Result

Analysis details

Demographic information

load("/mnt/data/lab/gmt_data/data_brain/gmt_analysis/compare_mouse_signatures_with_human/annotation_gbm_lgg_July2021.RData")
colnames(ann3)[1]<-"Samples"

annotation_mut<-ann3[ann3$type%in%"LGG" & (ann3$IDH1==1 | ann3$IDH2==1)  & (ann3$TP53==1 & ann3$ATRX==1),]
print(paste("The number of samples LGG with IDH*, TP53, ATRX is:",nrow(annotation_mut)))
## [1] "The number of samples LGG with IDH*, TP53, ATRX is: 164"
annotation_only_idh<-ann3[ann3$type%in%"LGG" & (ann3$IDH1==1 | ann3$IDH2==1),]
print(paste("The number of samples LGG with IDH* is:",nrow(annotation_only_idh)))
## [1] "The number of samples LGG with IDH* is: 411"
annotation_gbm_lgg<-ann3
print(paste("The number of samples LGG  and GBM:",nrow(annotation_gbm_lgg)))
## [1] "The number of samples LGG  and GBM: 794"
annotation_idh_codel_nocodel<-ann3[ann3$type%in%"LGG" & (ann3$IDH_codel_subtype=="IDHmut-codel" | ann3$IDH_codel_subtype=="IDHmut-non-codel"),]
print(paste("The number of samples LGG IDHmut-codel and IDHmut-non-codel is:",nrow(annotation_idh_codel_nocodel)))
## [1] "The number of samples LGG IDHmut-codel and IDHmut-non-codel is: 414"
annotation_idh_codel<-ann3[ann3$type%in%"LGG" & (ann3$IDH_codel_subtype=="IDHmut-codel"),]
print(paste("The number of samples LGG with IDHmut-codel is:",nrow(annotation_idh_codel)))
## [1] "The number of samples LGG with IDHmut-codel is: 169"
annotation_idh_nocodel<-ann3[ann3$type%in%"LGG" & (ann3$IDH_codel_subtype=="IDHmut-non-codel"),]
print(paste("The number of samples LGG with IDHmut-non-codel is:",nrow(annotation_idh_nocodel)))
## [1] "The number of samples LGG with IDHmut-non-codel is: 245"
annotation_gbm_only<-ann3[ann3$type%in%"GBM",]
print(paste("The number of samples GBM is:",nrow(annotation_gbm_only)))
## [1] "The number of samples GBM is: 285"

Analysis

  • Step1: Select the genes with cox proportional hazard models in IDH*/TP53/IATRX samples (logRank p-value < 0.05)
  • Step2: Select a group of samples (e.g. IDH*/TP53/ATRX)
  • Step3: Consider different tresholds of logRank 0.01,0.001,0.05
  • Step4: Select the genes according with Step3
  • Step5: Compute the gsva scores (default parameters) using 1) up and down genes 2) only up 3) only down
  • Step6: If there is a sufficent number of genes, compute the difference between the scores computed using the up-regulated genes and down-regulated genes (up-down) (C1A is the numerator). This whati I call “global_score”.
  • Step7: The stratification of the samples is perfomed using 0 as cut-off value to distinguish (MCP). The classification are stored in a column (“status_C1AC1B”).
  • Step8: Plot the Kaplan Meier curve with the overall survival as outcome
  • Step9: Use surv_cutpoint and column global_score to define automatically a cut-point for the groups

FAQ report

  • The order of the rows is based on the logRank cut-off (0.05, 0.01, 0.01)
  • First column: overall survival using manual cut-point (0) see Step7
  • Second-third columns: results surv_cutpoint
  • Second-third columns: results surv_cutpoint
  • Table-genes: results of cox proportional hazard model with IDH*/TP53/IATRX samples (logRank p-value < 0.05). Use column logRank to select the genes.

IDH TRIPLE MUT

UP and DOWN

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UP

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DOWN

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Table genes

Variable Term Beta StandardError Z P LRT Wald LogRank HR HRlower HRupper mm status
36 GPR139 GPR139 5.1595162 1.0707833 4.818450 0.0000014 0.0000396 0.0000014 0.0000000 1.740802e+02 21.3450416 1.419717e+03 Gpr139 up
61 PCDHGA3 PCDHGA3 0.7508024 0.2053482 3.656241 0.0002559 0.0025701 0.0002559 0.0000236 2.118699e+00 1.4166959 3.168560e+00 Pcdhga3 up
18 CHIC2 CHIC2 1.3148603 0.3211465 4.094269 0.0000424 0.0002660 0.0000424 0.0000446 3.724231e+00 1.9846144 6.988710e+00 Chic2 down
63 PHKG1 PHKG1 -0.6406674 0.1684263 -3.803845 0.0001425 0.0002338 0.0001425 0.0001123 5.269406e-01 0.3787887 7.330378e-01 Phkg1 up
3 ADAMTS3 ADAMTS3 3.2224925 1.0514520 3.064802 0.0021781 0.0093278 0.0021781 0.0001595 2.509058e+01 3.1953107 1.970191e+02 Adamts3 up
21 CLEC18A CLEC18A 2.8000255 0.7790372 3.594213 0.0003254 0.0014044 0.0003254 0.0001713 1.644507e+01 3.5720534 7.571001e+01 Clec18a up
46 LIX1 LIX1 -0.6899061 0.1972237 -3.498089 0.0004686 0.0005864 0.0004686 0.0003863 5.016232e-01 0.3408007 7.383372e-01 Lix1 up
72 SFTPC SFTPC 0.7150386 0.2109331 3.389884 0.0006992 0.0007212 0.0006992 0.0005360 2.044266e+00 1.3520438 3.090892e+00 Sftpc up
62 PCDHGA8 PCDHGA8 5.2362662 1.6538533 3.166101 0.0015450 0.0096278 0.0015450 0.0011135 1.879670e+02 7.3505362 4.806666e+03 Pcdhga8 up
93 ZBTB8B ZBTB8B 1.1365043 0.3520922 3.227860 0.0012472 0.0015945 0.0012472 0.0011193 3.115857e+00 1.5627018 6.212679e+00 Zbtb8b up
48 LRRK2 LRRK2 0.5470006 0.1760081 3.107815 0.0018848 0.0038480 0.0018848 0.0016209 1.728062e+00 1.2238861 2.439932e+00 Lrrk2 up
73 SH3GL2 SH3GL2 -0.7681192 0.2405062 -3.193760 0.0014043 0.0017402 0.0014043 0.0017373 4.638847e-01 0.2895282 7.432404e-01 Sh3gl2 up
56 MYH1 MYH1 6.4885350 2.3189710 2.798023 0.0051416 0.0245868 0.0051416 0.0019006 6.575594e+02 6.9826986 6.192224e+04 Myh1 up
10 BVES BVES 0.6492014 0.2109948 3.076860 0.0020919 0.0034852 0.0020919 0.0022376 1.914012e+00 1.2657428 2.894301e+00 Bves up
30 FAM186B FAM186B 3.6808737 1.2262259 3.001791 0.0026840 0.0048851 0.0026840 0.0028607 3.968105e+01 3.5877136 4.388828e+02 Fam186b up
77 SMIM1 SMIM1 0.8812849 0.3007913 2.929889 0.0033908 0.0049659 0.0033908 0.0032167 2.414000e+00 1.3387614 4.352825e+00 Smim1 up
4 AHCYL2 AHCYL2 -0.6577339 0.2262623 -2.906954 0.0036497 0.0028521 0.0036497 0.0033225 5.180239e-01 0.3324719 8.071320e-01 Ahcyl2 up
35 GLT8D2 GLT8D2 -2.1935510 0.7573641 -2.896297 0.0037760 0.0018451 0.0037760 0.0034438 1.115200e-01 0.0252746 4.920649e-01 Glt8d2 up
16 CEP135 CEP135 0.9612037 0.3279532 2.930917 0.0033796 0.0113210 0.0033796 0.0035540 2.614842e+00 1.3749635 4.972786e+00 Cep135 down
64 PLCXD1 PLCXD1 0.7187168 0.2420552 2.969226 0.0029855 0.0042069 0.0029855 0.0038072 2.051799e+00 1.2767238 3.297407e+00 Plcxd1 up
1 ABCA8 ABCA8 0.4570804 0.1554996 2.939431 0.0032882 0.0086596 0.0032882 0.0038081 1.579456e+00 1.1645174 2.142244e+00 Abca8b up
38 HHATL HHATL 0.3972220 0.1379059 2.880384 0.0039719 0.0037733 0.0039719 0.0039397 1.487686e+00 1.1353391 1.949383e+00 Hhatl up
19 CHRM5 CHRM5 1.9356194 0.6916367 2.798607 0.0051324 0.0113490 0.0051324 0.0039951 6.928334e+00 1.7861035 2.687516e+01 Chrm5 up
8 BARX2 BARX2 4.2196030 1.5075048 2.799064 0.0051251 0.0101462 0.0051251 0.0043039 6.800648e+01 3.5429083 1.305391e+03 Barx2 up
52 METTL11B METTL11B 2.5058448 0.9684965 2.587356 0.0096716 0.0338070 0.0096716 0.0050058 1.225391e+01 1.8360684 8.178248e+01 Mettl11b up
13 CCDC87 CCDC87 -0.6405216 0.2300130 -2.784719 0.0053574 0.0053539 0.0053574 0.0051444 5.270174e-01 0.3357666 8.272036e-01 Ccdc87 up
44 LGI3 LGI3 0.3468954 0.1262967 2.746671 0.0060204 0.0058834 0.0060204 0.0056087 1.414669e+00 1.1044621 1.812002e+00 Lgi3 up
90 TUB TUB -0.5353015 0.1944482 -2.752925 0.0059065 0.0069206 0.0059065 0.0057163 5.854927e-01 0.3999511 8.571092e-01 Tub up
74 SLC35F4 SLC35F4 7.7687589 3.3957542 2.287786 0.0221500 0.0864739 0.0221500 0.0063834 2.365534e+03 3.0440926 1.838232e+06 Slc35f4 up
85 TPSAB1 TPSAB1 -0.8846744 0.3542311 -2.497450 0.0125090 0.0006903 0.0125090 0.0063899 4.128486e-01 0.2061905 8.266333e-01 Tpsb2 down
39 HHIP HHIP 0.5059547 0.1893155 2.672548 0.0075278 0.0125895 0.0075278 0.0067012 1.658568e+00 1.1444259 2.403693e+00 Hhip up
25 CRTAC1 CRTAC1 -0.5325153 0.2040986 -2.609107 0.0090779 0.0096375 0.0090779 0.0088457 5.871263e-01 0.3935523 8.759123e-01 Crtac1 up
32 FXYD7 FXYD7 0.2876284 0.1121605 2.564436 0.0103343 0.0106282 0.0103343 0.0093643 1.333262e+00 1.0701490 1.661065e+00 Fxyd7 up
