.528713e+00	1.0037811	2.328161e+00	Cntnap4	up
31	FRY	FRY	-0.6944304	0.3511521	-1.977577	0.0479764	0.0486039	0.0479764	0.0472073	4.993588e-01	0.2509062	9.938342e-01	Fry	up
41	IRX2	IRX2	-0.3255989	0.1648842	-1.974713	0.0483007	0.0587783	0.0483007	0.0477633	7.220948e-01	0.5226904	9.975711e-01	Irx2	down
11	CARTPT	CARTPT	0.1630698	0.0843582	1.933065	0.0532282	0.0819939	0.0532282	0.0496218	1.177119e+00	0.9977334	1.388756e+00	Cartpt	up
83	TMCO5A	TMCO5A	82.6409564	43.6960941	1.891266	0.0585888	0.1037047	0.0585888	0.0498658	7.771616e+35	0.0496968	1.215330e+73	Tmco5	up

GBM_LGG

Gene-sets considered

UP and DOWN

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Table genes

	Variable	Term	Beta	StandardError	Z	P	LRT	Wald	LogRank	HR	HRlower	HRupper	mm	status
36	GPR139	GPR139	5.1595162	1.0707833	4.818450	0.0000014	0.0000396	0.0000014	0.0000000	1.740802e+02	21.3450416	1.419717e+03	Gpr139	up
61	PCDHGA3	PCDHGA3	0.7508024	0.2053482	3.656241	0.0002559	0.0025701	0.0002559	0.0000236	2.118699e+00	1.4166959	3.168560e+00	Pcdhga3	up
18	CHIC2	CHIC2	1.3148603	0.3211465	4.094269	0.0000424	0.0002660	0.0000424	0.0000446	3.724231e+00	1.9846144	6.988710e+00	Chic2	down
63	PHKG1	PHKG1	-0.6406674	0.1684263	-3.803845	0.0001425	0.0002338	0.0001425	0.0001123	5.269406e-01	0.3787887	7.330378e-01	Phkg1	up
3	ADAMTS3	ADAMTS3	3.2224925	1.0514520	3.064802	0.0021781	0.0093278	0.0021781	0.0001595	2.509058e+01	3.1953107	1.970191e+02	Adamts3	up
21	CLEC18A	CLEC18A	2.8000255	0.7790372	3.594213	0.0003254	0.0014044	0.0003254	0.0001713	1.644507e+01	3.5720534	7.571001e+01	Clec18a	up
46	LIX1	LIX1	-0.6899061	0.1972237	-3.498089	0.0004686	0.0005864	0.0004686	0.0003863	5.016232e-01	0.3408007	7.383372e-01	Lix1	up
72	SFTPC	SFTPC	0.7150386	0.2109331	3.389884	0.0006992	0.0007212	0.0006992	0.0005360	2.044266e+00	1.3520438	3.090892e+00	Sftpc	up
62	PCDHGA8	PCDHGA8	5.2362662	1.6538533	3.166101	0.0015450	0.0096278	0.0015450	0.0011135	1.879670e+02	7.3505362	4.806666e+03	Pcdhga8	up
93	ZBTB8B	ZBTB8B	1.1365043	0.3520922	3.227860	0.0012472	0.0015945	0.0012472	0.0011193	3.115857e+00	1.5627018	6.212679e+00	Zbtb8b	up
48	LRRK2	LRRK2	0.5470006	0.1760081	3.107815	0.0018848	0.0038480	0.0018848	0.0016209	1.728062e+00	1.2238861	2.439932e+00	Lrrk2	up
73	SH3GL2	SH3GL2	-0.7681192	0.2405062	-3.193760	0.0014043	0.0017402	0.0014043	0.0017373	4.638847e-01	0.2895282	7.432404e-01	Sh3gl2	up
56	MYH1	MYH1	6.4885350	2.3189710	2.798023	0.0051416	0.0245868	0.0051416	0.0019006	6.575594e+02	6.9826986	6.192224e+04	Myh1	up
10	BVES	BVES	0.6492014	0.2109948	3.076860	0.0020919	0.0034852	0.0020919	0.0022376	1.914012e+00	1.2657428	2.894301e+00	Bves	up
30	FAM186B	FAM186B	3.6808737	1.2262259	3.001791	0.0026840	0.0048851	0.0026840	0.0028607	3.968105e+01	3.5877136	4.388828e+02	Fam186b	up
77	SMIM1	SMIM1	0.8812849	0.3007913	2.929889	0.0033908	0.0049659	0.0033908	0.0032167	2.414000e+00	1.3387614	4.352825e+00	Smim1	up
4	AHCYL2	AHCYL2	-0.6577339	0.2262623	-2.906954	0.0036497	0.0028521	0.0036497	0.0033225	5.180239e-01	0.3324719	8.071320e-01	Ahcyl2	up
35	GLT8D2	GLT8D2	-2.1935510	0.7573641	-2.896297	0.0037760	0.0018451	0.0037760	0.0034438	1.115200e-01	0.0252746	4.920649e-01	Glt8d2	up
16	CEP135	CEP135	0.9612037	0.3279532	2.930917	0.0033796	0.0113210	0.0033796	0.0035540	2.614842e+00	1.3749635	4.972786e+00	Cep135	down
64	PLCXD1	PLCXD1	0.7187168	0.2420552	2.969226	0.0029855	0.0042069	0.0029855	0.0038072	2.051799e+00	1.2767238	3.297407e+00	Plcxd1	up
1	ABCA8	ABCA8	0.4570804	0.1554996	2.939431	0.0032882	0.0086596	0.0032882	0.0038081	1.579456e+00	1.1645174	2.142244e+00	Abca8b	up
38	HHATL	HHATL	0.3972220	0.1379059	2.880384	0.0039719	0.0037733	0.0039719	0.0039397	1.487686e+00	1.1353391	1.949383e+00	Hhatl	up
19	CHRM5	CHRM5	1.9356194	0.6916367	2.798607	0.0051324	0.0113490	0.0051324	0.0039951	6.928334e+00	1.7861035	2.687516e+01	Chrm5	up
8	BARX2	BARX2	4.2196030	1.5075048	2.799064	0.0051251	0.0101462	0.0051251	0.0043039	6.800648e+01	3.5429083	1.305391e+03	Barx2	up
52	METTL11B	METTL11B	2.5058448	0.9684965	2.587356	0.0096716	0.0338070	0.0096716	0.0050058	1.225391e+01	1.8360684	8.178248e+01	Mettl11b	up
13	CCDC87	CCDC87	-0.6405216	0.2300130	-2.784719	0.0053574	0.0053539	0.0053574	0.0051444	5.270174e-01	0.3357666	8.272036e-01	Ccdc87	up
44	LGI3	LGI3	0.3468954	0.1262967	2.746671	0.0060204	0.0058834	0.0060204	0.0056087	1.414669e+00	1.1044621	1.812002e+00	Lgi3	up
90	TUB	TUB	-0.5353015	0.1944482	-2.752925	0.0059065	0.0069206	0.0059065	0.0057163	5.854927e-01	0.3999511	8.571092e-01	Tub	up
74	SLC35F4	SLC35F4	7.7687589	3.3957542	2.287786	0.0221500	0.0864739	0.0221500	0.0063834	2.365534e+03	3.0440926	1.838232e+06	Slc35f4	up
85	TPSAB1	TPSAB1	-0.8846744	0.3542311	-2.497450	0.0125090	0.0006903	0.0125090	0.0063899	4.128486e-01	0.2061905	8.266333e-01	Tpsb2	down
39	HHIP	HHIP	0.5059547	0.1893155	2.672548	0.0075278	0.0125895	0.0075278	0.0067012	1.658568e+00	1.1444259	2.403693e+00	Hhip	up
25	CRTAC1	CRTAC1	-0.5325153	0.2040986	-2.609107	0.0090779	0.0096375	0.0090779	0.0088457	5.871263e-01	0.3935523	8.759123e-01	Crtac1	up
32	FXYD7	FXYD7	0.2876284	0.1121605	2.564436	0.0103343	0.0106282	0.0103343	0.0093643	1.333262e+00	1.0701490	1.661065e+00	Fxyd7	up
6	AOX3P	AOX3P	11.3330802	4.4432645	2.550620	0.0107531	0.0331895	0.0107531	0.0097299	8.353995e+04	13.7968724	5.058337e+08	Aox3	up
76	SLCO4A1	SLCO4A1	0.5349134	0.2092046	2.556891	0.0105612	0.0149816	0.0105612	0.0103656	1.707300e+00	1.1330123	2.572677e+00	Slco4a1	up
91	VWC2	VWC2	-0.8658511	0.3444749	-2.513539	0.0119527	0.0076251	0.0119527	0.0104954	4.206934e-01	0.2141648	8.263865e-01	Vwc2	up
34	GLRA3	GLRA3	-0.7538191	0.3011341	-2.503267	0.0123053	0.0079996	0.0123053	0.0114512	4.705660e-01	0.2607922	8.490756e-01	Glra3	up
75	SLC8A3	SLC8A3	-0.6592973	0.2645167	-2.492460	0.0126862	0.0094084	0.0126862	0.0114866	5.172147e-01	0.3079738	8.686161e-01	Slc8a3	up
65	POPDC3	POPDC3	0.4728442	0.1902276	2.485676	0.0129306	0.0187433	0.0129306	0.0117812	1.604551e+00	1.1051763	2.329569e+00	Popdc3	up
86	TPSB2	TPSB2	-0.8013200	0.3290348	-2.435365	0.0148768	0.0022816	0.0148768	0.0118109	4.487363e-01	0.2354595	8.551968e-01	Tpsb2	down
58	NLRP6	NLRP6	0.6709421	0.2702415	2.482750	0.0130373	0.0218135	0.0130373	0.0125357	1.956079e+00	1.1517453	3.322128e+00	Nlrp6	up
60	PCDH7	PCDH7	-0.6628942	0.2660821	-2.491314	0.0127271	0.0104717	0.0127271	0.0125628	5.153577e-01	0.3059280	8.681569e-01	Pcdh7	up
24	CPA3	CPA3	-3.5762611	1.9488975	-1.835017	0.0665031	0.0007919	0.0665031	0.0136850	2.798010e-02	0.0006137	1.275716e+00	Cpa3	down