6 AOX3P AOX3P 11.3330802 4.4432645 2.550620 0.0107531 0.0331895 0.0107531 0.0097299 8.353995e+04 13.7968724 5.058337e+08 Aox3 up
76 SLCO4A1 SLCO4A1 0.5349134 0.2092046 2.556891 0.0105612 0.0149816 0.0105612 0.0103656 1.707300e+00 1.1330123 2.572677e+00 Slco4a1 up
91 VWC2 VWC2 -0.8658511 0.3444749 -2.513539 0.0119527 0.0076251 0.0119527 0.0104954 4.206934e-01 0.2141648 8.263865e-01 Vwc2 up
34 GLRA3 GLRA3 -0.7538191 0.3011341 -2.503267 0.0123053 0.0079996 0.0123053 0.0114512 4.705660e-01 0.2607922 8.490756e-01 Glra3 up
75 SLC8A3 SLC8A3 -0.6592973 0.2645167 -2.492460 0.0126862 0.0094084 0.0126862 0.0114866 5.172147e-01 0.3079738 8.686161e-01 Slc8a3 up
65 POPDC3 POPDC3 0.4728442 0.1902276 2.485676 0.0129306 0.0187433 0.0129306 0.0117812 1.604551e+00 1.1051763 2.329569e+00 Popdc3 up
86 TPSB2 TPSB2 -0.8013200 0.3290348 -2.435365 0.0148768 0.0022816 0.0148768 0.0118109 4.487363e-01 0.2354595 8.551968e-01 Tpsb2 down
58 NLRP6 NLRP6 0.6709421 0.2702415 2.482750 0.0130373 0.0218135 0.0130373 0.0125357 1.956079e+00 1.1517453 3.322128e+00 Nlrp6 up
60 PCDH7 PCDH7 -0.6628942 0.2660821 -2.491314 0.0127271 0.0104717 0.0127271 0.0125628 5.153577e-01 0.3059280 8.681569e-01 Pcdh7 up
24 CPA3 CPA3 -3.5762611 1.9488975 -1.835017 0.0665031 0.0007919 0.0665031 0.0136850 2.798010e-02 0.0006137 1.275716e+00 Cpa3 down
15 CDH7 CDH7 -0.8340137 0.3472870 -2.401512 0.0163275 0.0091114 0.0163275 0.0140317 4.343026e-01 0.2198777 8.578348e-01 Cdh7 up
2 ABLIM3 ABLIM3 -0.4808436 0.1974873 -2.434808 0.0148997 0.0152889 0.0148997 0.0144433 6.182616e-01 0.4198275 9.104870e-01 Ablim3 up
9 BMP3 BMP3 1.3553265 0.5709786 2.373690 0.0176113 0.0373274 0.0176113 0.0148387 3.878027e+00 1.2664643 1.187487e+01 Bmp3 up
45 LIPG LIPG -0.5180286 0.2142283 -2.418115 0.0156012 0.0156964 0.0156012 0.0151243 5.956937e-01 0.3914458 9.065139e-01 Lipg up
20 CHST15 CHST15 -0.5033978 0.2093893 -2.404124 0.0162113 0.0171423 0.0162113 0.0158504 6.044733e-01 0.4010002 9.111914e-01 Chst15 up
50 MAP6D1 MAP6D1 0.3774339 0.1582533 2.384999 0.0170792 0.0189951 0.0170792 0.0161717 1.458537e+00 1.0695770 1.988946e+00 Map6d1 up
67 PPP2R2B PPP2R2B -0.8738006 0.3636238 -2.403035 0.0162596 0.0143470 0.0162596 0.0162598 4.173623e-01 0.2046426 8.511975e-01 Ppp2r2b up
53 MGAT4C MGAT4C -1.3967395 0.5768181 -2.421456 0.0154585 0.0077684 0.0154585 0.0173673 2.474023e-01 0.0798758 7.662883e-01 Mgat4c up
49 LUZP2 LUZP2 -0.5286152 0.2259100 -2.339937 0.0192870 0.0215066 0.0192870 0.0185859 5.894206e-01 0.3785562 9.177414e-01 Luzp2 up
22 CLMN CLMN 0.6592381 0.2808949 2.346921 0.0189293 0.0300935 0.0189293 0.0196584 1.933319e+00 1.1148214 3.352753e+00 Clmn up
79 SPOCK3 SPOCK3 0.5432691 0.2349925 2.311857 0.0207855 0.0283806 0.0207855 0.0197538 1.721626e+00 1.0862075 2.728756e+00 Spock3 up
70 RNF32 RNF32 -0.8573740 0.3707326 -2.312648 0.0207420 0.0208589 0.0207420 0.0203103 4.242748e-01 0.2051536 8.774358e-01 Rnf32 up
59 NSUN7 NSUN7 3.4739776 1.5269652 2.275086 0.0229008 0.0292430 0.0229008 0.0214978 3.226482e+01 1.6179837 6.434050e+02 Nsun7 up
89 TTLL7 TTLL7 0.5323731 0.2360615 2.255231 0.0241189 0.0273676 0.0241189 0.0242335 1.702969e+00 1.0721876 2.704847e+00 Ttll7 up
7 ARHGAP8 ARHGAP8 20.8761762 9.4024620 2.220288 0.0263992 0.0399771 0.0263992 0.0246239 1.165220e+09 11.5616004 1.174352e+17 Arhgap8 down
82 TGM3 TGM3 -4.2363329 1.9422468 -2.181151 0.0291723 0.0073239 0.0291723 0.0251856 1.446050e-02 0.0003213 6.507699e-01 Tgm3 up
71 SERINC2 SERINC2 0.4735774 0.2137832 2.215223 0.0267448 0.0318912 0.0267448 0.0261266 1.605728e+00 1.0560865 2.441432e+00 Serinc2 up
55 MUSK MUSK 14.1949811 6.5867212 2.155091 0.0311547 0.0678555 0.0311547 0.0279285 1.461511e+06 3.6155532 5.907847e+11 Musk up
12 CCDC74B CCDC74B -0.5455931 0.2493796 -2.187802 0.0286840 0.0294507 0.0286840 0.0283321 5.794980e-01 0.3554509 9.447659e-01 Ccdc74a up
42 KCNG1 KCNG1 -0.4093191 0.1876366 -2.181446 0.0291504 0.0208728 0.0291504 0.0291734 6.641023e-01 0.4597465 9.592936e-01 Kcng1 up
28 FAM110B FAM110B -0.4469752 0.2066142 -2.163333 0.0305156 0.0322178 0.0305156 0.0297200 6.395597e-01 0.4265901 9.588517e-01 Fam110b up
68 PRSS35 PRSS35 -0.2598632 0.1208744 -2.149861 0.0315662 0.0362531 0.0315662 0.0299232 7.711571e-01 0.6084913 9.773077e-01 Prss35 up
27 EFCAB6 EFCAB6 -4.6697434 2.1733079 -2.148680 0.0316598 0.0230073 0.0316598 0.0302239 9.374700e-03 0.0001324 6.635586e-01 Efcab6 up
40 INHBA INHBA -0.7294275 0.3291556 -2.216057 0.0266876 0.0184006 0.0266876 0.0302935 4.821850e-01 0.2529507 9.191606e-01 Inhba up
80 SYT17 SYT17 -0.7200108 0.3371428 -2.135626 0.0327099 0.0303318 0.0327099 0.0319226 4.867470e-01 0.2513778 9.424965e-01 Syt17 up
26 CRYBB1 CRYBB1 -0.6315141 0.2924614 -2.159307 0.0308263 0.0275145 0.0308263 0.0323952 5.317860e-01 0.2997735 9.433667e-01 Crybb1 up
51 MEIG1 MEIG1 -1.5568552 0.7345368 -2.119506 0.0340477 0.0203682 0.0340477 0.0328155 2.107979e-01 0.0499606 8.894166e-01 Meig1 up
87 TRPC1 TRPC1 -0.9133696 0.4337654 -2.105676 0.0352325 0.0361240 0.0352325 0.0336084 4.011702e-01 0.1714379 9.387510e-01 Trpc1 up
88 TTLL11 TTLL11 1.6033388 0.7533240 2.128352 0.0333079 0.0457185 0.0333079 0.0338183 4.969597e+00 1.1352478 2.175463e+01 Ttll11 up
37 GRIA3 GRIA3 -0.5537059 0.2629723 -2.105567 0.0352420 0.0362229 0.0352420 0.0339876 5.748157e-01 0.3433098 9.624341e-01 Gria3 up
78 SPHKAP SPHKAP -0.3948747 0.1885112 -2.094701 0.0361976 0.0354954 0.0361976 0.0350410 6.737645e-01 0.4656365 9.749204e-01 Sphkap up
17 CES1 CES1 -1.2365117 0.6037801 -2.047950 0.0405649 0.0117912 0.0405649 0.0353114 2.903954e-01 0.0889306 9.482620e-01 Ces1d up
92 WNT4 WNT4 -0.8323685 0.4111895 -2.024294 0.0429399 0.0156938 0.0429399 0.0364697 4.350177e-01 0.1943130 9.738950e-01 Wnt4 up
29 FAM135B FAM135B -1.1288911 0.5417063 -2.083954 0.0371643 0.0296138 0.0371643 0.0366978 3.233917e-01 0.1118478 9.350398e-01 Fam135b up
57 NIPAL3 NIPAL3 0.3346470 0.1612557 2.075257 0.0379627 0.0390300 0.0379627 0.0369967 1.397447e+00 1.0187656 1.916887e+00 Nipal3 up
14 CCL27 CCL27 -8.0296337 4.5567387 -1.762145 0.0780448 0.0069579 0.0780448 0.0373252 3.257000e-04 0.0000000 2.463074e+00 Ccl27a up
54 MT3 MT3 0.3041427 0.1425664 2.133341 0.0328967 0.0234258 0.0328967 0.0395999 1.355462e+00 1.0250258 1.792422e+00 Mt3 up
47 LRRC6 LRRC6 -1.0838316 0.5327818 -2.034288 0.0419226 0.0388757 0.0419226 0.0396194 3.382968e-01 0.1190675 9.611754e-01 Lrrc6 up
81 TENM4 TENM4 -0.6701993 0.3295016 -2.033979 0.0419538 0.0392560 0.0419538 0.0413113 5.116066e-01 0.2682031 9.759070e-01 Tenm4 up
5 ALDOC ALDOC -0.3064586 0.1514231 -2.023857 0.0429849 0.0525149 0.0429849 0.0425914 7.360490e-01 0.5470351 9.903718e-01 Aldoc up
69 RAPGEF5 RAPGEF5 0.3193432 0.1604457 1.990350 0.0465524 0.0524216 0.0465524 0.0445547 1.376224e+00 1.0048872 1.884780e+00 Rapgef5 up
43 LDB3 LDB3 0.3834987 0.1921256 1.996083 0.0459248 0.0536589 0.0459248 0.0447002 1.467410e+00 1.0069636 2.138400e+00 Ldb3 up
33 GDF10 GDF10 -0.2476631 0.1253271 -1.976134 0.0481396 0.0394339 0.0481396 0.0457862 7.806229e-01 0.6106083 9.979755e-01 Gdf10 up
84 TPPP TPPP 0.2895090 0.1455712 1.988779 0.0467256 0.0504267 0.0467256 0.0459345 1.335771e+00 1.0042035 1.776817e+00 Tppp up
66 PPIL6 PPIL6 -0.8324625 0.4144059 -2.008809 0.0445573 0.0400225 0.0445573 0.0463260 4.349768e-01 0.1930737 9.799617e-01 Ppil6 up
23 CNTNAP4 CNTNAP4 0.4244264 0.2146225 1.977548 0.0479797 0.0526664 0.0479797 0.0466958 1.528713e+00 1.0037811 2.328161e+00 Cntnap4 up
31 FRY FRY -0.6944304 0.3511521 -1.977577 0.0479764 0.0486039 0.0479764 0.0472073 4.993588e-01 0.2509062 9.938342e-01 Fry up
41 IRX2 IRX2 -0.3255989 0.1648842 -1.974713 0.0483007 0.0587783 0.0483007 0.0477633 7.220948e-01 0.5226904 9.975711e-01 Irx2 down
11 CARTPT CARTPT 0.1630698 0.0843582 1.933065 0.0532282 0.0819939 0.0532282 0.0496218 1.177119e+00 0.9977334 1.388756e+00 Cartpt up
83 TMCO5A TMCO5A 82.6409564 43.6960941 1.891266 0.0585888 0.1037047 0.0585888 0.0498658 7.771616e+35 0.0496968 1.215330e+73 Tmco5 up