15	CDH7	CDH7	-0.8340137	0.3472870	-2.401512	0.0163275	0.0091114	0.0163275	0.0140317	4.343026e-01	0.2198777	8.578348e-01	Cdh7	up
2	ABLIM3	ABLIM3	-0.4808436	0.1974873	-2.434808	0.0148997	0.0152889	0.0148997	0.0144433	6.182616e-01	0.4198275	9.104870e-01	Ablim3	up
9	BMP3	BMP3	1.3553265	0.5709786	2.373690	0.0176113	0.0373274	0.0176113	0.0148387	3.878027e+00	1.2664643	1.187487e+01	Bmp3	up
45	LIPG	LIPG	-0.5180286	0.2142283	-2.418115	0.0156012	0.0156964	0.0156012	0.0151243	5.956937e-01	0.3914458	9.065139e-01	Lipg	up
20	CHST15	CHST15	-0.5033978	0.2093893	-2.404124	0.0162113	0.0171423	0.0162113	0.0158504	6.044733e-01	0.4010002	9.111914e-01	Chst15	up
50	MAP6D1	MAP6D1	0.3774339	0.1582533	2.384999	0.0170792	0.0189951	0.0170792	0.0161717	1.458537e+00	1.0695770	1.988946e+00	Map6d1	up
67	PPP2R2B	PPP2R2B	-0.8738006	0.3636238	-2.403035	0.0162596	0.0143470	0.0162596	0.0162598	4.173623e-01	0.2046426	8.511975e-01	Ppp2r2b	up
53	MGAT4C	MGAT4C	-1.3967395	0.5768181	-2.421456	0.0154585	0.0077684	0.0154585	0.0173673	2.474023e-01	0.0798758	7.662883e-01	Mgat4c	up
49	LUZP2	LUZP2	-0.5286152	0.2259100	-2.339937	0.0192870	0.0215066	0.0192870	0.0185859	5.894206e-01	0.3785562	9.177414e-01	Luzp2	up
22	CLMN	CLMN	0.6592381	0.2808949	2.346921	0.0189293	0.0300935	0.0189293	0.0196584	1.933319e+00	1.1148214	3.352753e+00	Clmn	up
79	SPOCK3	SPOCK3	0.5432691	0.2349925	2.311857	0.0207855	0.0283806	0.0207855	0.0197538	1.721626e+00	1.0862075	2.728756e+00	Spock3	up
70	RNF32	RNF32	-0.8573740	0.3707326	-2.312648	0.0207420	0.0208589	0.0207420	0.0203103	4.242748e-01	0.2051536	8.774358e-01	Rnf32	up
59	NSUN7	NSUN7	3.4739776	1.5269652	2.275086	0.0229008	0.0292430	0.0229008	0.0214978	3.226482e+01	1.6179837	6.434050e+02	Nsun7	up
89	TTLL7	TTLL7	0.5323731	0.2360615	2.255231	0.0241189	0.0273676	0.0241189	0.0242335	1.702969e+00	1.0721876	2.704847e+00	Ttll7	up
7	ARHGAP8	ARHGAP8	20.8761762	9.4024620	2.220288	0.0263992	0.0399771	0.0263992	0.0246239	1.165220e+09	11.5616004	1.174352e+17	Arhgap8	down
82	TGM3	TGM3	-4.2363329	1.9422468	-2.181151	0.0291723	0.0073239	0.0291723	0.0251856	1.446050e-02	0.0003213	6.507699e-01	Tgm3	up
71	SERINC2	SERINC2	0.4735774	0.2137832	2.215223	0.0267448	0.0318912	0.0267448	0.0261266	1.605728e+00	1.0560865	2.441432e+00	Serinc2	up
55	MUSK	MUSK	14.1949811	6.5867212	2.155091	0.0311547	0.0678555	0.0311547	0.0279285	1.461511e+06	3.6155532	5.907847e+11	Musk	up
12	CCDC74B	CCDC74B	-0.5455931	0.2493796	-2.187802	0.0286840	0.0294507	0.0286840	0.0283321	5.794980e-01	0.3554509	9.447659e-01	Ccdc74a	up
42	KCNG1	KCNG1	-0.4093191	0.1876366	-2.181446	0.0291504	0.0208728	0.0291504	0.0291734	6.641023e-01	0.4597465	9.592936e-01	Kcng1	up
28	FAM110B	FAM110B	-0.4469752	0.2066142	-2.163333	0.0305156	0.0322178	0.0305156	0.0297200	6.395597e-01	0.4265901	9.588517e-01	Fam110b	up
68	PRSS35	PRSS35	-0.2598632	0.1208744	-2.149861	0.0315662	0.0362531	0.0315662	0.0299232	7.711571e-01	0.6084913	9.773077e-01	Prss35	up
27	EFCAB6	EFCAB6	-4.6697434	2.1733079	-2.148680	0.0316598	0.0230073	0.0316598	0.0302239	9.374700e-03	0.0001324	6.635586e-01	Efcab6	up
40	INHBA	INHBA	-0.7294275	0.3291556	-2.216057	0.0266876	0.0184006	0.0266876	0.0302935	4.821850e-01	0.2529507	9.191606e-01	Inhba	up
80	SYT17	SYT17	-0.7200108	0.3371428	-2.135626	0.0327099	0.0303318	0.0327099	0.0319226	4.867470e-01	0.2513778	9.424965e-01	Syt17	up
26	CRYBB1	CRYBB1	-0.6315141	0.2924614	-2.159307	0.0308263	0.0275145	0.0308263	0.0323952	5.317860e-01	0.2997735	9.433667e-01	Crybb1	up
51	MEIG1	MEIG1	-1.5568552	0.7345368	-2.119506	0.0340477	0.0203682	0.0340477	0.0328155	2.107979e-01	0.0499606	8.894166e-01	Meig1	up
87	TRPC1	TRPC1	-0.9133696	0.4337654	-2.105676	0.0352325	0.0361240	0.0352325	0.0336084	4.011702e-01	0.1714379	9.387510e-01	Trpc1	up
88	TTLL11	TTLL11	1.6033388	0.7533240	2.128352	0.0333079	0.0457185	0.0333079	0.0338183	4.969597e+00	1.1352478	2.175463e+01	Ttll11	up
37	GRIA3	GRIA3	-0.5537059	0.2629723	-2.105567	0.0352420	0.0362229	0.0352420	0.0339876	5.748157e-01	0.3433098	9.624341e-01	Gria3	up
78	SPHKAP	SPHKAP	-0.3948747	0.1885112	-2.094701	0.0361976	0.0354954	0.0361976	0.0350410	6.737645e-01	0.4656365	9.749204e-01	Sphkap	up
17	CES1	CES1	-1.2365117	0.6037801	-2.047950	0.0405649	0.0117912	0.0405649	0.0353114	2.903954e-01	0.0889306	9.482620e-01	Ces1d	up
92	WNT4	WNT4	-0.8323685	0.4111895	-2.024294	0.0429399	0.0156938	0.0429399	0.0364697	4.350177e-01	0.1943130	9.738950e-01	Wnt4	up
29	FAM135B	FAM135B	-1.1288911	0.5417063	-2.083954	0.0371643	0.0296138	0.0371643	0.0366978	3.233917e-01	0.1118478	9.350398e-01	Fam135b	up
57	NIPAL3	NIPAL3	0.3346470	0.1612557	2.075257	0.0379627	0.0390300	0.0379627	0.0369967	1.397447e+00	1.0187656	1.916887e+00	Nipal3	up
14	CCL27	CCL27	-8.0296337	4.5567387	-1.762145	0.0780448	0.0069579	0.0780448	0.0373252	3.257000e-04	0.0000000	2.463074e+00	Ccl27a	up
54	MT3	MT3	0.3041427	0.1425664	2.133341	0.0328967	0.0234258	0.0328967	0.0395999	1.355462e+00	1.0250258	1.792422e+00	Mt3	up
47	LRRC6	LRRC6	-1.0838316	0.5327818	-2.034288	0.0419226	0.0388757	0.0419226	0.0396194	3.382968e-01	0.1190675	9.611754e-01	Lrrc6	up
81	TENM4	TENM4	-0.6701993	0.3295016	-2.033979	0.0419538	0.0392560	0.0419538	0.0413113	5.116066e-01	0.2682031	9.759070e-01	Tenm4	up
5	ALDOC	ALDOC	-0.3064586	0.1514231	-2.023857	0.0429849	0.0525149	0.0429849	0.0425914	7.360490e-01	0.5470351	9.903718e-01	Aldoc	up
69	RAPGEF5	RAPGEF5	0.3193432	0.1604457	1.990350	0.0465524	0.0524216	0.0465524	0.0445547	1.376224e+00	1.0048872	1.884780e+00	Rapgef5	up
43	LDB3	LDB3	0.3834987	0.1921256	1.996083	0.0459248	0.0536589	0.0459248	0.0447002	1.467410e+00	1.0069636	2.138400e+00	Ldb3	up
33	GDF10	GDF10	-0.2476631	0.1253271	-1.976134	0.0481396	0.0394339	0.0481396	0.0457862	7.806229e-01	0.6106083	9.979755e-01	Gdf10	up
84	TPPP	TPPP	0.2895090	0.1455712	1.988779	0.0467256	0.0504267	0.0467256	0.0459345	1.335771e+00	1.0042035	1.776817e+00	Tppp	up
66	PPIL6	PPIL6	-0.8324625	0.4144059	-2.008809	0.0445573	0.0400225	0.0445573	0.0463260	4.349768e-01	0.1930737	9.799617e-01	Ppil6	up
23	CNTNAP4	CNTNAP4	0.4244264	0.2146225	1.977548	0.0479797	0.0526664	0.0479797	0.0466958	1.528713e+00	1.0037811	2.328161e+00	Cntnap4	up
31	FRY	FRY	-0.6944304	0.3511521	-1.977577	0.0479764	0.0486039	0.0479764	0.0472073	4.993588e-01	0.2509062	9.938342e-01	Fry	up
41	IRX2	IRX2	-0.3255989	0.1648842	-1.974713	0.0483007	0.0587783	0.0483007	0.0477633	7.220948e-01	0.5226904	9.975711e-01	Irx2	down