ONLY IDH

Gene-sets considered

UP and DOWN

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UP

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DOWN

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Table genes

Variable Term Beta StandardError Z P LRT Wald LogRank HR HRlower HRupper mm status
36 GPR139 GPR139 5.1595162 1.0707833 4.818450 0.0000014 0.0000396 0.0000014 0.0000000 1.740802e+02 21.3450416 1.419717e+03 Gpr139 up
61 PCDHGA3 PCDHGA3 0.7508024 0.2053482 3.656241 0.0002559 0.0025701 0.0002559 0.0000236 2.118699e+00 1.4166959 3.168560e+00 Pcdhga3 up
18 CHIC2 CHIC2 1.3148603 0.3211465 4.094269 0.0000424 0.0002660 0.0000424 0.0000446 3.724231e+00 1.9846144 6.988710e+00 Chic2 down
63 PHKG1 PHKG1 -0.6406674 0.1684263 -3.803845 0.0001425 0.0002338 0.0001425 0.0001123 5.269406e-01 0.3787887 7.330378e-01 Phkg1 up
3 ADAMTS3 ADAMTS3 3.2224925 1.0514520 3.064802 0.0021781 0.0093278 0.0021781 0.0001595 2.509058e+01 3.1953107 1.970191e+02 Adamts3 up
21 CLEC18A CLEC18A 2.8000255 0.7790372 3.594213 0.0003254 0.0014044 0.0003254 0.0001713 1.644507e+01 3.5720534 7.571001e+01 Clec18a up
46 LIX1 LIX1 -0.6899061 0.1972237 -3.498089 0.0004686 0.0005864 0.0004686 0.0003863 5.016232e-01 0.3408007 7.383372e-01 Lix1 up
72 SFTPC SFTPC 0.7150386 0.2109331 3.389884 0.0006992 0.0007212 0.0006992 0.0005360 2.044266e+00 1.3520438 3.090892e+00 Sftpc up
62 PCDHGA8 PCDHGA8 5.2362662 1.6538533 3.166101 0.0015450 0.0096278 0.0015450 0.0011135 1.879670e+02 7.3505362 4.806666e+03 Pcdhga8 up
93 ZBTB8B ZBTB8B 1.1365043 0.3520922 3.227860 0.0012472 0.0015945 0.0012472 0.0011193 3.115857e+00 1.5627018 6.212679e+00 Zbtb8b up
48 LRRK2 LRRK2 0.5470006 0.1760081 3.107815 0.0018848 0.0038480 0.0018848 0.0016209 1.728062e+00 1.2238861 2.439932e+00 Lrrk2 up
73 SH3GL2 SH3GL2 -0.7681192 0.2405062 -3.193760 0.0014043 0.0017402 0.0014043 0.0017373 4.638847e-01 0.2895282 7.432404e-01 Sh3gl2 up
56 MYH1 MYH1 6.4885350 2.3189710 2.798023 0.0051416 0.0245868 0.0051416 0.0019006 6.575594e+02 6.9826986 6.192224e+04 Myh1 up
10 BVES BVES 0.6492014 0.2109948 3.076860 0.0020919 0.0034852 0.0020919 0.0022376 1.914012e+00 1.2657428 2.894301e+00 Bves up
30 FAM186B FAM186B 3.6808737 1.2262259 3.001791 0.0026840 0.0048851 0.0026840 0.0028607 3.968105e+01 3.5877136 4.388828e+02 Fam186b up
77 SMIM1 SMIM1 0.8812849 0.3007913 2.929889 0.0033908 0.0049659 0.0033908 0.0032167 2.414000e+00 1.3387614 4.352825e+00 Smim1 up
4 AHCYL2 AHCYL2 -0.6577339 0.2262623 -2.906954 0.0036497 0.0028521 0.0036497 0.0033225 5.180239e-01 0.3324719 8.071320e-01 Ahcyl2 up
35 GLT8D2 GLT8D2 -2.1935510 0.7573641 -2.896297 0.0037760 0.0018451 0.0037760 0.0034438 1.115200e-01 0.0252746 4.920649e-01 Glt8d2 up
16 CEP135 CEP135 0.9612037 0.3279532 2.930917 0.0033796 0.0113210 0.0033796 0.0035540 2.614842e+00 1.3749635 4.972786e+00 Cep135 down
64 PLCXD1 PLCXD1 0.7187168 0.2420552 2.969226 0.0029855 0.0042069 0.0029855 0.0038072 2.051799e+00 1.2767238 3.297407e+00 Plcxd1 up
1 ABCA8 ABCA8 0.4570804 0.1554996 2.939431 0.0032882 0.0086596 0.0032882 0.0038081 1.579456e+00 1.1645174 2.142244e+00 Abca8b up
38 HHATL HHATL 0.3972220 0.1379059 2.880384 0.0039719 0.0037733 0.0039719 0.0039397 1.487686e+00 1.1353391 1.949383e+00 Hhatl up
19 CHRM5 CHRM5 1.9356194 0.6916367 2.798607 0.0051324 0.0113490 0.0051324 0.0039951 6.928334e+00 1.7861035 2.687516e+01 Chrm5 up
8 BARX2 BARX2 4.2196030 1.5075048 2.799064 0.0051251 0.0101462 0.0051251 0.0043039 6.800648e+01 3.5429083 1.305391e+03 Barx2 up
52 METTL11B METTL11B 2.5058448 0.9684965 2.587356 0.0096716 0.0338070 0.0096716 0.0050058 1.225391e+01 1.8360684 8.178248e+01 Mettl11b up
13 CCDC87 CCDC87 -0.6405216 0.2300130 -2.784719 0.0053574 0.0053539 0.0053574 0.0051444 5.270174e-01 0.3357666 8.272036e-01 Ccdc87 up
44 LGI3 LGI3 0.3468954 0.1262967 2.746671 0.0060204 0.0058834 0.0060204 0.0056087 1.414669e+00 1.1044621 1.812002e+00 Lgi3 up
90 TUB TUB -0.5353015 0.1944482 -2.752925 0.0059065 0.0069206 0.0059065 0.0057163 5.854927e-01 0.3999511 8.571092e-01 Tub up
74 SLC35F4 SLC35F4 7.7687589 3.3957542 2.287786 0.0221500 0.0864739 0.0221500 0.0063834 2.365534e+03 3.0440926 1.838232e+06 Slc35f4 up
85 TPSAB1 TPSAB1 -0.8846744 0.3542311 -2.497450 0.0125090 0.0006903 0.0125090 0.0063899 4.128486e-01 0.2061905 8.266333e-01 Tpsb2 down
39 HHIP HHIP 0.5059547 0.1893155 2.672548 0.0075278 0.0125895 0.0075278 0.0067012 1.658568e+00 1.1444259 2.403693e+00 Hhip up
25 CRTAC1 CRTAC1 -0.5325153 0.2040986 -2.609107 0.0090779 0.0096375 0.0090779 0.0088457 5.871263e-01 0.3935523 8.759123e-01 Crtac1 up
32 FXYD7 FXYD7 0.2876284 0.1121605 2.564436 0.0103343 0.0106282 0.0103343 0.0093643 1.333262e+00 1.0701490 1.661065e+00 Fxyd7 up
6 AOX3P AOX3P 11.3330802 4.4432645 2.550620 0.0107531 0.0331895 0.0107531 0.0097299 8.353995e+04 13.7968724 5.058337e+08 Aox3 up
76 SLCO4A1 SLCO4A1 0.5349134 0.2092046 2.556891 0.0105612 0.0149816 0.0105612 0.0103656 1.707300e+00 1.1330123 2.572677e+00 Slco4a1 up
91 VWC2 VWC2 -0.8658511 0.3444749 -2.513539 0.0119527 0.0076251 0.0119527 0.0104954 4.206934e-01 0.2141648 8.263865e-01 Vwc2 up
34 GLRA3 GLRA3 -0.7538191 0.3011341 -2.503267 0.0123053 0.0079996 0.0123053 0.0114512 4.705660e-01 0.2607922 8.490756e-01 Glra3 up
75 SLC8A3 SLC8A3 -0.6592973 0.2645167 -2.492460 0.0126862 0.0094084 0.0126862 0.0114866 5.172147e-01 0.3079738 8.686161e-01 Slc8a3 up
65 POPDC3 POPDC3 0.4728442 0.1902276 2.485676 0.0129306 0.0187433 0.0129306 0.0117812 1.604551e+00 1.1051763 2.329569e+00 Popdc3 up
86 TPSB2 TPSB2 -0.8013200 0.3290348 -2.435365 0.0148768 0.0022816 0.0148768 0.0118109 4.487363e-01 0.2354595 8.551968e-01 Tpsb2 down
58 NLRP6 NLRP6 0.6709421 0.2702415 2.482750 0.0130373 0.0218135 0.0130373 0.0125357 1.956079e+00 1.1517453 3.322128e+00 Nlrp6 up
60 PCDH7 PCDH7 -0.6628942 0.2660821 -2.491314 0.0127271 0.0104717 0.0127271 0.0125628 5.153577e-01 0.3059280 8.681569e-01 Pcdh7 up
24 CPA3 CPA3 -3.5762611 1.9488975 -1.835017 0.0665031 0.0007919 0.0665031 0.0136850 2.798010e-02 0.0006137 1.275716e+00 Cpa3 down
15 CDH7 CDH7 -0.8340137 0.3472870 -2.401512 0.0163275 0.0091114 0.0163275 0.0140317 4.343026e-01 0.2198777 8.578348e-01 Cdh7 up
2 ABLIM3 ABLIM3 -0.4808436 0.1974873 -2.434808 0.0148997 0.0152889 0.0148997 0.0144433 6.182616e-01 0.4198275 9.104870e-01 Ablim3 up
9 BMP3 BMP3 1.3553265 0.5709786 2.373690 0.0176113 0.0373274 0.0176113 0.0148387 3.878027e+00 1.2664643 1.187487e+01 Bmp3 up
45 LIPG LIPG -0.5180286 0.2142283 -2.418115 0.0156012 0.0156964 0.0156012 0.0151243 5.956937e-01 0.3914458 9.065139e-01 Lipg up
20 CHST15 CHST15 -0.5033978 0.2093893 -2.404124 0.0162113 0.0171423 0.0162113 0.0158504 6.044733e-01 0.4010002 9.111914e-01 Chst15 up
50 MAP6D1 MAP6D1 0.3774339 0.1582533 2.384999 0.0170792 0.0189951 0.0170792 0.0161717 1.458537e+00 1.0695770 1.988946e+00 Map6d1 up
67 PPP2R2B PPP2R2B -0.8738006 0.3636238 -2.403035 0.0162596 0.0143470 0.0162596 0.0162598 4.173623e-01 0.2046426 8.511975e-01 Ppp2r2b up
53 MGAT4C MGAT4C -1.3967395 0.5768181 -2.421456 0.0154585 0.0077684 0.0154585 0.0173673 2.474023e-01 0.0798758 7.662883e-01 Mgat4c up
49 LUZP2 LUZP2 -0.5286152 0.2259100 -2.339937 0.0192870 0.0215066 0.0192870 0.0185859 5.894206e-01 0.3785562 9.177414e-01 Luzp2 up
22 CLMN CLMN 0.6592381 0.2808949 2.346921 0.0189293 0.0300935 0.0189293 0.0196584 1.933319e+00 1.1148214 3.352753e+00 Clmn up
79 SPOCK3 SPOCK3 0.5432691 0.2349925 2.311857 0.0207855 0.0283806 0.0207855 0.0197538 1.721626e+00 1.0862075 2.728756e+00 Spock3 up
70 RNF32 RNF32 -0.8573740 0.3707326 -2.312648 0.0207420 0.0208589 0.0207420 0.0203103 4.242748e-01 0.2051536 8.774358e-01 Rnf32 up
59 NSUN7 NSUN7 3.4739776 1.5269652 2.275086 0.0229008 0.0292430 0.0229008 0.0214978 3.226482e+01 1.6179837 6.434050e+02 Nsun7 up
89 TTLL7 TTLL7 0.5323731 0.2360615 2.255231 0.0241189 0.0273676 0.0241189 0.0242335 1.702969e+00 1.0721876 2.704847e+00 Ttll7 up
7 ARHGAP8 ARHGAP8 20.8761762 9.4024620 2.220288 0.0263992 0.0399771 0.0263992 0.0246239 1.165220e+09 11.5616004 1.174352e+17 Arhgap8 down
82 TGM3 TGM3 -4.2363329 1.9422468 -2.181151 0.0291723 0.0073239 0.0291723 0.0251856 1.446050e-02 0.0003213 6.507699e-01 Tgm3 up
71 SERINC2 SERINC2 0.4735774 0.2137832 2.215223 0.0267448 0.0318912 0.0267448 0.0261266 1.605728e+00 1.0560865 2.441432e+00 Serinc2 up
55 MUSK MUSK 14.1949811 6.5867212 2.155091 0.0311547 0.0678555 0.0311547 0.0279285 1.461511e+06 3.6155532 5.907847e+11 Musk up
12 CCDC74B CCDC74B -0.5455931 0.2493796 -2.187802 0.0286840 0.0294507 0.0286840 0.0283321 5.794980e-01 0.3554509 9.447659e-01 Ccdc74a up
42 KCNG1 KCNG1 -0.4093191 0.1876366 -2.181446 0.0291504 0.0208728 0.0291504 0.0291734 6.641023e-01 0.4597465 9.592936e-01 Kcng1 up
28 FAM110B FAM110B -0.4469752 0.2066142 -2.163333 0.0305156 0.0322178 0.0305156 0.0297200 6.395597e-01 0.4265901 9.588517e-01 Fam110b up
68 PRSS35 PRSS35 -0.2598632 0.1208744 -2.149861 0.0315662 0.0362531 0.0315662 0.0299232 7.711571e-01 0.6084913 9.773077e-01 Prss35 up
27 EFCAB6 EFCAB6 -4.6697434 2.1733079 -2.148680 0.0316598 0.0230073 0.0316598 0.0302239 9.374700e-03 0.0001324 6.635586e-01 Efcab6 up
40 INHBA INHBA -0.7294275 0.3291556 -2.216057 0.0266876 0.0184006 0.0266876 0.0302935 4.821850e-01 0.2529507 9.191606e-01 Inhba up
80 SYT17 SYT17 -0.7200108 0.3371428 -2.135626 0.0327099 0.0303318 0.0327099 0.0319226 4.867470e-01 0.2513778 9.424965e-01 Syt17 up
26 CRYBB1 CRYBB1 -0.6315141 0.2924614 -2.159307 0.0308263 0.0275145 0.0308263 0.0323952 5.317860e-01 0.2997735 9.433667e-01 Crybb1 up
51 MEIG1 MEIG1 -1.5568552 0.7345368 -2.119506 0.0340477 0.0203682 0.0340477 0.0328155 2.107979e-01 0.0499606 8.894166e-01 Meig1 up
87 TRPC1 TRPC1 -0.9133696 0.4337654 -2.105676 0.0352325 0.0361240 0.0352325 0.0336084 4.011702e-01 0.1714379 9.387510e-01 Trpc1 up
88 TTLL11 TTLL11 1.6033388 0.7533240 2.128352 0.0333079 0.0457185 0.0333079 0.0338183 4.969597e+00 1.1352478 2.175463e+01 Ttll11 up
37 GRIA3 GRIA3 -0.5537059 0.2629723 -2.105567 0.0352420 0.0362229 0.0352420 0.0339876 5.748157e-01 0.3433098 9.624341e-01 Gria3 up
78 SPHKAP SPHKAP -0.3948747 0.1885112 -2.094701 0.0361976 0.0354954 0.0361976 0.0350410 6.737645e-01 0.4656365 9.749204e-01 Sphkap up
17 CES1 CES1 -1.2365117 0.6037801 -2.047950 0.0405649 0.0117912 0.0405649 0.0353114 2.903954e-01 0.0889306 9.482620e-01 Ces1d up
92 WNT4 WNT4 -0.8323685 0.4111895 -2.024294 0.0429399 0.0156938 0.0429399 0.0364697 4.350177e-01 0.1943130 9.738950e-01 Wnt4 up
29 FAM135B FAM135B -1.1288911 0.5417063 -2.083954 0.0371643 0.0296138 0.0371643 0.0366978 3.233917e-01 0.1118478 9.350398e-01 Fam135b up
57 NIPAL3 NIPAL3 0.3346470 0.1612557 2.075257 0.0379627 0.0390300 0.0379627 0.0369967 1.397447e+00 1.0187656 1.916887e+00 Nipal3 up
14 CCL27 CCL27 -8.0296337 4.5567387 -1.762145 0.0780448 0.0069579 0.0780448 0.0373252 3.257000e-04 0.0000000 2.463074e+00 Ccl27a up
54 MT3 MT3 0.3041427 0.1425664 2.133341 0.0328967 0.0234258 0.0328967 0.0395999 1.355462e+00 1.0250258 1.792422e+00 Mt3 up
47 LRRC6 LRRC6 -1.0838316 0.5327818 -2.034288 0.0419226 0.0388757 0.0419226 0.0396194 3.382968e-01 0.1190675 9.611754e-01 Lrrc6 up
81 TENM4 TENM4 -0.6701993 0.3295016 -2.033979 0.0419538 0.0392560 0.0419538 0.0413113 5.116066e-01 0.2682031 9.759070e-01 Tenm4 up
5 ALDOC ALDOC -0.3064586 0.1514231 -2.023857 0.0429849 0.0525149 0.0429849 0.0425914 7.360490e-01 0.5470351 9.903718e-01 Aldoc up
69 RAPGEF5 RAPGEF5 0.3193432 0.1604457 1.990350 0.0465524 0.0524216 0.0465524 0.0445547 1.376224e+00 1.0048872 1.884780e+00 Rapgef5 up
43 LDB3 LDB3 0.3834987 0.1921256 1.996083 0.0459248 0.0536589 0.0459248 0.0447002 1.467410e+00 1.0069636 2.138400e+00 Ldb3 up
33 GDF10 GDF10 -0.2476631 0.1253271 -1.976134 0.0481396 0.0394339 0.0481396 0.0457862 7.806229e-01 0.6106083 9.979755e-01 Gdf10 up
84 TPPP TPPP 0.2895090 0.1455712 1.988779 0.0467256 0.0504267 0.0467256 0.0459345 1.335771e+00 1.0042035 1.776817e+00 Tppp up
66 PPIL6 PPIL6 -0.8324625 0.4144059 -2.008809 0.0445573 0.0400225 0.0445573 0.0463260 4.349768e-01 0.1930737 9.799617e-01 Ppil6 up
23 CNTNAP4 CNTNAP4 0.4244264 0.2146225 1.977548 0.0479797 0.0526664 0.0479797 0.0466958 1.528713e+00 1.0037811 2.328161e+00 Cntnap4 up
31 FRY FRY -0.6944304 0.3511521 -1.977577 0.0479764 0.0486039 0.0479764 0.0472073 4.993588e-01 0.2509062 9.938342e-01 Fry up
41 IRX2 IRX2 -0.3255989 0.1648842 -1.974713 0.0483007 0.0587783 0.0483007 0.0477633 7.220948e-01 0.5226904 9.975711e-01 Irx2 down
11 CARTPT CARTPT 0.1630698 0.0843582 1.933065 0.0532282 0.0819939 0.0532282 0.0496218 1.177119e+00 0.9977334 1.388756e+00 Cartpt up
83 TMCO5A TMCO5A 82.6409564 43.6960941 1.891266 0.0585888 0.1037047 0.0585888 0.0498658 7.771616e+35 0.0496968 1.215330e+73 Tmco5 up