11	CARTPT	CARTPT	0.1630698	0.0843582	1.933065	0.0532282	0.0819939	0.0532282	0.0496218	1.177119e+00	0.9977334	1.388756e+00	Cartpt	up
83	TMCO5A	TMCO5A	82.6409564	43.6960941	1.891266	0.0585888	0.1037047	0.0585888	0.0498658	7.771616e+35	0.0496968	1.215330e+73	Tmco5	up

only GBM

Gene-sets considered

UP and DOWN

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Table genes

	Variable	Term	Beta	StandardError	Z	P	LRT	Wald	LogRank	HR	HRlower	HRupper	mm	status
36	GPR139	GPR139	5.1595162	1.0707833	4.818450	0.0000014	0.0000396	0.0000014	0.0000000	1.740802e+02	21.3450416	1.419717e+03	Gpr139	up
61	PCDHGA3	PCDHGA3	0.7508024	0.2053482	3.656241	0.0002559	0.0025701	0.0002559	0.0000236	2.118699e+00	1.4166959	3.168560e+00	Pcdhga3	up
18	CHIC2	CHIC2	1.3148603	0.3211465	4.094269	0.0000424	0.0002660	0.0000424	0.0000446	3.724231e+00	1.9846144	6.988710e+00	Chic2	down
63	PHKG1	PHKG1	-0.6406674	0.1684263	-3.803845	0.0001425	0.0002338	0.0001425	0.0001123	5.269406e-01	0.3787887	7.330378e-01	Phkg1	up
3	ADAMTS3	ADAMTS3	3.2224925	1.0514520	3.064802	0.0021781	0.0093278	0.0021781	0.0001595	2.509058e+01	3.1953107	1.970191e+02	Adamts3	up
21	CLEC18A	CLEC18A	2.8000255	0.7790372	3.594213	0.0003254	0.0014044	0.0003254	0.0001713	1.644507e+01	3.5720534	7.571001e+01	Clec18a	up
46	LIX1	LIX1	-0.6899061	0.1972237	-3.498089	0.0004686	0.0005864	0.0004686	0.0003863	5.016232e-01	0.3408007	7.383372e-01	Lix1	up
72	SFTPC	SFTPC	0.7150386	0.2109331	3.389884	0.0006992	0.0007212	0.0006992	0.0005360	2.044266e+00	1.3520438	3.090892e+00	Sftpc	up
62	PCDHGA8	PCDHGA8	5.2362662	1.6538533	3.166101	0.0015450	0.0096278	0.0015450	0.0011135	1.879670e+02	7.3505362	4.806666e+03	Pcdhga8	up
93	ZBTB8B	ZBTB8B	1.1365043	0.3520922	3.227860	0.0012472	0.0015945	0.0012472	0.0011193	3.115857e+00	1.5627018	6.212679e+00	Zbtb8b	up
48	LRRK2	LRRK2	0.5470006	0.1760081	3.107815	0.0018848	0.0038480	0.0018848	0.0016209	1.728062e+00	1.2238861	2.439932e+00	Lrrk2	up
73	SH3GL2	SH3GL2	-0.7681192	0.2405062	-3.193760	0.0014043	0.0017402	0.0014043	0.0017373	4.638847e-01	0.2895282	7.432404e-01	Sh3gl2	up
56	MYH1	MYH1	6.4885350	2.3189710	2.798023	0.0051416	0.0245868	0.0051416	0.0019006	6.575594e+02	6.9826986	6.192224e+04	Myh1	up
10	BVES	BVES	0.6492014	0.2109948	3.076860	0.0020919	0.0034852	0.0020919	0.0022376	1.914012e+00	1.2657428	2.894301e+00	Bves	up
30	FAM186B	FAM186B	3.6808737	1.2262259	3.001791	0.0026840	0.0048851	0.0026840	0.0028607	3.968105e+01	3.5877136	4.388828e+02	Fam186b	up
77	SMIM1	SMIM1	0.8812849	0.3007913	2.929889	0.0033908	0.0049659	0.0033908	0.0032167	2.414000e+00	1.3387614	4.352825e+00	Smim1	up
4	AHCYL2	AHCYL2	-0.6577339	0.2262623	-2.906954	0.0036497	0.0028521	0.0036497	0.0033225	5.180239e-01	0.3324719	8.071320e-01	Ahcyl2	up
35	GLT8D2	GLT8D2	-2.1935510	0.7573641	-2.896297	0.0037760	0.0018451	0.0037760	0.0034438	1.115200e-01	0.0252746	4.920649e-01	Glt8d2	up
16	CEP135	CEP135	0.9612037	0.3279532	2.930917	0.0033796	0.0113210	0.0033796	0.0035540	2.614842e+00	1.3749635	4.972786e+00	Cep135	down
64	PLCXD1	PLCXD1	0.7187168	0.2420552	2.969226	0.0029855	0.0042069	0.0029855	0.0038072	2.051799e+00	1.2767238	3.297407e+00	Plcxd1	up