IDH_CODEL_NOCODEL

Gene-sets considered

UP and DOWN

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Table genes

Variable Term Beta StandardError Z P LRT Wald LogRank HR HRlower HRupper mm status
36 GPR139 GPR139 5.1595162 1.0707833 4.818450 0.0000014 0.0000396 0.0000014 0.0000000 1.740802e+02 21.3450416 1.419717e+03 Gpr139 up
61 PCDHGA3 PCDHGA3 0.7508024 0.2053482 3.656241 0.0002559 0.0025701 0.0002559 0.0000236 2.118699e+00 1.4166959 3.168560e+00 Pcdhga3 up
18 CHIC2 CHIC2 1.3148603 0.3211465 4.094269 0.0000424 0.0002660 0.0000424 0.0000446 3.724231e+00 1.9846144 6.988710e+00 Chic2 down
63 PHKG1 PHKG1 -0.6406674 0.1684263 -3.803845 0.0001425 0.0002338 0.0001425 0.0001123 5.269406e-01 0.3787887 7.330378e-01 Phkg1 up
3 ADAMTS3 ADAMTS3 3.2224925 1.0514520 3.064802 0.0021781 0.0093278 0.0021781 0.0001595 2.509058e+01 3.1953107 1.970191e+02 Adamts3 up
21 CLEC18A CLEC18A 2.8000255 0.7790372 3.594213 0.0003254 0.0014044 0.0003254 0.0001713 1.644507e+01 3.5720534 7.571001e+01 Clec18a up
46 LIX1 LIX1 -0.6899061 0.1972237 -3.498089 0.0004686 0.0005864 0.0004686 0.0003863 5.016232e-01 0.3408007 7.383372e-01 Lix1 up
72 SFTPC SFTPC 0.7150386 0.2109331 3.389884 0.0006992 0.0007212 0.0006992 0.0005360 2.044266e+00 1.3520438 3.090892e+00 Sftpc up
62 PCDHGA8 PCDHGA8 5.2362662 1.6538533 3.166101 0.0015450 0.0096278 0.0015450 0.0011135 1.879670e+02 7.3505362 4.806666e+03 Pcdhga8 up
93 ZBTB8B ZBTB8B 1.1365043 0.3520922 3.227860 0.0012472 0.0015945 0.0012472 0.0011193 3.115857e+00 1.5627018 6.212679e+00 Zbtb8b up
48 LRRK2 LRRK2 0.5470006 0.1760081 3.107815 0.0018848 0.0038480 0.0018848 0.0016209 1.728062e+00 1.2238861 2.439932e+00 Lrrk2 up
73 SH3GL2 SH3GL2 -0.7681192 0.2405062 -3.193760 0.0014043 0.0017402 0.0014043 0.0017373 4.638847e-01 0.2895282 7.432404e-01 Sh3gl2 up
56 MYH1 MYH1 6.4885350 2.3189710 2.798023 0.0051416 0.0245868 0.0051416 0.0019006 6.575594e+02 6.9826986 6.192224e+04 Myh1 up
10 BVES BVES 0.6492014 0.2109948 3.076860 0.0020919 0.0034852 0.0020919 0.0022376 1.914012e+00 1.2657428 2.894301e+00 Bves up
30 FAM186B FAM186B 3.6808737 1.2262259 3.001791 0.0026840 0.0048851 0.0026840 0.0028607 3.968105e+01 3.5877136 4.388828e+02 Fam186b up
77 SMIM1 SMIM1 0.8812849 0.3007913 2.929889 0.0033908 0.0049659 0.0033908 0.0032167 2.414000e+00 1.3387614 4.352825e+00 Smim1 up
4 AHCYL2 AHCYL2 -0.6577339 0.2262623 -2.906954 0.0036497 0.0028521 0.0036497 0.0033225 5.180239e-01 0.3324719 8.071320e-01 Ahcyl2 up
35 GLT8D2 GLT8D2 -2.1935510 0.7573641 -2.896297 0.0037760 0.0018451 0.0037760 0.0034438 1.115200e-01 0.0252746 4.920649e-01 Glt8d2 up
16 CEP135 CEP135 0.9612037 0.3279532 2.930917 0.0033796 0.0113210 0.0033796 0.0035540 2.614842e+00 1.3749635 4.972786e+00 Cep135 down
64 PLCXD1 PLCXD1 0.7187168 0.2420552 2.969226 0.0029855 0.0042069 0.0029855 0.0038072 2.051799e+00 1.2767238 3.297407e+00 Plcxd1 up
1 ABCA8 ABCA8 0.4570804 0.1554996 2.939431 0.0032882 0.0086596 0.0032882 0.0038081 1.579456e+00 1.1645174 2.142244e+00 Abca8b up
38 HHATL HHATL 0.3972220 0.1379059 2.880384 0.0039719 0.0037733 0.0039719 0.0039397 1.487686e+00 1.1353391 1.949383e+00 Hhatl up
19 CHRM5 CHRM5 1.9356194 0.6916367 2.798607 0.0051324 0.0113490 0.0051324 0.0039951 6.928334e+00 1.7861035 2.687516e+01 Chrm5 up
8 BARX2 BARX2 4.2196030 1.5075048 2.799064 0.0051251 0.0101462 0.0051251 0.0043039 6.800648e+01 3.5429083 1.305391e+03 Barx2 up
52 METTL11B METTL11B 2.5058448 0.9684965 2.587356 0.0096716 0.0338070 0.0096716 0.0050058 1.225391e+01 1.8360684 8.178248e+01 Mettl11b up
13 CCDC87 CCDC87 -0.6405216 0.2300130 -2.784719 0.0053574 0.0053539 0.0053574 0.0051444 5.270174e-01 0.3357666 8.272036e-01 Ccdc87 up
44 LGI3 LGI3 0.3468954 0.1262967 2.746671 0.0060204 0.0058834 0.0060204 0.0056087 1.414669e+00 1.1044621 1.812002e+00 Lgi3 up
90 TUB TUB -0.5353015 0.1944482 -2.752925 0.0059065 0.0069206 0.0059065 0.0057163 5.854927e-01 0.3999511 8.571092e-01 Tub up
74 SLC35F4 SLC35F4 7.7687589 3.3957542 2.287786 0.0221500 0.0864739 0.0221500 0.0063834 2.365534e+03 3.0440926 1.838232e+06 Slc35f4 up
85 TPSAB1 TPSAB1 -0.8846744 0.3542311 -2.497450 0.0125090 0.0006903 0.0125090 0.0063899 4.128486e-01 0.2061905 8.266333e-01 Tpsb2 down
39 HHIP HHIP 0.5059547 0.1893155 2.672548 0.0075278 0.0125895 0.0075278 0.0067012 1.658568e+00 1.1444259 2.403693e+00 Hhip up
25 CRTAC1 CRTAC1 -0.5325153 0.2040986 -2.609107 0.0090779 0.0096375 0.0090779 0.0088457 5.871263e-01 0.3935523 8.759123e-01 Crtac1 up
32 FXYD7 FXYD7 0.2876284 0.1121605 2.564436 0.0103343 0.0106282 0.0103343 0.0093643 1.333262e+00 1.0701490 1.661065e+00 Fxyd7 up
6 AOX3P AOX3P 11.3330802 4.4432645 2.550620 0.0107531 0.0331895 0.0107531 0.0097299 8.353995e+04 13.7968724 5.058337e+08 Aox3 up
76 SLCO4A1 SLCO4A1 0.5349134 0.2092046 2.556891 0.0105612 0.0149816 0.0105612 0.0103656 1.707300e+00 1.1330123 2.572677e+00 Slco4a1 up
91 VWC2 VWC2 -0.8658511 0.3444749 -2.513539 0.0119527 0.0076251 0.0119527 0.0104954 4.206934e-01 0.2141648 8.263865e-01 Vwc2 up
34 GLRA3 GLRA3 -0.7538191 0.3011341 -2.503267 0.0123053 0.0079996 0.0123053 0.0114512 4.705660e-01 0.2607922 8.490756e-01 Glra3 up
75 SLC8A3 SLC8A3 -0.6592973 0.2645167 -2.492460 0.0126862 0.0094084 0.0126862 0.0114866 5.172147e-01 0.3079738 8.686161e-01 Slc8a3 up
65 POPDC3 POPDC3 0.4728442 0.1902276 2.485676 0.0129306 0.0187433 0.0129306 0.0117812 1.604551e+00 1.1051763 2.329569e+00 Popdc3 up
86 TPSB2 TPSB2 -0.8013200 0.3290348 -2.435365 0.0148768 0.0022816 0.0148768 0.0118109 4.487363e-01 0.2354595 8.551968e-01 Tpsb2 down
58 NLRP6 NLRP6 0.6709421 0.2702415 2.482750 0.0130373 0.0218135 0.0130373 0.0125357 1.956079e+00 1.1517453 3.322128e+00 Nlrp6 up
60 PCDH7 PCDH7 -0.6628942 0.2660821 -2.491314 0.0127271 0.0104717 0.0127271 0.0125628 5.153577e-01 0.3059280 8.681569e-01 Pcdh7 up
24 CPA3 CPA3 -3.5762611 1.9488975 -1.835017 0.0665031 0.0007919 0.0665031 0.0136850 2.798010e-02 0.0006137 1.275716e+00 Cpa3 down
15 CDH7 CDH7 -0.8340137 0.3472870 -2.401512 0.0163275 0.0091114 0.0163275 0.0140317 4.343026e-01 0.2198777 8.578348e-01 Cdh7 up
2 ABLIM3 ABLIM3 -0.4808436 0.1974873 -2.434808 0.0148997 0.0152889 0.0148997 0.0144433 6.182616e-01 0.4198275 9.104870e-01 Ablim3 up
9 BMP3 BMP3 1.3553265 0.5709786 2.373690 0.0176113 0.0373274 0.0176113 0.0148387 3.878027e+00 1.2664643 1.187487e+01 Bmp3 up
45 LIPG LIPG -0.5180286 0.2142283 -2.418115 0.0156012 0.0156964 0.0156012 0.0151243 5.956937e-01 0.3914458 9.065139e-01 Lipg up
20 CHST15 CHST15 -0.5033978 0.2093893 -2.404124 0.0162113 0.0171423 0.0162113 0.0158504 6.044733e-01 0.4010002 9.111914e-01 Chst15 up
50 MAP6D1 MAP6D1 0.3774339 0.1582533 2.384999 0.0170792 0.0189951 0.0170792 0.0161717 1.458537e+00 1.0695770 1.988946e+00 Map6d1 up
67 PPP2R2B PPP2R2B -0.8738006 0.3636238 -2.403035 0.0162596 0.0143470 0.0162596 0.0162598 4.173623e-01 0.2046426 8.511975e-01 Ppp2r2b up
53 MGAT4C MGAT4C -1.3967395 0.5768181 -2.421456 0.0154585 0.0077684 0.0154585 0.0173673 2.474023e-01 0.0798758 7.662883e-01 Mgat4c up
49 LUZP2 LUZP2 -0.5286152 0.2259100 -2.339937 0.0192870 0.0215066 0.0192870 0.0185859 5.894206e-01 0.3785562 9.177414e-01 Luzp2 up
22 CLMN CLMN 0.6592381 0.2808949 2.346921 0.0189293 0.0300935 0.0189293 0.0196584 1.933319e+00 1.1148214 3.352753e+00 Clmn up
79 SPOCK3 SPOCK3 0.5432691 0.2349925 2.311857 0.0207855 0.0283806 0.0207855 0.0197538 1.721626e+00 1.0862075 2.728756e+00 Spock3 up
70 RNF32 RNF32 -0.8573740 0.3707326 -2.312648 0.0207420 0.0208589 0.0207420 0.0203103 4.242748e-01 0.2051536 8.774358e-01 Rnf32 up
59 NSUN7 NSUN7 3.4739776 1.5269652 2.275086 0.0229008 0.0292430 0.0229008 0.0214978 3.226482e+01 1.6179837 6.434050e+02 Nsun7 up
89 TTLL7 TTLL7 0.5323731 0.2360615 2.255231 0.0241189 0.0273676 0.0241189 0.0242335 1.702969e+00 1.0721876 2.704847e+00 Ttll7 up
7 ARHGAP8 ARHGAP8 20.8761762 9.4024620 2.220288 0.0263992 0.0399771 0.0263992 0.0246239 1.165220e+09 11.5616004 1.174352e+17 Arhgap8 down
82 TGM3 TGM3 -4.2363329 1.9422468 -2.181151 0.0291723 0.0073239 0.0291723 0.0251856 1.446050e-02 0.0003213 6.507699e-01 Tgm3 up
71 SERINC2 SERINC2 0.4735774 0.2137832 2.215223 0.0267448 0.0318912 0.0267448 0.0261266 1.605728e+00 1.0560865 2.441432e+00 Serinc2 up
55 MUSK MUSK 14.1949811 6.5867212 2.155091 0.0311547 0.0678555 0.0311547 0.0279285 1.461511e+06 3.6155532 5.907847e+11 Musk up
12 CCDC74B CCDC74B -0.5455931 0.2493796 -2.187802 0.0286840 0.0294507 0.0286840 0.0283321 5.794980e-01 0.3554509 9.447659e-01 Ccdc74a up
42 KCNG1 KCNG1 -0.4093191 0.1876366 -2.181446 0.0291504 0.0208728 0.0291504 0.0291734 6.641023e-01 0.4597465 9.592936e-01 Kcng1 up
28 FAM110B FAM110B -0.4469752 0.2066142 -2.163333 0.0305156 0.0322178 0.0305156 0.0297200 6.395597e-01 0.4265901 9.588517e-01 Fam110b up
68 PRSS35 PRSS35 -0.2598632 0.1208744 -2.149861 0.0315662 0.0362531 0.0315662 0.0299232 7.711571e-01 0.6084913 9.773077e-01 Prss35 up
27 EFCAB6 EFCAB6 -4.6697434 2.1733079 -2.148680 0.0316598 0.0230073 0.0316598 0.0302239 9.374700e-03 0.0001324 6.635586e-01 Efcab6 up
40 INHBA INHBA -0.7294275 0.3291556 -2.216057 0.0266876 0.0184006 0.0266876 0.0302935 4.821850e-01 0.2529507 9.191606e-01 Inhba up
80 SYT17 SYT17 -0.7200108 0.3371428 -2.135626 0.0327099 0.0303318 0.0327099 0.0319226 4.867470e-01 0.2513778 9.424965e-01 Syt17 up
26 CRYBB1 CRYBB1 -0.6315141 0.2924614 -2.159307 0.0308263 0.0275145 0.0308263 0.0323952 5.317860e-01 0.2997735 9.433667e-01 Crybb1 up
51 MEIG1 MEIG1 -1.5568552 0.7345368 -2.119506 0.0340477 0.0203682 0.0340477 0.0328155 2.107979e-01 0.0499606 8.894166e-01 Meig1 up
87 TRPC1 TRPC1 -0.9133696 0.4337654 -2.105676 0.0352325 0.0361240 0.0352325 0.0336084 4.011702e-01 0.1714379 9.387510e-01 Trpc1 up
88 TTLL11 TTLL11 1.6033388 0.7533240 2.128352 0.0333079 0.0457185 0.0333079 0.0338183 4.969597e+00 1.1352478 2.175463e+01 Ttll11 up
37 GRIA3 GRIA3 -0.5537059 0.2629723 -2.105567 0.0352420 0.0362229 0.0352420 0.0339876 5.748157e-01 0.3433098 9.624341e-01 Gria3 up
78 SPHKAP SPHKAP -0.3948747 0.1885112 -2.094701 0.0361976 0.0354954 0.0361976 0.0350410 6.737645e-01 0.4656365 9.749204e-01 Sphkap up
17 CES1 CES1 -1.2365117 0.6037801 -2.047950 0.0405649 0.0117912 0.0405649 0.0353114 2.903954e-01 0.0889306 9.482620e-01 Ces1d up
92 WNT4 WNT4 -0.8323685 0.4111895 -2.024294 0.0429399 0.0156938 0.0429399 0.0364697 4.350177e-01 0.1943130 9.738950e-01 Wnt4 up
29 FAM135B FAM135B -1.1288911 0.5417063 -2.083954 0.0371643 0.0296138 0.0371643 0.0366978 3.233917e-01 0.1118478 9.350398e-01 Fam135b up
57 NIPAL3 NIPAL3 0.3346470 0.1612557 2.075257 0.0379627 0.0390300 0.0379627 0.0369967 1.397447e+00 1.0187656 1.916887e+00 Nipal3 up
14 CCL27 CCL27 -8.0296337 4.5567387 -1.762145 0.0780448 0.0069579 0.0780448 0.0373252 3.257000e-04 0.0000000 2.463074e+00 Ccl27a up
54 MT3 MT3 0.3041427 0.1425664 2.133341 0.0328967 0.0234258 0.0328967 0.0395999 1.355462e+00 1.0250258 1.792422e+00 Mt3 up
47 LRRC6 LRRC6 -1.0838316 0.5327818 -2.034288 0.0419226 0.0388757 0.0419226 0.0396194 3.382968e-01 0.1190675 9.611754e-01 Lrrc6 up
81 TENM4 TENM4 -0.6701993 0.3295016 -2.033979 0.0419538 0.0392560 0.0419538 0.0413113 5.116066e-01 0.2682031 9.759070e-01 Tenm4 up
5 ALDOC ALDOC -0.3064586 0.1514231 -2.023857 0.0429849 0.0525149 0.0429849 0.0425914 7.360490e-01 0.5470351 9.903718e-01 Aldoc up
69 RAPGEF5 RAPGEF5 0.3193432 0.1604457 1.990350 0.0465524 0.0524216 0.0465524 0.0445547 1.376224e+00 1.0048872 1.884780e+00 Rapgef5 up
43 LDB3 LDB3 0.3834987 0.1921256 1.996083 0.0459248 0.0536589 0.0459248 0.0447002 1.467410e+00 1.0069636 2.138400e+00 Ldb3 up
33 GDF10 GDF10 -0.2476631 0.1253271 -1.976134 0.0481396 0.0394339 0.0481396 0.0457862 7.806229e-01 0.6106083 9.979755e-01 Gdf10 up
84 TPPP TPPP 0.2895090 0.1455712 1.988779 0.0467256 0.0504267 0.0467256 0.0459345 1.335771e+00 1.0042035 1.776817e+00 Tppp up
66 PPIL6 PPIL6 -0.8324625 0.4144059 -2.008809 0.0445573 0.0400225 0.0445573 0.0463260 4.349768e-01 0.1930737 9.799617e-01 Ppil6 up
23 CNTNAP4 CNTNAP4 0.4244264 0.2146225 1.977548 0.0479797 0.0526664 0.0479797 0.0466958 1.528713e+00 1.0037811 2.328161e+00 Cntnap4 up
31 FRY FRY -0.6944304 0.3511521 -1.977577 0.0479764 0.0486039 0.0479764 0.0472073 4.993588e-01 0.2509062 9.938342e-01 Fry up
41 IRX2 IRX2 -0.3255989 0.1648842 -1.974713 0.0483007 0.0587783 0.0483007 0.0477633 7.220948e-01 0.5226904 9.975711e-01 Irx2 down
11 CARTPT CARTPT 0.1630698 0.0843582 1.933065 0.0532282 0.0819939 0.0532282 0.0496218 1.177119e+00 0.9977334 1.388756e+00 Cartpt up
83 TMCO5A TMCO5A 82.6409564 43.6960941 1.891266 0.0585888 0.1037047 0.0585888 0.0498658 7.771616e+35 0.0496968 1.215330e+73 Tmco5 up