1	ABCA8	ABCA8	0.4570804	0.1554996	2.939431	0.0032882	0.0086596	0.0032882	0.0038081	1.579456e+00	1.1645174	2.142244e+00	Abca8b	up
38	HHATL	HHATL	0.3972220	0.1379059	2.880384	0.0039719	0.0037733	0.0039719	0.0039397	1.487686e+00	1.1353391	1.949383e+00	Hhatl	up
19	CHRM5	CHRM5	1.9356194	0.6916367	2.798607	0.0051324	0.0113490	0.0051324	0.0039951	6.928334e+00	1.7861035	2.687516e+01	Chrm5	up
8	BARX2	BARX2	4.2196030	1.5075048	2.799064	0.0051251	0.0101462	0.0051251	0.0043039	6.800648e+01	3.5429083	1.305391e+03	Barx2	up
52	METTL11B	METTL11B	2.5058448	0.9684965	2.587356	0.0096716	0.0338070	0.0096716	0.0050058	1.225391e+01	1.8360684	8.178248e+01	Mettl11b	up
13	CCDC87	CCDC87	-0.6405216	0.2300130	-2.784719	0.0053574	0.0053539	0.0053574	0.0051444	5.270174e-01	0.3357666	8.272036e-01	Ccdc87	up
44	LGI3	LGI3	0.3468954	0.1262967	2.746671	0.0060204	0.0058834	0.0060204	0.0056087	1.414669e+00	1.1044621	1.812002e+00	Lgi3	up
90	TUB	TUB	-0.5353015	0.1944482	-2.752925	0.0059065	0.0069206	0.0059065	0.0057163	5.854927e-01	0.3999511	8.571092e-01	Tub	up
74	SLC35F4	SLC35F4	7.7687589	3.3957542	2.287786	0.0221500	0.0864739	0.0221500	0.0063834	2.365534e+03	3.0440926	1.838232e+06	Slc35f4	up
85	TPSAB1	TPSAB1	-0.8846744	0.3542311	-2.497450	0.0125090	0.0006903	0.0125090	0.0063899	4.128486e-01	0.2061905	8.266333e-01	Tpsb2	down
39	HHIP	HHIP	0.5059547	0.1893155	2.672548	0.0075278	0.0125895	0.0075278	0.0067012	1.658568e+00	1.1444259	2.403693e+00	Hhip	up
25	CRTAC1	CRTAC1	-0.5325153	0.2040986	-2.609107	0.0090779	0.0096375	0.0090779	0.0088457	5.871263e-01	0.3935523	8.759123e-01	Crtac1	up
32	FXYD7	FXYD7	0.2876284	0.1121605	2.564436	0.0103343	0.0106282	0.0103343	0.0093643	1.333262e+00	1.0701490	1.661065e+00	Fxyd7	up
6	AOX3P	AOX3P	11.3330802	4.4432645	2.550620	0.0107531	0.0331895	0.0107531	0.0097299	8.353995e+04	13.7968724	5.058337e+08	Aox3	up
76	SLCO4A1	SLCO4A1	0.5349134	0.2092046	2.556891	0.0105612	0.0149816	0.0105612	0.0103656	1.707300e+00	1.1330123	2.572677e+00	Slco4a1	up
91	VWC2	VWC2	-0.8658511	0.3444749	-2.513539	0.0119527	0.0076251	0.0119527	0.0104954	4.206934e-01	0.2141648	8.263865e-01	Vwc2	up
34	GLRA3	GLRA3	-0.7538191	0.3011341	-2.503267	0.0123053	0.0079996	0.0123053	0.0114512	4.705660e-01	0.2607922	8.490756e-01	Glra3	up
75	SLC8A3	SLC8A3	-0.6592973	0.2645167	-2.492460	0.0126862	0.0094084	0.0126862	0.0114866	5.172147e-01	0.3079738	8.686161e-01	Slc8a3	up
65	POPDC3	POPDC3	0.4728442	0.1902276	2.485676	0.0129306	0.0187433	0.0129306	0.0117812	1.604551e+00	1.1051763	2.329569e+00	Popdc3	up
86	TPSB2	TPSB2	-0.8013200	0.3290348	-2.435365	0.0148768	0.0022816	0.0148768	0.0118109	4.487363e-01	0.2354595	8.551968e-01	Tpsb2	down
58	NLRP6	NLRP6	0.6709421	0.2702415	2.482750	0.0130373	0.0218135	0.0130373	0.0125357	1.956079e+00	1.1517453	3.322128e+00	Nlrp6	up
60	PCDH7	PCDH7	-0.6628942	0.2660821	-2.491314	0.0127271	0.0104717	0.0127271	0.0125628	5.153577e-01	0.3059280	8.681569e-01	Pcdh7	up
24	CPA3	CPA3	-3.5762611	1.9488975	-1.835017	0.0665031	0.0007919	0.0665031	0.0136850	2.798010e-02	0.0006137	1.275716e+00	Cpa3	down
15	CDH7	CDH7	-0.8340137	0.3472870	-2.401512	0.0163275	0.0091114	0.0163275	0.0140317	4.343026e-01	0.2198777	8.578348e-01	Cdh7	up
2	ABLIM3	ABLIM3	-0.4808436	0.1974873	-2.434808	0.0148997	0.0152889	0.0148997	0.0144433	6.182616e-01	0.4198275	9.104870e-01	Ablim3	up