IDH_CODEL

Gene-sets considered

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Table genes

Variable Term Beta StandardError Z P LRT Wald LogRank HR HRlower HRupper mm status
36 GPR139 GPR139 5.1595162 1.0707833 4.818450 0.0000014 0.0000396 0.0000014 0.0000000 1.740802e+02 21.3450416 1.419717e+03 Gpr139 up
61 PCDHGA3 PCDHGA3 0.7508024 0.2053482 3.656241 0.0002559 0.0025701 0.0002559 0.0000236 2.118699e+00 1.4166959 3.168560e+00 Pcdhga3 up
18 CHIC2 CHIC2 1.3148603 0.3211465 4.094269 0.0000424 0.0002660 0.0000424 0.0000446 3.724231e+00 1.9846144 6.988710e+00 Chic2 down
63 PHKG1 PHKG1 -0.6406674 0.1684263 -3.803845 0.0001425 0.0002338 0.0001425 0.0001123 5.269406e-01 0.3787887 7.330378e-01 Phkg1 up
3 ADAMTS3 ADAMTS3 3.2224925 1.0514520 3.064802 0.0021781 0.0093278 0.0021781 0.0001595 2.509058e+01 3.1953107 1.970191e+02 Adamts3 up
21 CLEC18A CLEC18A 2.8000255 0.7790372 3.594213 0.0003254 0.0014044 0.0003254 0.0001713 1.644507e+01 3.5720534 7.571001e+01 Clec18a up
46 LIX1 LIX1 -0.6899061 0.1972237 -3.498089 0.0004686 0.0005864 0.0004686 0.0003863 5.016232e-01 0.3408007 7.383372e-01 Lix1 up
72 SFTPC SFTPC 0.7150386 0.2109331 3.389884 0.0006992 0.0007212 0.0006992 0.0005360 2.044266e+00 1.3520438 3.090892e+00 Sftpc up
62 PCDHGA8 PCDHGA8 5.2362662 1.6538533 3.166101 0.0015450 0.0096278 0.0015450 0.0011135 1.879670e+02 7.3505362 4.806666e+03 Pcdhga8 up
93 ZBTB8B ZBTB8B 1.1365043 0.3520922 3.227860 0.0012472 0.0015945 0.0012472 0.0011193 3.115857e+00 1.5627018 6.212679e+00 Zbtb8b up
48 LRRK2 LRRK2 0.5470006 0.1760081 3.107815 0.0018848 0.0038480 0.0018848 0.0016209 1.728062e+00 1.2238861 2.439932e+00 Lrrk2 up
73 SH3GL2 SH3GL2 -0.7681192 0.2405062 -3.193760 0.0014043 0.0017402 0.0014043 0.0017373 4.638847e-01 0.2895282 7.432404e-01 Sh3gl2 up
56 MYH1 MYH1 6.4885350 2.3189710 2.798023 0.0051416 0.0245868 0.0051416 0.0019006 6.575594e+02 6.9826986 6.192224e+04 Myh1 up
10 BVES BVES 0.6492014 0.2109948 3.076860 0.0020919 0.0034852 0.0020919 0.0022376 1.914012e+00 1.2657428 2.894301e+00 Bves up
30 FAM186B FAM186B 3.6808737 1.2262259 3.001791 0.0026840 0.0048851 0.0026840 0.0028607 3.968105e+01 3.5877136 4.388828e+02 Fam186b up
77 SMIM1 SMIM1 0.8812849 0.3007913 2.929889 0.0033908 0.0049659 0.0033908 0.0032167 2.414000e+00 1.3387614 4.352825e+00 Smim1 up
4 AHCYL2 AHCYL2 -0.6577339 0.2262623 -2.906954 0.0036497 0.0028521 0.0036497 0.0033225 5.180239e-01 0.3324719 8.071320e-01 Ahcyl2 up
35 GLT8D2 GLT8D2 -2.1935510 0.7573641 -2.896297 0.0037760 0.0018451 0.0037760 0.0034438 1.115200e-01 0.0252746 4.920649e-01 Glt8d2 up
16 CEP135 CEP135 0.9612037 0.3279532 2.930917 0.0033796 0.0113210 0.0033796 0.0035540 2.614842e+00 1.3749635 4.972786e+00 Cep135 down
64 PLCXD1 PLCXD1 0.7187168 0.2420552 2.969226 0.0029855 0.0042069 0.0029855 0.0038072 2.051799e+00 1.2767238 3.297407e+00 Plcxd1 up
1 ABCA8 ABCA8 0.4570804 0.1554996 2.939431 0.0032882 0.0086596 0.0032882 0.0038081 1.579456e+00 1.1645174 2.142244e+00 Abca8b up
38 HHATL HHATL 0.3972220 0.1379059 2.880384 0.0039719 0.0037733 0.0039719 0.0039397 1.487686e+00 1.1353391 1.949383e+00 Hhatl up
19 CHRM5 CHRM5 1.9356194 0.6916367 2.798607 0.0051324 0.0113490 0.0051324 0.0039951 6.928334e+00 1.7861035 2.687516e+01 Chrm5 up
8 BARX2 BARX2 4.2196030 1.5075048 2.799064 0.0051251 0.0101462 0.0051251 0.0043039 6.800648e+01 3.5429083 1.305391e+03 Barx2 up
52 METTL11B METTL11B 2.5058448 0.9684965 2.587356 0.0096716 0.0338070 0.0096716 0.0050058 1.225391e+01 1.8360684 8.178248e+01 Mettl11b up
13 CCDC87 CCDC87 -0.6405216 0.2300130 -2.784719 0.0053574 0.0053539 0.0053574 0.0051444 5.270174e-01 0.3357666 8.272036e-01 Ccdc87 up
44 LGI3 LGI3 0.3468954 0.1262967 2.746671 0.0060204 0.0058834 0.0060204 0.0056087 1.414669e+00 1.1044621 1.812002e+00 Lgi3 up
90 TUB TUB -0.5353015 0.1944482 -2.752925 0.0059065 0.0069206 0.0059065 0.0057163 5.854927e-01 0.3999511 8.571092e-01 Tub up
74 SLC35F4 SLC35F4 7.7687589 3.3957542 2.287786 0.0221500 0.0864739 0.0221500 0.0063834 2.365534e+03 3.0440926 1.838232e+06 Slc35f4 up
85 TPSAB1 TPSAB1 -0.8846744 0.3542311 -2.497450 0.0125090 0.0006903 0.0125090 0.0063899 4.128486e-01 0.2061905 8.266333e-01 Tpsb2 down
39 HHIP HHIP 0.5059547 0.1893155 2.672548 0.0075278 0.0125895 0.0075278 0.0067012 1.658568e+00 1.1444259 2.403693e+00 Hhip up
25 CRTAC1 CRTAC1 -0.5325153 0.2040986 -2.609107 0.0090779 0.0096375 0.0090779 0.0088457 5.871263e-01 0.3935523 8.759123e-01 Crtac1 up
32 FXYD7 FXYD7 0.2876284 0.1121605 2.564436 0.0103343 0.0106282 0.0103343 0.0093643 1.333262e+00 1.0701490 1.661065e+00 Fxyd7 up
6 AOX3P AOX3P 11.3330802 4.4432645 2.550620 0.0107531 0.0331895 0.0107531 0.0097299 8.353995e+04 13.7968724 5.058337e+08 Aox3 up
76 SLCO4A1 SLCO4A1 0.5349134 0.2092046 2.556891 0.0105612 0.0149816 0.0105612 0.0103656 1.707300e+00 1.1330123 2.572677e+00 Slco4a1 up
91 VWC2 VWC2 -0.8658511 0.3444749 -2.513539 0.0119527 0.0076251 0.0119527 0.0104954 4.206934e-01 0.2141648 8.263865e-01 Vwc2 up
34 GLRA3 GLRA3 -0.7538191 0.3011341 -2.503267 0.0123053 0.0079996 0.0123053 0.0114512 4.705660e-01 0.2607922 8.490756e-01 Glra3 up
75 SLC8A3 SLC8A3 -0.6592973 0.2645167 -2.492460 0.0126862 0.0094084 0.0126862 0.0114866 5.172147e-01 0.3079738 8.686161e-01 Slc8a3 up
65 POPDC3 POPDC3 0.4728442 0.1902276 2.485676 0.0129306 0.0187433 0.0129306 0.0117812 1.604551e+00 1.1051763 2.329569e+00 Popdc3 up
86 TPSB2 TPSB2 -0.8013200 0.3290348 -2.435365 0.0148768 0.0022816 0.0148768 0.0118109 4.487363e-01 0.2354595 8.551968e-01 Tpsb2 down
58 NLRP6 NLRP6 0.6709421 0.2702415 2.482750 0.0130373 0.0218135 0.0130373 0.0125357 1.956079e+00 1.1517453 3.322128e+00 Nlrp6 up
60 PCDH7 PCDH7 -0.6628942 0.2660821 -2.491314 0.0127271 0.0104717 0.0127271 0.0125628 5.153577e-01 0.3059280 8.681569e-01 Pcdh7 up
24 CPA3 CPA3 -3.5762611 1.9488975 -1.835017 0.0665031 0.0007919 0.0665031 0.0136850 2.798010e-02 0.0006137 1.275716e+00 Cpa3 down
15 CDH7 CDH7 -0.8340137 0.3472870 -2.401512 0.0163275 0.0091114 0.0163275 0.0140317 4.343026e-01 0.2198777 8.578348e-01 Cdh7 up
2 ABLIM3 ABLIM3 -0.4808436 0.1974873 -2.434808 0.0148997 0.0152889 0.0148997 0.0144433 6.182616e-01 0.4198275 9.104870e-01 Ablim3 up
9 BMP3 BMP3 1.3553265 0.5709786 2.373690 0.0176113 0.0373274 0.0176113 0.0148387 3.878027e+00 1.2664643 1.187487e+01 Bmp3 up
45 LIPG LIPG -0.5180286 0.2142283 -2.418115 0.0156012 0.0156964 0.0156012 0.0151243 5.956937e-01 0.3914458 9.065139e-01 Lipg up
20 CHST15 CHST15 -0.5033978 0.2093893 -2.404124 0.0162113 0.0171423 0.0162113 0.0158504 6.044733e-01 0.4010002 9.111914e-01 Chst15 up
50 MAP6D1 MAP6D1 0.3774339 0.1582533 2.384999 0.0170792 0.0189951 0.0170792 0.0161717 1.458537e+00 1.0695770 1.988946e+00 Map6d1 up
67 PPP2R2B PPP2R2B -0.8738006 0.3636238 -2.403035 0.0162596 0.0143470 0.0162596 0.0162598 4.173623e-01 0.2046426 8.511975e-01 Ppp2r2b up
53 MGAT4C MGAT4C -1.3967395 0.5768181 -2.421456 0.0154585 0.0077684 0.0154585 0.0173673 2.474023e-01 0.0798758 7.662883e-01 Mgat4c up
49 LUZP2 LUZP2 -0.5286152 0.2259100 -2.339937 0.0192870 0.0215066 0.0192870 0.0185859 5.894206e-01 0.3785562 9.177414e-01 Luzp2 up
22 CLMN CLMN 0.6592381 0.2808949 2.346921 0.0189293 0.0300935 0.0189293 0.0196584 1.933319e+00 1.1148214 3.352753e+00 Clmn up
79 SPOCK3 SPOCK3 0.5432691 0.2349925 2.311857 0.0207855 0.0283806 0.0207855 0.0197538 1.721626e+00 1.0862075 2.728756e+00 Spock3 up
70 RNF32 RNF32 -0.8573740 0.3707326 -2.312648 0.0207420 0.0208589 0.0207420 0.0203103 4.242748e-01 0.2051536 8.774358e-01 Rnf32 up
59 NSUN7 NSUN7 3.4739776 1.5269652 2.275086 0.0229008 0.0292430 0.0229008 0.0214978 3.226482e+01 1.6179837 6.434050e+02 Nsun7 up
89 TTLL7 TTLL7 0.5323731 0.2360615 2.255231 0.0241189 0.0273676 0.0241189 0.0242335 1.702969e+00 1.0721876 2.704847e+00 Ttll7 up
7 ARHGAP8 ARHGAP8 20.8761762 9.4024620 2.220288 0.0263992 0.0399771 0.0263992 0.0246239 1.165220e+09 11.5616004 1.174352e+17 Arhgap8 down
82 TGM3 TGM3 -4.2363329 1.9422468 -2.181151 0.0291723 0.0073239 0.0291723 0.0251856 1.446050e-02 0.0003213 6.507699e-01 Tgm3 up
71 SERINC2 SERINC2 0.4735774 0.2137832 2.215223 0.0267448 0.0318912 0.0267448 0.0261266 1.605728e+00 1.0560865 2.441432e+00 Serinc2 up
55 MUSK MUSK 14.1949811 6.5867212 2.155091 0.0311547 0.0678555 0.0311547 0.0279285 1.461511e+06 3.6155532 5.907847e+11 Musk up
12 CCDC74B CCDC74B -0.5455931 0.2493796 -2.187802 0.0286840 0.0294507 0.0286840 0.0283321 5.794980e-01 0.3554509 9.447659e-01 Ccdc74a up
42 KCNG1 KCNG1 -0.4093191 0.1876366 -2.181446 0.0291504 0.0208728 0.0291504 0.0291734 6.641023e-01 0.4597465 9.592936e-01 Kcng1 up
28 FAM110B FAM110B -0.4469752 0.2066142 -2.163333 0.0305156 0.0322178 0.0305156 0.0297200 6.395597e-01 0.4265901 9.588517e-01 Fam110b up
68 PRSS35 PRSS35 -0.2598632 0.1208744 -2.149861 0.0315662 0.0362531 0.0315662 0.0299232 7.711571e-01 0.6084913 9.773077e-01 Prss35 up
27 EFCAB6 EFCAB6 -4.6697434 2.1733079 -2.148680 0.0316598 0.0230073 0.0316598 0.0302239 9.374700e-03 0.0001324 6.635586e-01 Efcab6 up
40 INHBA INHBA -0.7294275 0.3291556 -2.216057 0.0266876 0.0184006 0.0266876 0.0302935 4.821850e-01 0.2529507 9.191606e-01 Inhba up
80 SYT17 SYT17 -0.7200108 0.3371428 -2.135626 0.0327099 0.0303318 0.0327099 0.0319226 4.867470e-01 0.2513778 9.424965e-01 Syt17 up
26 CRYBB1 CRYBB1 -0.6315141 0.2924614 -2.159307 0.0308263 0.0275145 0.0308263 0.0323952 5.317860e-01 0.2997735 9.433667e-01 Crybb1 up
51 MEIG1 MEIG1 -1.5568552 0.7345368 -2.119506 0.0340477 0.0203682 0.0340477 0.0328155 2.107979e-01 0.0499606 8.894166e-01 Meig1 up
87 TRPC1 TRPC1 -0.9133696 0.4337654 -2.105676 0.0352325 0.0361240 0.0352325 0.0336084 4.011702e-01 0.1714379 9.387510e-01 Trpc1 up
88 TTLL11 TTLL11 1.6033388 0.7533240 2.128352 0.0333079 0.0457185 0.0333079 0.0338183 4.969597e+00 1.1352478 2.175463e+01 Ttll11 up
37 GRIA3 GRIA3 -0.5537059 0.2629723 -2.105567 0.0352420 0.0362229 0.0352420 0.0339876 5.748157e-01 0.3433098 9.624341e-01 Gria3 up
78 SPHKAP SPHKAP -0.3948747 0.1885112 -2.094701 0.0361976 0.0354954 0.0361976 0.0350410 6.737645e-01 0.4656365 9.749204e-01 Sphkap up
17 CES1 CES1 -1.2365117 0.6037801 -2.047950 0.0405649 0.0117912 0.0405649 0.0353114 2.903954e-01 0.0889306 9.482620e-01 Ces1d up
92 WNT4 WNT4 -0.8323685 0.4111895 -2.024294 0.0429399 0.0156938 0.0429399 0.0364697 4.350177e-01 0.1943130 9.738950e-01 Wnt4 up
29 FAM135B FAM135B -1.1288911 0.5417063 -2.083954 0.0371643 0.0296138 0.0371643 0.0366978 3.233917e-01 0.1118478 9.350398e-01 Fam135b up
57 NIPAL3 NIPAL3 0.3346470 0.1612557 2.075257 0.0379627 0.0390300 0.0379627 0.0369967 1.397447e+00 1.0187656 1.916887e+00 Nipal3 up
14 CCL27 CCL27 -8.0296337 4.5567387 -1.762145 0.0780448 0.0069579 0.0780448 0.0373252 3.257000e-04 0.0000000 2.463074e+00 Ccl27a up
54 MT3 MT3 0.3041427 0.1425664 2.133341 0.0328967 0.0234258 0.0328967 0.0395999 1.355462e+00 1.0250258 1.792422e+00 Mt3 up
47 LRRC6 LRRC6 -1.0838316 0.5327818 -2.034288 0.0419226 0.0388757 0.0419226 0.0396194 3.382968e-01 0.1190675 9.611754e-01 Lrrc6 up
81 TENM4 TENM4 -0.6701993 0.3295016 -2.033979 0.0419538 0.0392560 0.0419538 0.0413113 5.116066e-01 0.2682031 9.759070e-01 Tenm4 up
5 ALDOC ALDOC -0.3064586 0.1514231 -2.023857 0.0429849 0.0525149 0.0429849 0.0425914 7.360490e-01 0.5470351 9.903718e-01 Aldoc up
69 RAPGEF5 RAPGEF5 0.3193432 0.1604457 1.990350 0.0465524 0.0524216 0.0465524 0.0445547 1.376224e+00 1.0048872 1.884780e+00 Rapgef5 up
43 LDB3 LDB3 0.3834987 0.1921256 1.996083 0.0459248 0.0536589 0.0459248 0.0447002 1.467410e+00 1.0069636 2.138400e+00 Ldb3 up
33 GDF10 GDF10 -0.2476631 0.1253271 -1.976134 0.0481396 0.0394339 0.0481396 0.0457862 7.806229e-01 0.6106083 9.979755e-01 Gdf10 up
84 TPPP TPPP 0.2895090 0.1455712 1.988779 0.0467256 0.0504267 0.0467256 0.0459345 1.335771e+00 1.0042035 1.776817e+00 Tppp up
66 PPIL6 PPIL6 -0.8324625 0.4144059 -2.008809 0.0445573 0.0400225 0.0445573 0.0463260 4.349768e-01 0.1930737 9.799617e-01 Ppil6 up
23 CNTNAP4 CNTNAP4 0.4244264 0.2146225 1.977548 0.0479797 0.0526664 0.0479797 0.0466958 1.528713e+00 1.0037811 2.328161e+00 Cntnap4 up
31 FRY FRY -0.6944304 0.3511521 -1.977577 0.0479764 0.0486039 0.0479764 0.0472073 4.993588e-01 0.2509062 9.938342e-01 Fry up
41 IRX2 IRX2 -0.3255989 0.1648842 -1.974713 0.0483007 0.0587783 0.0483007 0.0477633 7.220948e-01 0.5226904 9.975711e-01 Irx2 down
11 CARTPT CARTPT 0.1630698 0.0843582 1.933065 0.0532282 0.0819939 0.0532282 0.0496218 1.177119e+00 0.9977334 1.388756e+00 Cartpt up
83 TMCO5A TMCO5A 82.6409564 43.6960941 1.891266 0.0585888 0.1037047 0.0585888 0.0498658 7.771616e+35 0.0496968 1.215330e+73 Tmco5 up