9	BMP3	BMP3	1.3553265	0.5709786	2.373690	0.0176113	0.0373274	0.0176113	0.0148387	3.878027e+00	1.2664643	1.187487e+01	Bmp3	up
45	LIPG	LIPG	-0.5180286	0.2142283	-2.418115	0.0156012	0.0156964	0.0156012	0.0151243	5.956937e-01	0.3914458	9.065139e-01	Lipg	up
20	CHST15	CHST15	-0.5033978	0.2093893	-2.404124	0.0162113	0.0171423	0.0162113	0.0158504	6.044733e-01	0.4010002	9.111914e-01	Chst15	up
50	MAP6D1	MAP6D1	0.3774339	0.1582533	2.384999	0.0170792	0.0189951	0.0170792	0.0161717	1.458537e+00	1.0695770	1.988946e+00	Map6d1	up
67	PPP2R2B	PPP2R2B	-0.8738006	0.3636238	-2.403035	0.0162596	0.0143470	0.0162596	0.0162598	4.173623e-01	0.2046426	8.511975e-01	Ppp2r2b	up
53	MGAT4C	MGAT4C	-1.3967395	0.5768181	-2.421456	0.0154585	0.0077684	0.0154585	0.0173673	2.474023e-01	0.0798758	7.662883e-01	Mgat4c	up
49	LUZP2	LUZP2	-0.5286152	0.2259100	-2.339937	0.0192870	0.0215066	0.0192870	0.0185859	5.894206e-01	0.3785562	9.177414e-01	Luzp2	up
22	CLMN	CLMN	0.6592381	0.2808949	2.346921	0.0189293	0.0300935	0.0189293	0.0196584	1.933319e+00	1.1148214	3.352753e+00	Clmn	up
79	SPOCK3	SPOCK3	0.5432691	0.2349925	2.311857	0.0207855	0.0283806	0.0207855	0.0197538	1.721626e+00	1.0862075	2.728756e+00	Spock3	up
70	RNF32	RNF32	-0.8573740	0.3707326	-2.312648	0.0207420	0.0208589	0.0207420	0.0203103	4.242748e-01	0.2051536	8.774358e-01	Rnf32	up
59	NSUN7	NSUN7	3.4739776	1.5269652	2.275086	0.0229008	0.0292430	0.0229008	0.0214978	3.226482e+01	1.6179837	6.434050e+02	Nsun7	up
89	TTLL7	TTLL7	0.5323731	0.2360615	2.255231	0.0241189	0.0273676	0.0241189	0.0242335	1.702969e+00	1.0721876	2.704847e+00	Ttll7	up
7	ARHGAP8	ARHGAP8	20.8761762	9.4024620	2.220288	0.0263992	0.0399771	0.0263992	0.0246239	1.165220e+09	11.5616004	1.174352e+17	Arhgap8	down
82	TGM3	TGM3	-4.2363329	1.9422468	-2.181151	0.0291723	0.0073239	0.0291723	0.0251856	1.446050e-02	0.0003213	6.507699e-01	Tgm3	up
71	SERINC2	SERINC2	0.4735774	0.2137832	2.215223	0.0267448	0.0318912	0.0267448	0.0261266	1.605728e+00	1.0560865	2.441432e+00	Serinc2	up
55	MUSK	MUSK	14.1949811	6.5867212	2.155091	0.0311547	0.0678555	0.0311547	0.0279285	1.461511e+06	3.6155532	5.907847e+11	Musk	up
12	CCDC74B	CCDC74B	-0.5455931	0.2493796	-2.187802	0.0286840	0.0294507	0.0286840	0.0283321	5.794980e-01	0.3554509	9.447659e-01	Ccdc74a	up
42	KCNG1	KCNG1	-0.4093191	0.1876366	-2.181446	0.0291504	0.0208728	0.0291504	0.0291734	6.641023e-01	0.4597465	9.592936e-01	Kcng1	up
28	FAM110B	FAM110B	-0.4469752	0.2066142	-2.163333	0.0305156	0.0322178	0.0305156	0.0297200	6.395597e-01	0.4265901	9.588517e-01	Fam110b	up
68	PRSS35	PRSS35	-0.2598632	0.1208744	-2.149861	0.0315662	0.0362531	0.0315662	0.0299232	7.711571e-01	0.6084913	9.773077e-01	Prss35	up
27	EFCAB6	EFCAB6	-4.6697434	2.1733079	-2.148680	0.0316598	0.0230073	0.0316598	0.0302239	9.374700e-03	0.0001324	6.635586e-01	Efcab6	up
40	INHBA	INHBA	-0.7294275	0.3291556	-2.216057	0.0266876	0.0184006	0.0266876	0.0302935	4.821850e-01	0.2529507	9.191606e-01	Inhba	up
80	SYT17	SYT17	-0.7200108	0.3371428	-2.135626	0.0327099	0.0303318	0.0327099	0.0319226	4.867470e-01	0.2513778	9.424965e-01	Syt17	up
26	CRYBB1	CRYBB1	-0.6315141	0.2924614	-2.159307	0.0308263	0.0275145	0.0308263	0.0323952	5.317860e-01	0.2997735	9.433667e-01	Crybb1	up