IDH_NOCODEL

Gene-sets considered

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Table genes

Variable Term Beta StandardError Z P LRT Wald LogRank HR HRlower HRupper mm status
36 GPR139 GPR139 5.1595162 1.0707833 4.818450 0.0000014 0.0000396 0.0000014 0.0000000 1.740802e+02 21.3450416 1.419717e+03 Gpr139 up
61 PCDHGA3 PCDHGA3 0.7508024 0.2053482 3.656241 0.0002559 0.0025701 0.0002559 0.0000236 2.118699e+00 1.4166959 3.168560e+00 Pcdhga3 up
18 CHIC2 CHIC2 1.3148603 0.3211465 4.094269 0.0000424 0.0002660 0.0000424 0.0000446 3.724231e+00 1.9846144 6.988710e+00 Chic2 down
63 PHKG1 PHKG1 -0.6406674 0.1684263 -3.803845 0.0001425 0.0002338 0.0001425 0.0001123 5.269406e-01 0.3787887 7.330378e-01 Phkg1 up
3 ADAMTS3 ADAMTS3 3.2224925 1.0514520 3.064802 0.0021781 0.0093278 0.0021781 0.0001595 2.509058e+01 3.1953107 1.970191e+02 Adamts3 up
21 CLEC18A CLEC18A 2.8000255 0.7790372 3.594213 0.0003254 0.0014044 0.0003254 0.0001713 1.644507e+01 3.5720534 7.571001e+01 Clec18a up
46 LIX1 LIX1 -0.6899061 0.1972237 -3.498089 0.0004686 0.0005864 0.0004686 0.0003863 5.016232e-01 0.3408007 7.383372e-01 Lix1 up
72 SFTPC SFTPC 0.7150386 0.2109331 3.389884 0.0006992 0.0007212 0.0006992 0.0005360 2.044266e+00 1.3520438 3.090892e+00 Sftpc up
62 PCDHGA8 PCDHGA8 5.2362662 1.6538533 3.166101 0.0015450 0.0096278 0.0015450 0.0011135 1.879670e+02 7.3505362 4.806666e+03 Pcdhga8 up
93 ZBTB8B ZBTB8B 1.1365043 0.3520922 3.227860 0.0012472 0.0015945 0.0012472 0.0011193 3.115857e+00 1.5627018 6.212679e+00 Zbtb8b up
48 LRRK2 LRRK2 0.5470006 0.1760081 3.107815 0.0018848 0.0038480 0.0018848 0.0016209 1.728062e+00 1.2238861 2.439932e+00 Lrrk2 up
73 SH3GL2 SH3GL2 -0.7681192 0.2405062 -3.193760 0.0014043 0.0017402 0.0014043 0.0017373 4.638847e-01 0.2895282 7.432404e-01 Sh3gl2 up
56 MYH1 MYH1 6.4885350 2.3189710 2.798023 0.0051416 0.0245868 0.0051416 0.0019006 6.575594e+02 6.9826986 6.192224e+04 Myh1 up
10 BVES BVES 0.6492014 0.2109948 3.076860 0.0020919 0.0034852 0.0020919 0.0022376 1.914012e+00 1.2657428 2.894301e+00 Bves up
30 FAM186B FAM186B 3.6808737 1.2262259 3.001791 0.0026840 0.0048851 0.0026840 0.0028607 3.968105e+01 3.5877136 4.388828e+02 Fam186b up
77 SMIM1 SMIM1 0.8812849 0.3007913 2.929889 0.0033908 0.0049659 0.0033908 0.0032167 2.414000e+00 1.3387614 4.352825e+00 Smim1 up
4 AHCYL2 AHCYL2 -0.6577339 0.2262623 -2.906954 0.0036497 0.0028521 0.0036497 0.0033225 5.180239e-01 0.3324719 8.071320e-01 Ahcyl2 up
35 GLT8D2 GLT8D2 -2.1935510 0.7573641 -2.896297 0.0037760 0.0018451 0.0037760 0.0034438 1.115200e-01 0.0252746 4.920649e-01 Glt8d2 up
16 CEP135 CEP135 0.9612037 0.3279532 2.930917 0.0033796 0.0113210 0.0033796 0.0035540 2.614842e+00 1.3749635 4.972786e+00 Cep135 down
64 PLCXD1 PLCXD1 0.7187168 0.2420552 2.969226 0.0029855 0.0042069 0.0029855 0.0038072 2.051799e+00 1.2767238 3.297407e+00 Plcxd1 up
1 ABCA8 ABCA8 0.4570804 0.1554996 2.939431 0.0032882 0.0086596 0.0032882 0.0038081 1.579456e+00 1.1645174 2.142244e+00 Abca8b up
38 HHATL HHATL 0.3972220 0.1379059 2.880384 0.0039719 0.0037733 0.0039719 0.0039397 1.487686e+00 1.1353391 1.949383e+00 Hhatl up
19 CHRM5 CHRM5 1.9356194 0.6916367 2.798607 0.0051324 0.0113490 0.0051324 0.0039951 6.928334e+00 1.7861035 2.687516e+01 Chrm5 up
8 BARX2 BARX2 4.2196030 1.5075048 2.799064 0.0051251 0.0101462 0.0051251 0.0043039 6.800648e+01 3.5429083 1.305391e+03 Barx2 up
52 METTL11B METTL11B 2.5058448 0.9684965 2.587356 0.0096716 0.0338070 0.0096716 0.0050058 1.225391e+01 1.8360684 8.178248e+01 Mettl11b up
13 CCDC87 CCDC87 -0.6405216 0.2300130 -2.784719 0.0053574 0.0053539 0.0053574 0.0051444 5.270174e-01 0.3357666 8.272036e-01 Ccdc87 up
44 LGI3 LGI3 0.3468954 0.1262967 2.746671 0.0060204 0.0058834 0.0060204 0.0056087 1.414669e+00 1.1044621 1.812002e+00 Lgi3 up
90 TUB TUB -0.5353015 0.1944482 -2.752925 0.0059065 0.0069206 0.0059065 0.0057163 5.854927e-01 0.3999511 8.571092e-01 Tub up
74 SLC35F4 SLC35F4 7.7687589 3.3957542 2.287786 0.0221500 0.0864739 0.0221500 0.0063834 2.365534e+03 3.0440926 1.838232e+06 Slc35f4 up
85 TPSAB1 TPSAB1 -0.8846744 0.3542311 -2.497450 0.0125090 0.0006903 0.0125090 0.0063899 4.128486e-01 0.2061905 8.266333e-01 Tpsb2 down
39 HHIP HHIP 0.5059547 0.1893155 2.672548 0.0075278 0.0125895 0.0075278 0.0067012 1.658568e+00 1.1444259 2.403693e+00 Hhip up
25 CRTAC1 CRTAC1 -0.5325153 0.2040986 -2.609107 0.0090779 0.0096375 0.0090779 0.0088457 5.871263e-01 0.3935523 8.759123e-01 Crtac1 up
32 FXYD7 FXYD7 0.2876284 0.1121605 2.564436 0.0103343 0.0106282 0.0103343 0.0093643 1.333262e+00 1.0701490 1.661065e+00 Fxyd7 up
6 AOX3P AOX3P 11.3330802 4.4432645 2.550620 0.0107531 0.0331895 0.0107531 0.0097299 8.353995e+04 13.7968724 5.058337e+08 Aox3 up
76 SLCO4A1 SLCO4A1 0.5349134 0.2092046 2.556891 0.0105612 0.0149816 0.0105612 0.0103656 1.707300e+00 1.1330123 2.572677e+00 Slco4a1 up
91 VWC2 VWC2 -0.8658511 0.3444749 -2.513539 0.0119527 0.0076251 0.0119527 0.0104954 4.206934e-01 0.2141648 8.263865e-01 Vwc2 up
34 GLRA3 GLRA3 -0.7538191 0.3011341 -2.503267 0.0123053 0.0079996 0.0123053 0.0114512 4.705660e-01 0.2607922 8.490756e-01 Glra3 up
75 SLC8A3 SLC8A3 -0.6592973 0.2645167 -2.492460 0.0126862 0.0094084 0.0126862 0.0114866 5.172147e-01 0.3079738 8.686161e-01 Slc8a3 up
65 POPDC3 POPDC3 0.4728442 0.1902276 2.485676 0.0129306 0.0187433 0.0129306 0.0117812 1.604551e+00 1.1051763 2.329569e+00 Popdc3 up
86 TPSB2 TPSB2 -0.8013200 0.3290348 -2.435365 0.0148768 0.0022816 0.0148768 0.0118109 4.487363e-01 0.2354595 8.551968e-01 Tpsb2 down
58 NLRP6 NLRP6 0.6709421 0.2702415 2.482750 0.0130373 0.0218135 0.0130373 0.0125357 1.956079e+00 1.1517453 3.322128e+00 Nlrp6 up
60 PCDH7 PCDH7 -0.6628942 0.2660821 -2.491314 0.0127271 0.0104717 0.0127271 0.0125628 5.153577e-01 0.3059280 8.681569e-01 Pcdh7 up
24 CPA3 CPA3 -3.5762611 1.9488975 -1.835017 0.0665031 0.0007919 0.0665031 0.0136850 2.798010e-02 0.0006137 1.275716e+00 Cpa3 down
15 CDH7 CDH7 -0.8340137 0.3472870 -2.401512 0.0163275 0.0091114 0.0163275 0.0140317 4.343026e-01 0.2198777 8.578348e-01 Cdh7 up
2 ABLIM3 ABLIM3 -0.4808436 0.1974873 -2.434808 0.0148997 0.0152889 0.0148997 0.0144433 6.182616e-01 0.4198275 9.104870e-01 Ablim3 up
9 BMP3 BMP3 1.3553265 0.5709786 2.373690 0.0176113 0.0373274 0.0176113 0.0148387 3.878027e+00 1.2664643 1.187487e+01 Bmp3 up
45 LIPG LIPG -0.5180286 0.2142283 -2.418115 0.0156012 0.0156964 0.0156012 0.0151243 5.956937e-01 0.3914458 9.065139e-01 Lipg up
20 CHST15 CHST15 -0.5033978 0.2093893 -2.404124 0.0162113 0.0171423 0.0162113 0.0158504 6.044733e-01 0.4010002 9.111914e-01 Chst15 up
50 MAP6D1 MAP6D1 0.3774339 0.1582533 2.384999 0.0170792 0.0189951 0.0170792 0.0161717 1.458537e+00 1.0695770 1.988946e+00 Map6d1 up
67 PPP2R2B PPP2R2B -0.8738006 0.3636238 -2.403035 0.0162596 0.0143470 0.0162596 0.0162598 4.173623e-01 0.2046426 8.511975e-01 Ppp2r2b up
53 MGAT4C MGAT4C -1.3967395 0.5768181 -2.421456 0.0154585 0.0077684 0.0154585 0.0173673 2.474023e-01 0.0798758 7.662883e-01 Mgat4c up
49 LUZP2 LUZP2 -0.5286152 0.2259100 -2.339937 0.0192870 0.0215066 0.0192870 0.0185859 5.894206e-01 0.3785562 9.177414e-01 Luzp2 up
22 CLMN CLMN 0.6592381 0.2808949 2.346921 0.0189293 0.0300935 0.0189293 0.0196584 1.933319e+00 1.1148214 3.352753e+00 Clmn up
79 SPOCK3 SPOCK3 0.5432691 0.2349925 2.311857 0.0207855 0.0283806 0.0207855 0.0197538 1.721626e+00 1.0862075 2.728756e+00 Spock3 up
70 RNF32 RNF32 -0.8573740 0.3707326 -2.312648 0.0207420 0.0208589 0.0207420 0.0203103 4.242748e-01 0.2051536 8.774358e-01 Rnf32 up
59 NSUN7 NSUN7 3.4739776 1.5269652 2.275086 0.0229008 0.0292430 0.0229008 0.0214978 3.226482e+01 1.6179837 6.434050e+02 Nsun7 up
89 TTLL7 TTLL7 0.5323731 0.2360615 2.255231 0.0241189 0.0273676 0.0241189 0.0242335 1.702969e+00 1.0721876 2.704847e+00 Ttll7 up
7 ARHGAP8 ARHGAP8 20.8761762 9.4024620 2.220288 0.0263992 0.0399771 0.0263992 0.0246239 1.165220e+09 11.5616004 1.174352e+17 Arhgap8 down
82 TGM3 TGM3 -4.2363329 1.9422468 -2.181151 0.0291723 0.0073239 0.0291723 0.0251856 1.446050e-02 0.0003213 6.507699e-01 Tgm3 up
71 SERINC2 SERINC2 0.4735774 0.2137832 2.215223 0.0267448 0.0318912 0.0267448 0.0261266 1.605728e+00 1.0560865 2.441432e+00 Serinc2 up
55 MUSK MUSK 14.1949811 6.5867212 2.155091 0.0311547 0.0678555 0.0311547 0.0279285 1.461511e+06 3.6155532 5.907847e+11 Musk up
12 CCDC74B CCDC74B -0.5455931 0.2493796 -2.187802 0.0286840 0.0294507 0.0286840 0.0283321 5.794980e-01 0.3554509 9.447659e-01 Ccdc74a up
42 KCNG1 KCNG1 -0.4093191 0.1876366 -2.181446 0.0291504 0.0208728 0.0291504 0.0291734 6.641023e-01 0.4597465 9.592936e-01 Kcng1 up
28 FAM110B FAM110B -0.4469752 0.2066142 -2.163333 0.0305156 0.0322178 0.0305156 0.0297200 6.395597e-01 0.4265901 9.588517e-01 Fam110b up
68 PRSS35 PRSS35 -0.2598632 0.1208744 -2.149861 0.0315662 0.0362531 0.0315662 0.0299232 7.711571e-01 0.6084913 9.773077e-01 Prss35 up
27 EFCAB6 EFCAB6 -4.6697434 2.1733079 -2.148680 0.0316598 0.0230073 0.0316598 0.0302239 9.374700e-03 0.0001324 6.635586e-01 Efcab6 up
40 INHBA INHBA -0.7294275 0.3291556 -2.216057 0.0266876 0.0184006 0.0266876 0.0302935 4.821850e-01 0.2529507 9.191606e-01 Inhba up
80 SYT17 SYT17 -0.7200108 0.3371428 -2.135626 0.0327099 0.0303318 0.0327099 0.0319226 4.867470e-01 0.2513778 9.424965e-01 Syt17 up
26 CRYBB1 CRYBB1 -0.6315141 0.2924614 -2.159307 0.0308263 0.0275145 0.0308263 0.0323952 5.317860e-01 0.2997735 9.433667e-01 Crybb1 up
51 MEIG1 MEIG1 -1.5568552 0.7345368 -2.119506 0.0340477 0.0203682 0.0340477 0.0328155 2.107979e-01 0.0499606 8.894166e-01 Meig1 up
87 TRPC1 TRPC1 -0.9133696 0.4337654 -2.105676 0.0352325 0.0361240 0.0352325 0.0336084 4.011702e-01 0.1714379 9.387510e-01 Trpc1 up
88 TTLL11 TTLL11 1.6033388 0.7533240 2.128352 0.0333079 0.0457185 0.0333079 0.0338183 4.969597e+00 1.1352478 2.175463e+01 Ttll11 up
37 GRIA3 GRIA3 -0.5537059 0.2629723 -2.105567 0.0352420 0.0362229 0.0352420 0.0339876 5.748157e-01 0.3433098 9.624341e-01 Gria3 up
78 SPHKAP SPHKAP -0.3948747 0.1885112 -2.094701 0.0361976 0.0354954 0.0361976 0.0350410 6.737645e-01 0.4656365 9.749204e-01 Sphkap up
17 CES1 CES1 -1.2365117 0.6037801 -2.047950 0.0405649 0.0117912 0.0405649 0.0353114 2.903954e-01 0.0889306 9.482620e-01 Ces1d up
92 WNT4 WNT4 -0.8323685 0.4111895 -2.024294 0.0429399 0.0156938 0.0429399 0.0364697 4.350177e-01 0.1943130 9.738950e-01 Wnt4 up
29 FAM135B FAM135B -1.1288911 0.5417063 -2.083954 0.0371643 0.0296138 0.0371643 0.0366978 3.233917e-01 0.1118478 9.350398e-01 Fam135b up
57 NIPAL3 NIPAL3 0.3346470 0.1612557 2.075257 0.0379627 0.0390300 0.0379627 0.0369967 1.397447e+00 1.0187656 1.916887e+00 Nipal3 up
14 CCL27 CCL27 -8.0296337 4.5567387 -1.762145 0.0780448 0.0069579 0.0780448 0.0373252 3.257000e-04 0.0000000 2.463074e+00 Ccl27a up
54 MT3 MT3 0.3041427 0.1425664 2.133341 0.0328967 0.0234258 0.0328967 0.0395999 1.355462e+00 1.0250258 1.792422e+00 Mt3 up
47 LRRC6 LRRC6 -1.0838316 0.5327818 -2.034288 0.0419226 0.0388757 0.0419226 0.0396194 3.382968e-01 0.1190675 9.611754e-01 Lrrc6 up
81 TENM4 TENM4 -0.6701993 0.3295016 -2.033979 0.0419538 0.0392560 0.0419538 0.0413113 5.116066e-01 0.2682031 9.759070e-01 Tenm4 up
5 ALDOC ALDOC -0.3064586 0.1514231 -2.023857 0.0429849 0.0525149 0.0429849 0.0425914 7.360490e-01 0.5470351 9.903718e-01 Aldoc up
69 RAPGEF5 RAPGEF5 0.3193432 0.1604457 1.990350 0.0465524 0.0524216 0.0465524 0.0445547 1.376224e+00 1.0048872 1.884780e+00 Rapgef5 up
43 LDB3 LDB3 0.3834987 0.1921256 1.996083 0.0459248 0.0536589 0.0459248 0.0447002 1.467410e+00 1.0069636 2.138400e+00 Ldb3 up
33 GDF10 GDF10 -0.2476631 0.1253271 -1.976134 0.0481396 0.0394339 0.0481396 0.0457862 7.806229e-01 0.6106083 9.979755e-01 Gdf10 up
84 TPPP TPPP 0.2895090 0.1455712 1.988779 0.0467256 0.0504267 0.0467256 0.0459345 1.335771e+00 1.0042035 1.776817e+00 Tppp up
66 PPIL6 PPIL6 -0.8324625 0.4144059 -2.008809 0.0445573 0.0400225 0.0445573 0.0463260 4.349768e-01 0.1930737 9.799617e-01 Ppil6 up
23 CNTNAP4 CNTNAP4 0.4244264 0.2146225 1.977548 0.0479797 0.0526664 0.0479797 0.0466958 1.528713e+00 1.0037811 2.328161e+00 Cntnap4 up
31 FRY FRY -0.6944304 0.3511521 -1.977577 0.0479764 0.0486039 0.0479764 0.0472073 4.993588e-01 0.2509062 9.938342e-01 Fry up
41 IRX2 IRX2 -0.3255989 0.1648842 -1.974713 0.0483007 0.0587783 0.0483007 0.0477633 7.220948e-01 0.5226904 9.975711e-01 Irx2 down
11 CARTPT CARTPT 0.1630698 0.0843582 1.933065 0.0532282 0.0819939 0.0532282 0.0496218 1.177119e+00 0.9977334 1.388756e+00 Cartpt up
83 TMCO5A TMCO5A 82.6409564 43.6960941 1.891266 0.0585888 0.1037047 0.0585888 0.0498658 7.771616e+35 0.0496968 1.215330e+73 Tmco5 up