51	MEIG1	MEIG1	-1.5568552	0.7345368	-2.119506	0.0340477	0.0203682	0.0340477	0.0328155	2.107979e-01	0.0499606	8.894166e-01	Meig1	up
87	TRPC1	TRPC1	-0.9133696	0.4337654	-2.105676	0.0352325	0.0361240	0.0352325	0.0336084	4.011702e-01	0.1714379	9.387510e-01	Trpc1	up
88	TTLL11	TTLL11	1.6033388	0.7533240	2.128352	0.0333079	0.0457185	0.0333079	0.0338183	4.969597e+00	1.1352478	2.175463e+01	Ttll11	up
37	GRIA3	GRIA3	-0.5537059	0.2629723	-2.105567	0.0352420	0.0362229	0.0352420	0.0339876	5.748157e-01	0.3433098	9.624341e-01	Gria3	up
78	SPHKAP	SPHKAP	-0.3948747	0.1885112	-2.094701	0.0361976	0.0354954	0.0361976	0.0350410	6.737645e-01	0.4656365	9.749204e-01	Sphkap	up
17	CES1	CES1	-1.2365117	0.6037801	-2.047950	0.0405649	0.0117912	0.0405649	0.0353114	2.903954e-01	0.0889306	9.482620e-01	Ces1d	up
92	WNT4	WNT4	-0.8323685	0.4111895	-2.024294	0.0429399	0.0156938	0.0429399	0.0364697	4.350177e-01	0.1943130	9.738950e-01	Wnt4	up
29	FAM135B	FAM135B	-1.1288911	0.5417063	-2.083954	0.0371643	0.0296138	0.0371643	0.0366978	3.233917e-01	0.1118478	9.350398e-01	Fam135b	up
57	NIPAL3	NIPAL3	0.3346470	0.1612557	2.075257	0.0379627	0.0390300	0.0379627	0.0369967	1.397447e+00	1.0187656	1.916887e+00	Nipal3	up
14	CCL27	CCL27	-8.0296337	4.5567387	-1.762145	0.0780448	0.0069579	0.0780448	0.0373252	3.257000e-04	0.0000000	2.463074e+00	Ccl27a	up
54	MT3	MT3	0.3041427	0.1425664	2.133341	0.0328967	0.0234258	0.0328967	0.0395999	1.355462e+00	1.0250258	1.792422e+00	Mt3	up
47	LRRC6	LRRC6	-1.0838316	0.5327818	-2.034288	0.0419226	0.0388757	0.0419226	0.0396194	3.382968e-01	0.1190675	9.611754e-01	Lrrc6	up
81	TENM4	TENM4	-0.6701993	0.3295016	-2.033979	0.0419538	0.0392560	0.0419538	0.0413113	5.116066e-01	0.2682031	9.759070e-01	Tenm4	up
5	ALDOC	ALDOC	-0.3064586	0.1514231	-2.023857	0.0429849	0.0525149	0.0429849	0.0425914	7.360490e-01	0.5470351	9.903718e-01	Aldoc	up
69	RAPGEF5	RAPGEF5	0.3193432	0.1604457	1.990350	0.0465524	0.0524216	0.0465524	0.0445547	1.376224e+00	1.0048872	1.884780e+00	Rapgef5	up
43	LDB3	LDB3	0.3834987	0.1921256	1.996083	0.0459248	0.0536589	0.0459248	0.0447002	1.467410e+00	1.0069636	2.138400e+00	Ldb3	up
33	GDF10	GDF10	-0.2476631	0.1253271	-1.976134	0.0481396	0.0394339	0.0481396	0.0457862	7.806229e-01	0.6106083	9.979755e-01	Gdf10	up
84	TPPP	TPPP	0.2895090	0.1455712	1.988779	0.0467256	0.0504267	0.0467256	0.0459345	1.335771e+00	1.0042035	1.776817e+00	Tppp	up
66	PPIL6	PPIL6	-0.8324625	0.4144059	-2.008809	0.0445573	0.0400225	0.0445573	0.0463260	4.349768e-01	0.1930737	9.799617e-01	Ppil6	up
23	CNTNAP4	CNTNAP4	0.4244264	0.2146225	1.977548	0.0479797	0.0526664	0.0479797	0.0466958	1.528713e+00	1.0037811	2.328161e+00	Cntnap4	up
31	FRY	FRY	-0.6944304	0.3511521	-1.977577	0.0479764	0.0486039	0.0479764	0.0472073	4.993588e-01	0.2509062	9.938342e-01	Fry	up
41	IRX2	IRX2	-0.3255989	0.1648842	-1.974713	0.0483007	0.0587783	0.0483007	0.0477633	7.220948e-01	0.5226904	9.975711e-01	Irx2	down
11	CARTPT	CARTPT	0.1630698	0.0843582	1.933065	0.0532282	0.0819939	0.0532282	0.0496218	1.177119e+00	0.9977334	1.388756e+00	Cartpt	up
83	TMCO5A	TMCO5A	82.6409564	43.6960941	1.891266	0.0585888	0.1037047	0.0585888	0.0498658	7.771616e+35	0.0496968	1.215330e+73	Tmco5	up