GBM_LGG

Gene-sets considered

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Table genes

Variable Term Beta StandardError Z P LRT Wald LogRank HR HRlower HRupper mm status
36 GPR139 GPR139 5.1595162 1.0707833 4.818450 0.0000014 0.0000396 0.0000014 0.0000000 1.740802e+02 21.3450416 1.419717e+03 Gpr139 up
61 PCDHGA3 PCDHGA3 0.7508024 0.2053482 3.656241 0.0002559 0.0025701 0.0002559 0.0000236 2.118699e+00 1.4166959 3.168560e+00 Pcdhga3 up
18 CHIC2 CHIC2 1.3148603 0.3211465 4.094269 0.0000424 0.0002660 0.0000424 0.0000446 3.724231e+00 1.9846144 6.988710e+00 Chic2 down
63 PHKG1 PHKG1 -0.6406674 0.1684263 -3.803845 0.0001425 0.0002338 0.0001425 0.0001123 5.269406e-01 0.3787887 7.330378e-01 Phkg1 up
3 ADAMTS3 ADAMTS3 3.2224925 1.0514520 3.064802 0.0021781 0.0093278 0.0021781 0.0001595 2.509058e+01 3.1953107 1.970191e+02 Adamts3 up
21 CLEC18A CLEC18A 2.8000255 0.7790372 3.594213 0.0003254 0.0014044 0.0003254 0.0001713 1.644507e+01 3.5720534 7.571001e+01 Clec18a up
46 LIX1 LIX1 -0.6899061 0.1972237 -3.498089 0.0004686 0.0005864 0.0004686 0.0003863 5.016232e-01 0.3408007 7.383372e-01 Lix1 up
72 SFTPC SFTPC 0.7150386 0.2109331 3.389884 0.0006992 0.0007212 0.0006992 0.0005360 2.044266e+00 1.3520438 3.090892e+00 Sftpc up
62 PCDHGA8 PCDHGA8 5.2362662 1.6538533 3.166101 0.0015450 0.0096278 0.0015450 0.0011135 1.879670e+02 7.3505362 4.806666e+03 Pcdhga8 up
93 ZBTB8B ZBTB8B 1.1365043 0.3520922 3.227860 0.0012472 0.0015945 0.0012472 0.0011193 3.115857e+00 1.5627018 6.212679e+00 Zbtb8b up
48 LRRK2 LRRK2 0.5470006 0.1760081 3.107815 0.0018848 0.0038480 0.0018848 0.0016209 1.728062e+00 1.2238861 2.439932e+00 Lrrk2 up
73 SH3GL2 SH3GL2 -0.7681192 0.2405062 -3.193760 0.0014043 0.0017402 0.0014043 0.0017373 4.638847e-01 0.2895282 7.432404e-01 Sh3gl2 up
56 MYH1 MYH1 6.4885350 2.3189710 2.798023 0.0051416 0.0245868 0.0051416 0.0019006 6.575594e+02 6.9826986 6.192224e+04 Myh1 up
10 BVES BVES 0.6492014 0.2109948 3.076860 0.0020919 0.0034852 0.0020919 0.0022376 1.914012e+00 1.2657428 2.894301e+00 Bves up
30 FAM186B FAM186B 3.6808737 1.2262259 3.001791 0.0026840 0.0048851 0.0026840 0.0028607 3.968105e+01 3.5877136 4.388828e+02 Fam186b up
77 SMIM1 SMIM1 0.8812849 0.3007913 2.929889 0.0033908 0.0049659 0.0033908 0.0032167 2.414000e+00 1.3387614 4.352825e+00 Smim1 up
4 AHCYL2 AHCYL2 -0.6577339 0.2262623 -2.906954 0.0036497 0.0028521 0.0036497 0.0033225 5.180239e-01 0.3324719 8.071320e-01 Ahcyl2 up
35 GLT8D2 GLT8D2 -2.1935510 0.7573641 -2.896297 0.0037760 0.0018451 0.0037760 0.0034438 1.115200e-01 0.0252746 4.920649e-01 Glt8d2 up
16 CEP135 CEP135 0.9612037 0.3279532 2.930917 0.0033796 0.0113210 0.0033796 0.0035540 2.614842e+00 1.3749635 4.972786e+00 Cep135 down
64 PLCXD1 PLCXD1 0.7187168 0.2420552 2.969226 0.0029855 0.0042069 0.0029855 0.0038072 2.051799e+00 1.2767238 3.297407e+00 Plcxd1 up
1 ABCA8 ABCA8 0.4570804 0.1554996 2.939431 0.0032882 0.0086596 0.0032882 0.0038081 1.579456e+00 1.1645174 2.142244e+00 Abca8b up
38 HHATL HHATL 0.3972220 0.1379059 2.880384 0.0039719 0.0037733 0.0039719 0.0039397 1.487686e+00 1.1353391 1.949383e+00 Hhatl up
19 CHRM5 CHRM5 1.9356194 0.6916367 2.798607 0.0051324 0.0113490 0.0051324 0.0039951 6.928334e+00 1.7861035 2.687516e+01 Chrm5 up
8 BARX2 BARX2 4.2196030 1.5075048 2.799064 0.0051251 0.0101462 0.0051251 0.0043039 6.800648e+01 3.5429083 1.305391e+03 Barx2 up
52 METTL11B METTL11B 2.5058448 0.9684965 2.587356 0.0096716 0.0338070 0.0096716 0.0050058 1.225391e+01 1.8360684 8.178248e+01 Mettl11b up
13 CCDC87 CCDC87 -0.6405216 0.2300130 -2.784719 0.0053574 0.0053539 0.0053574 0.0051444 5.270174e-01 0.3357666 8.272036e-01 Ccdc87 up
44 LGI3 LGI3 0.3468954 0.1262967 2.746671 0.0060204 0.0058834 0.0060204 0.0056087 1.414669e+00 1.1044621 1.812002e+00 Lgi3 up
90 TUB TUB -0.5353015 0.1944482 -2.752925 0.0059065 0.0069206 0.0059065 0.0057163 5.854927e-01 0.3999511 8.571092e-01 Tub up
74 SLC35F4 SLC35F4 7.7687589 3.3957542 2.287786 0.0221500 0.0864739 0.0221500 0.0063834 2.365534e+03 3.0440926 1.838232e+06 Slc35f4 up
85 TPSAB1 TPSAB1 -0.8846744 0.3542311 -2.497450 0.0125090 0.0006903 0.0125090 0.0063899 4.128486e-01 0.2061905 8.266333e-01 Tpsb2 down
39 HHIP HHIP 0.5059547 0.1893155 2.672548 0.0075278 0.0125895 0.0075278 0.0067012 1.658568e+00 1.1444259 2.403693e+00 Hhip up
25 CRTAC1 CRTAC1 -0.5325153 0.2040986 -2.609107 0.0090779 0.0096375 0.0090779 0.0088457 5.871263e-01 0.3935523 8.759123e-01 Crtac1 up
32 FXYD7 FXYD7 0.2876284 0.1121605 2.564436 0.0103343 0.0106282 0.0103343 0.0093643 1.333262e+00 1.0701490 1.661065e+00 Fxyd7 up
6 AOX3P AOX3P 11.3330802 4.4432645 2.550620 0.0107531 0.0331895 0.0107531 0.0097299 8.353995e+04 13.7968724 5.058337e+08 Aox3 up
76 SLCO4A1 SLCO4A1 0.5349134 0.2092046 2.556891 0.0105612 0.0149816 0.0105612 0.0103656 1.707300e+00 1.1330123 2.572677e+00 Slco4a1 up
91 VWC2 VWC2 -0.8658511 0.3444749 -2.513539 0.0119527 0.0076251 0.0119527 0.0104954 4.206934e-01 0.2141648 8.263865e-01 Vwc2 up
34 GLRA3 GLRA3 -0.7538191 0.3011341 -2.503267 0.0123053 0.0079996 0.0123053 0.0114512 4.705660e-01 0.2607922 8.490756e-01 Glra3 up
75 SLC8A3 SLC8A3 -0.6592973 0.2645167 -2.492460 0.0126862 0.0094084 0.0126862 0.0114866 5.172147e-01 0.3079738 8.686161e-01 Slc8a3 up
65 POPDC3 POPDC3 0.4728442 0.1902276 2.485676 0.0129306 0.0187433 0.0129306 0.0117812 1.604551e+00 1.1051763 2.329569e+00 Popdc3 up
86 TPSB2 TPSB2 -0.8013200 0.3290348 -2.435365 0.0148768 0.0022816 0.0148768 0.0118109 4.487363e-01 0.2354595 8.551968e-01 Tpsb2 down
58 NLRP6 NLRP6 0.6709421 0.2702415 2.482750 0.0130373 0.0218135 0.0130373 0.0125357 1.956079e+00 1.1517453 3.322128e+00 Nlrp6 up
60 PCDH7 PCDH7 -0.6628942 0.2660821 -2.491314 0.0127271 0.0104717 0.0127271 0.0125628 5.153577e-01 0.3059280 8.681569e-01 Pcdh7 up
24 CPA3 CPA3 -3.5762611 1.9488975 -1.835017 0.0665031 0.0007919 0.0665031 0.0136850 2.798010e-02 0.0006137 1.275716e+00 Cpa3 down
15 CDH7 CDH7 -0.8340137 0.3472870 -2.401512 0.0163275 0.0091114 0.0163275 0.0140317 4.343026e-01 0.2198777 8.578348e-01 Cdh7 up
2 ABLIM3 ABLIM3 -0.4808436 0.1974873 -2.434808 0.0148997 0.0152889 0.0148997 0.0144433 6.182616e-01 0.4198275 9.104870e-01 Ablim3 up
9 BMP3 BMP3 1.3553265 0.5709786 2.373690 0.0176113 0.0373274 0.0176113 0.0148387 3.878027e+00 1.2664643 1.187487e+01 Bmp3 up
45 LIPG LIPG -0.5180286 0.2142283 -2.418115 0.0156012 0.0156964 0.0156012 0.0151243 5.956937e-01 0.3914458 9.065139e-01 Lipg up
20 CHST15 CHST15 -0.5033978 0.2093893 -2.404124 0.0162113 0.0171423 0.0162113 0.0158504 6.044733e-01 0.4010002 9.111914e-01 Chst15 up
50 MAP6D1 MAP6D1 0.3774339 0.1582533 2.384999 0.0170792 0.0189951 0.0170792 0.0161717 1.458537e+00 1.0695770 1.988946e+00 Map6d1 up
67 PPP2R2B PPP2R2B -0.8738006 0.3636238 -2.403035 0.0162596 0.0143470 0.0162596 0.0162598 4.173623e-01 0.2046426 8.511975e-01 Ppp2r2b up
53 MGAT4C MGAT4C -1.3967395 0.5768181 -2.421456 0.0154585 0.0077684 0.0154585 0.0173673 2.474023e-01 0.0798758 7.662883e-01 Mgat4c up
49 LUZP2 LUZP2 -0.5286152 0.2259100 -2.339937 0.0192870 0.0215066 0.0192870 0.0185859 5.894206e-01 0.3785562 9.177414e-01 Luzp2 up
22 CLMN CLMN 0.6592381 0.2808949 2.346921 0.0189293 0.0300935 0.0189293 0.0196584 1.933319e+00 1.1148214 3.352753e+00 Clmn up
79 SPOCK3 SPOCK3 0.5432691 0.2349925 2.311857 0.0207855 0.0283806 0.0207855 0.0197538 1.721626e+00 1.0862075 2.728756e+00 Spock3 up
70 RNF32 RNF32 -0.8573740 0.3707326 -2.312648 0.0207420 0.0208589 0.0207420 0.0203103 4.242748e-01 0.2051536 8.774358e-01 Rnf32 up
59 NSUN7 NSUN7 3.4739776 1.5269652 2.275086 0.0229008 0.0292430 0.0229008 0.0214978 3.226482e+01 1.6179837 6.434050e+02 Nsun7 up
89 TTLL7 TTLL7 0.5323731 0.2360615 2.255231 0.0241189 0.0273676 0.0241189 0.0242335 1.702969e+00 1.0721876 2.704847e+00 Ttll7 up
7 ARHGAP8 ARHGAP8 20.8761762 9.4024620 2.220288 0.0263992 0.0399771 0.0263992 0.0246239 1.165220e+09 11.5616004 1.174352e+17 Arhgap8 down
82 TGM3 TGM3 -4.2363329 1.9422468 -2.181151 0.0291723 0.0073239 0.0291723 0.0251856 1.446050e-02 0.0003213 6.507699e-01 Tgm3 up
71 SERINC2 SERINC2 0.4735774 0.2137832 2.215223 0.0267448 0.0318912 0.0267448 0.0261266 1.605728e+00 1.0560865 2.441432e+00 Serinc2 up
55 MUSK MUSK 14.1949811 6.5867212 2.155091 0.0311547 0.0678555 0.0311547 0.0279285 1.461511e+06 3.6155532 5.907847e+11 Musk up
12 CCDC74B CCDC74B -0.5455931 0.2493796 -2.187802 0.0286840 0.0294507 0.0286840 0.0283321 5.794980e-01 0.3554509 9.447659e-01 Ccdc74a up
42 KCNG1 KCNG1 -0.4093191 0.1876366 -2.181446 0.0291504 0.0208728 0.0291504 0.0291734 6.641023e-01 0.4597465 9.592936e-01 Kcng1 up
28 FAM110B FAM110B -0.4469752 0.2066142 -2.163333 0.0305156 0.0322178 0.0305156 0.0297200 6.395597e-01 0.4265901 9.588517e-01 Fam110b up
68 PRSS35 PRSS35 -0.2598632 0.1208744 -2.149861 0.0315662 0.0362531 0.0315662 0.0299232 7.711571e-01 0.6084913 9.773077e-01 Prss35 up
27 EFCAB6 EFCAB6 -4.6697434 2.1733079 -2.148680 0.0316598 0.0230073 0.0316598 0.0302239 9.374700e-03 0.0001324 6.635586e-01 Efcab6 up
40 INHBA INHBA -0.7294275 0.3291556 -2.216057 0.0266876 0.0184006 0.0266876 0.0302935 4.821850e-01 0.2529507 9.191606e-01 Inhba up
80 SYT17 SYT17 -0.7200108 0.3371428 -2.135626 0.0327099 0.0303318 0.0327099 0.0319226 4.867470e-01 0.2513778 9.424965e-01 Syt17 up
26 CRYBB1 CRYBB1 -0.6315141 0.2924614 -2.159307 0.0308263 0.0275145 0.0308263 0.0323952 5.317860e-01 0.2997735 9.433667e-01 Crybb1 up
51 MEIG1 MEIG1 -1.5568552 0.7345368 -2.119506 0.0340477 0.0203682 0.0340477 0.0328155 2.107979e-01 0.0499606 8.894166e-01 Meig1 up
87 TRPC1 TRPC1 -0.9133696 0.4337654 -2.105676 0.0352325 0.0361240 0.0352325 0.0336084 4.011702e-01 0.1714379 9.387510e-01 Trpc1 up
88 TTLL11 TTLL11 1.6033388 0.7533240 2.128352 0.0333079 0.0457185 0.0333079 0.0338183 4.969597e+00 1.1352478 2.175463e+01 Ttll11 up
37 GRIA3 GRIA3 -0.5537059 0.2629723 -2.105567 0.0352420 0.0362229 0.0352420 0.0339876 5.748157e-01 0.3433098 9.624341e-01 Gria3 up
78 SPHKAP SPHKAP -0.3948747 0.1885112 -2.094701 0.0361976 0.0354954 0.0361976 0.0350410 6.737645e-01 0.4656365 9.749204e-01 Sphkap up
17 CES1 CES1 -1.2365117 0.6037801 -2.047950 0.0405649 0.0117912 0.0405649 0.0353114 2.903954e-01 0.0889306 9.482620e-01 Ces1d up
92 WNT4 WNT4 -0.8323685 0.4111895 -2.024294 0.0429399 0.0156938 0.0429399 0.0364697 4.350177e-01 0.1943130 9.738950e-01 Wnt4 up
29 FAM135B FAM135B -1.1288911 0.5417063 -2.083954 0.0371643 0.0296138 0.0371643 0.0366978 3.233917e-01 0.1118478 9.350398e-01 Fam135b up
57 NIPAL3 NIPAL3 0.3346470 0.1612557 2.075257 0.0379627 0.0390300 0.0379627 0.0369967 1.397447e+00 1.0187656 1.916887e+00 Nipal3 up
14 CCL27 CCL27 -8.0296337 4.5567387 -1.762145 0.0780448 0.0069579 0.0780448 0.0373252 3.257000e-04 0.0000000 2.463074e+00 Ccl27a up
54 MT3 MT3 0.3041427 0.1425664 2.133341 0.0328967 0.0234258 0.0328967 0.0395999 1.355462e+00 1.0250258 1.792422e+00 Mt3 up
47 LRRC6 LRRC6 -1.0838316 0.5327818 -2.034288 0.0419226 0.0388757 0.0419226 0.0396194 3.382968e-01 0.1190675 9.611754e-01 Lrrc6 up
81 TENM4 TENM4 -0.6701993 0.3295016 -2.033979 0.0419538 0.0392560 0.0419538 0.0413113 5.116066e-01 0.2682031 9.759070e-01 Tenm4 up
5 ALDOC ALDOC -0.3064586 0.1514231 -2.023857 0.0429849 0.0525149 0.0429849 0.0425914 7.360490e-01 0.5470351 9.903718e-01 Aldoc up
69 RAPGEF5 RAPGEF5 0.3193432 0.1604457 1.990350 0.0465524 0.0524216 0.0465524 0.0445547 1.376224e+00 1.0048872 1.884780e+00 Rapgef5 up
43 LDB3 LDB3 0.3834987 0.1921256 1.996083 0.0459248 0.0536589 0.0459248 0.0447002 1.467410e+00 1.0069636 2.138400e+00 Ldb3 up
33 GDF10 GDF10 -0.2476631 0.1253271 -1.976134 0.0481396 0.0394339 0.0481396 0.0457862 7.806229e-01 0.6106083 9.979755e-01 Gdf10 up
84 TPPP TPPP 0.2895090 0.1455712 1.988779 0.0467256 0.0504267 0.0467256 0.0459345 1.335771e+00 1.0042035 1.776817e+00 Tppp up
66 PPIL6 PPIL6 -0.8324625 0.4144059 -2.008809 0.0445573 0.0400225 0.0445573 0.0463260 4.349768e-01 0.1930737 9.799617e-01 Ppil6 up
23 CNTNAP4 CNTNAP4 0.4244264 0.2146225 1.977548 0.0479797 0.0526664 0.0479797 0.0466958 1.528713e+00 1.0037811 2.328161e+00 Cntnap4 up
31 FRY FRY -0.6944304 0.3511521 -1.977577 0.0479764 0.0486039 0.0479764 0.0472073 4.993588e-01 0.2509062 9.938342e-01 Fry up
41 IRX2 IRX2 -0.3255989 0.1648842 -1.974713 0.0483007 0.0587783 0.0483007 0.0477633 7.220948e-01 0.5226904 9.975711e-01 Irx2 down
11 CARTPT CARTPT 0.1630698 0.0843582 1.933065 0.0532282 0.0819939 0.0532282 0.0496218 1.177119e+00 0.9977334 1.388756e+00 Cartpt up
83 TMCO5A TMCO5A 82.6409564 43.6960941 1.891266 0.0585888 0.1037047 0.0585888 0.0498658 7.771616e+35 0.0496968 1.215330e+73 Tmco5 up

only GBM

Gene-sets considered

UP and DOWN

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Table genes

Variable Term Beta StandardError Z P LRT Wald LogRank HR HRlower HRupper mm status
36 GPR139 GPR139 5.1595162 1.0707833 4.818450 0.0000014 0.0000396 0.0000014 0.0000000 1.740802e+02 21.3450416 1.419717e+03 Gpr139 up
61 PCDHGA3 PCDHGA3 0.7508024 0.2053482 3.656241 0.0002559 0.0025701 0.0002559 0.0000236 2.118699e+00 1.4166959 3.168560e+00 Pcdhga3 up
18 CHIC2 CHIC2 1.3148603 0.3211465 4.094269 0.0000424 0.0002660 0.0000424 0.0000446 3.724231e+00 1.9846144 6.988710e+00 Chic2 down
63 PHKG1 PHKG1 -0.6406674 0.1684263 -3.803845 0.0001425 0.0002338 0.0001425 0.0001123 5.269406e-01 0.3787887 7.330378e-01 Phkg1 up
3 ADAMTS3 ADAMTS3 3.2224925 1.0514520 3.064802 0.0021781 0.0093278 0.0021781 0.0001595 2.509058e+01 3.1953107 1.970191e+02 Adamts3 up
21 CLEC18A CLEC18A 2.8000255 0.7790372 3.594213 0.0003254 0.0014044 0.0003254 0.0001713 1.644507e+01 3.5720534 7.571001e+01 Clec18a up
46 LIX1 LIX1 -0.6899061 0.1972237 -3.498089 0.0004686 0.0005864 0.0004686 0.0003863 5.016232e-01 0.3408007 7.383372e-01 Lix1 up
72 SFTPC SFTPC 0.7150386 0.2109331 3.389884 0.0006992 0.0007212 0.0006992 0.0005360 2.044266e+00 1.3520438 3.090892e+00 Sftpc up
62 PCDHGA8 PCDHGA8 5.2362662 1.6538533 3.166101 0.0015450 0.0096278 0.0015450 0.0011135 1.879670e+02 7.3505362 4.806666e+03 Pcdhga8 up
93 ZBTB8B ZBTB8B 1.1365043 0.3520922 3.227860 0.0012472 0.0015945 0.0012472 0.0011193 3.115857e+00 1.5627018 6.212679e+00 Zbtb8b up
48 LRRK2 LRRK2 0.5470006 0.1760081 3.107815 0.0018848 0.0038480 0.0018848 0.0016209 1.728062e+00 1.2238861 2.439932e+00 Lrrk2 up
73 SH3GL2 SH3GL2 -0.7681192 0.2405062 -3.193760 0.0014043 0.0017402 0.0014043 0.0017373 4.638847e-01 0.2895282 7.432404e-01 Sh3gl2 up
56 MYH1 MYH1 6.4885350 2.3189710 2.798023 0.0051416 0.0245868 0.0051416 0.0019006 6.575594e+02 6.9826986 6.192224e+04 Myh1 up
10 BVES BVES 0.6492014 0.2109948 3.076860 0.0020919 0.0034852 0.0020919 0.0022376 1.914012e+00 1.2657428 2.894301e+00 Bves up
30 FAM186B FAM186B 3.6808737 1.2262259 3.001791 0.0026840 0.0048851 0.0026840 0.0028607 3.968105e+01 3.5877136 4.388828e+02 Fam186b up
77 SMIM1 SMIM1 0.8812849 0.3007913 2.929889 0.0033908 0.0049659 0.0033908 0.0032167 2.414000e+00 1.3387614 4.352825e+00 Smim1 up
4 AHCYL2 AHCYL2 -0.6577339 0.2262623 -2.906954 0.0036497 0.0028521 0.0036497 0.0033225 5.180239e-01 0.3324719 8.071320e-01 Ahcyl2 up
35 GLT8D2 GLT8D2 -2.1935510 0.7573641 -2.896297 0.0037760 0.0018451 0.0037760 0.0034438 1.115200e-01 0.0252746 4.920649e-01 Glt8d2 up
16 CEP135 CEP135 0.9612037 0.3279532 2.930917 0.0033796 0.0113210 0.0033796 0.0035540 2.614842e+00 1.3749635 4.972786e+00 Cep135 down
64 PLCXD1 PLCXD1 0.7187168 0.2420552 2.969226 0.0029855 0.0042069 0.0029855 0.0038072 2.051799e+00 1.2767238 3.297407e+00 Plcxd1 up
1 ABCA8 ABCA8 0.4570804 0.1554996 2.939431 0.0032882 0.0086596 0.0032882 0.0038081 1.579456e+00 1.1645174 2.142244e+00 Abca8b up
38 HHATL HHATL 0.3972220 0.1379059 2.880384 0.0039719 0.0037733 0.0039719 0.0039397 1.487686e+00 1.1353391 1.949383e+00 Hhatl up
19 CHRM5 CHRM5 1.9356194 0.6916367 2.798607 0.0051324 0.0113490 0.0051324 0.0039951 6.928334e+00 1.7861035 2.687516e+01 Chrm5 up
8 BARX2 BARX2 4.2196030 1.5075048 2.799064 0.0051251 0.0101462 0.0051251 0.0043039 6.800648e+01 3.5429083 1.305391e+03 Barx2 up
52 METTL11B METTL11B 2.5058448 0.9684965 2.587356 0.0096716 0.0338070 0.0096716 0.0050058 1.225391e+01 1.8360684 8.178248e+01 Mettl11b up
13 CCDC87 CCDC87 -0.6405216 0.2300130 -2.784719 0.0053574 0.0053539 0.0053574 0.0051444 5.270174e-01 0.3357666 8.272036e-01 Ccdc87 up
44 LGI3 LGI3 0.3468954 0.1262967 2.746671 0.0060204 0.0058834 0.0060204 0.0056087 1.414669e+00 1.1044621 1.812002e+00 Lgi3 up
90 TUB TUB -0.5353015 0.1944482 -2.752925 0.0059065 0.0069206 0.0059065 0.0057163 5.854927e-01 0.3999511 8.571092e-01 Tub up
74 SLC35F4 SLC35F4 7.7687589 3.3957542 2.287786 0.0221500 0.0864739 0.0221500 0.0063834 2.365534e+03 3.0440926 1.838232e+06 Slc35f4 up
85 TPSAB1 TPSAB1 -0.8846744 0.3542311 -2.497450 0.0125090 0.0006903 0.0125090 0.0063899 4.128486e-01 0.2061905 8.266333e-01 Tpsb2 down
39 HHIP HHIP 0.5059547 0.1893155 2.672548 0.0075278 0.0125895 0.0075278 0.0067012 1.658568e+00 1.1444259 2.403693e+00 Hhip up
25 CRTAC1 CRTAC1 -0.5325153 0.2040986 -2.609107 0.0090779 0.0096375 0.0090779 0.0088457 5.871263e-01 0.3935523 8.759123e-01 Crtac1 up
32 FXYD7 FXYD7 0.2876284 0.1121605 2.564436 0.0103343 0.0106282 0.0103343 0.0093643 1.333262e+00 1.0701490 1.661065e+00 Fxyd7 up
6 AOX3P AOX3P 11.3330802 4.4432645 2.550620 0.0107531 0.0331895 0.0107531 0.0097299 8.353995e+04 13.7968724 5.058337e+08 Aox3 up
76 SLCO4A1 SLCO4A1 0.5349134 0.2092046 2.556891 0.0105612 0.0149816 0.0105612 0.0103656 1.707300e+00 1.1330123 2.572677e+00 Slco4a1 up
91 VWC2 VWC2 -0.8658511 0.3444749 -2.513539 0.0119527 0.0076251 0.0119527 0.0104954 4.206934e-01 0.2141648 8.263865e-01 Vwc2 up
34 GLRA3 GLRA3 -0.7538191 0.3011341 -2.503267 0.0123053 0.0079996 0.0123053 0.0114512 4.705660e-01 0.2607922 8.490756e-01 Glra3 up
75 SLC8A3 SLC8A3 -0.6592973 0.2645167 -2.492460 0.0126862 0.0094084 0.0126862 0.0114866 5.172147e-01 0.3079738 8.686161e-01 Slc8a3 up
65 POPDC3 POPDC3 0.4728442 0.1902276 2.485676 0.0129306 0.0187433 0.0129306 0.0117812 1.604551e+00 1.1051763 2.329569e+00 Popdc3 up
86 TPSB2 TPSB2 -0.8013200 0.3290348 -2.435365 0.0148768 0.0022816 0.0148768 0.0118109 4.487363e-01 0.2354595 8.551968e-01 Tpsb2 down
58 NLRP6 NLRP6 0.6709421 0.2702415 2.482750 0.0130373 0.0218135 0.0130373 0.0125357 1.956079e+00 1.1517453 3.322128e+00 Nlrp6 up
60 PCDH7 PCDH7 -0.6628942 0.2660821 -2.491314 0.0127271 0.0104717 0.0127271 0.0125628 5.153577e-01 0.3059280 8.681569e-01 Pcdh7 up
24 CPA3 CPA3 -3.5762611 1.9488975 -1.835017 0.0665031 0.0007919 0.0665031 0.0136850 2.798010e-02 0.0006137 1.275716e+00 Cpa3 down
15 CDH7 CDH7 -0.8340137 0.3472870 -2.401512 0.0163275 0.0091114 0.0163275 0.0140317 4.343026e-01 0.2198777 8.578348e-01 Cdh7 up
2 ABLIM3 ABLIM3 -0.4808436 0.1974873 -2.434808 0.0148997 0.0152889 0.0148997 0.0144433 6.182616e-01 0.4198275 9.104870e-01 Ablim3 up
9 BMP3 BMP3 1.3553265 0.5709786 2.373690 0.0176113 0.0373274 0.0176113 0.0148387 3.878027e+00 1.2664643 1.187487e+01 Bmp3 up
45 LIPG LIPG -0.5180286 0.2142283 -2.418115 0.0156012 0.0156964 0.0156012 0.0151243 5.956937e-01 0.3914458 9.065139e-01 Lipg up
20 CHST15 CHST15 -0.5033978 0.2093893 -2.404124 0.0162113 0.0171423 0.0162113 0.0158504 6.044733e-01 0.4010002 9.111914e-01 Chst15 up
50 MAP6D1 MAP6D1 0.3774339 0.1582533 2.384999 0.0170792 0.0189951 0.0170792 0.0161717 1.458537e+00 1.0695770 1.988946e+00 Map6d1 up
67 PPP2R2B PPP2R2B -0.8738006 0.3636238 -2.403035 0.0162596 0.0143470 0.0162596 0.0162598 4.173623e-01 0.2046426 8.511975e-01 Ppp2r2b up
53 MGAT4C MGAT4C -1.3967395 0.5768181 -2.421456 0.0154585 0.0077684 0.0154585 0.0173673 2.474023e-01 0.0798758 7.662883e-01 Mgat4c up
49 LUZP2 LUZP2 -0.5286152 0.2259100 -2.339937 0.0192870 0.0215066 0.0192870 0.0185859 5.894206e-01 0.3785562 9.177414e-01 Luzp2 up
22 CLMN CLMN 0.6592381 0.2808949 2.346921 0.0189293 0.0300935 0.0189293 0.0196584 1.933319e+00 1.1148214 3.352753e+00 Clmn up
79 SPOCK3 SPOCK3 0.5432691 0.2349925 2.311857 0.0207855 0.0283806 0.0207855 0.0197538 1.721626e+00 1.0862075 2.728756e+00 Spock3 up
70 RNF32 RNF32 -0.8573740 0.3707326 -2.312648 0.0207420 0.0208589 0.0207420 0.0203103 4.242748e-01 0.2051536 8.774358e-01 Rnf32 up
59 NSUN7 NSUN7 3.4739776 1.5269652 2.275086 0.0229008 0.0292430 0.0229008 0.0214978 3.226482e+01 1.6179837 6.434050e+02 Nsun7 up
89 TTLL7 TTLL7 0.5323731 0.2360615 2.255231 0.0241189 0.0273676 0.0241189 0.0242335 1.702969e+00 1.0721876 2.704847e+00 Ttll7 up
7 ARHGAP8 ARHGAP8 20.8761762 9.4024620 2.220288 0.0263992 0.0399771 0.0263992 0.0246239 1.165220e+09 11.5616004 1.174352e+17 Arhgap8 down
82 TGM3 TGM3 -4.2363329 1.9422468 -2.181151 0.0291723 0.0073239 0.0291723 0.0251856 1.446050e-02 0.0003213 6.507699e-01 Tgm3 up
71 SERINC2 SERINC2 0.4735774 0.2137832 2.215223 0.0267448 0.0318912 0.0267448 0.0261266 1.605728e+00 1.0560865 2.441432e+00 Serinc2 up
55 MUSK MUSK 14.1949811 6.5867212 2.155091 0.0311547 0.0678555 0.0311547 0.0279285 1.461511e+06 3.6155532 5.907847e+11 Musk up
12 CCDC74B CCDC74B -0.5455931 0.2493796 -2.187802 0.0286840 0.0294507 0.0286840 0.0283321 5.794980e-01 0.3554509 9.447659e-01 Ccdc74a up
42 KCNG1 KCNG1 -0.4093191 0.1876366 -2.181446 0.0291504 0.0208728 0.0291504 0.0291734 6.641023e-01 0.4597465 9.592936e-01 Kcng1 up
28 FAM110B FAM110B -0.4469752 0.2066142 -2.163333 0.0305156 0.0322178 0.0305156 0.0297200 6.395597e-01 0.4265901 9.588517e-01 Fam110b up
68 PRSS35 PRSS35 -0.2598632 0.1208744 -2.149861 0.0315662 0.0362531 0.0315662 0.0299232 7.711571e-01 0.6084913 9.773077e-01 Prss35 up
27 EFCAB6 EFCAB6 -4.6697434 2.1733079 -2.148680 0.0316598 0.0230073 0.0316598 0.0302239 9.374700e-03 0.0001324 6.635586e-01 Efcab6 up
40 INHBA INHBA -0.7294275 0.3291556 -2.216057 0.0266876 0.0184006 0.0266876 0.0302935 4.821850e-01 0.2529507 9.191606e-01 Inhba up
80 SYT17 SYT17 -0.7200108 0.3371428 -2.135626 0.0327099 0.0303318 0.0327099 0.0319226 4.867470e-01 0.2513778 9.424965e-01 Syt17 up
26 CRYBB1 CRYBB1 -0.6315141 0.2924614 -2.159307 0.0308263 0.0275145 0.0308263 0.0323952 5.317860e-01 0.2997735 9.433667e-01 Crybb1 up
51 MEIG1 MEIG1 -1.5568552 0.7345368 -2.119506 0.0340477 0.0203682 0.0340477 0.0328155 2.107979e-01 0.0499606 8.894166e-01 Meig1 up
87 TRPC1 TRPC1 -0.9133696 0.4337654 -2.105676 0.0352325 0.0361240 0.0352325 0.0336084 4.011702e-01 0.1714379 9.387510e-01 Trpc1 up
88 TTLL11 TTLL11 1.6033388 0.7533240 2.128352 0.0333079 0.0457185 0.0333079 0.0338183 4.969597e+00 1.1352478 2.175463e+01 Ttll11 up
37 GRIA3 GRIA3 -0.5537059 0.2629723 -2.105567 0.0352420 0.0362229 0.0352420 0.0339876 5.748157e-01 0.3433098 9.624341e-01 Gria3 up
78 SPHKAP SPHKAP -0.3948747 0.1885112 -2.094701 0.0361976 0.0354954 0.0361976 0.0350410 6.737645e-01 0.4656365 9.749204e-01 Sphkap up
17 CES1 CES1 -1.2365117 0.6037801 -2.047950 0.0405649 0.0117912 0.0405649 0.0353114 2.903954e-01 0.0889306 9.482620e-01 Ces1d up
92 WNT4 WNT4 -0.8323685 0.4111895 -2.024294 0.0429399 0.0156938 0.0429399 0.0364697 4.350177e-01 0.1943130 9.738950e-01 Wnt4 up
29 FAM135B FAM135B -1.1288911 0.5417063 -2.083954 0.0371643 0.0296138 0.0371643 0.0366978 3.233917e-01 0.1118478 9.350398e-01 Fam135b up
57 NIPAL3 NIPAL3 0.3346470 0.1612557 2.075257 0.0379627 0.0390300 0.0379627 0.0369967 1.397447e+00 1.0187656 1.916887e+00 Nipal3 up
14 CCL27 CCL27 -8.0296337 4.5567387 -1.762145 0.0780448 0.0069579 0.0780448 0.0373252 3.257000e-04 0.0000000 2.463074e+00 Ccl27a up
54 MT3 MT3 0.3041427 0.1425664 2.133341 0.0328967 0.0234258 0.0328967 0.0395999 1.355462e+00 1.0250258 1.792422e+00 Mt3 up
47 LRRC6 LRRC6 -1.0838316 0.5327818 -2.034288 0.0419226 0.0388757 0.0419226 0.0396194 3.382968e-01 0.1190675 9.611754e-01 Lrrc6 up
81 TENM4 TENM4 -0.6701993 0.3295016 -2.033979 0.0419538 0.0392560 0.0419538 0.0413113 5.116066e-01 0.2682031 9.759070e-01 Tenm4 up
5 ALDOC ALDOC -0.3064586 0.1514231 -2.023857 0.0429849 0.0525149 0.0429849 0.0425914 7.360490e-01 0.5470351 9.903718e-01 Aldoc up
69 RAPGEF5 RAPGEF5 0.3193432 0.1604457 1.990350 0.0465524 0.0524216 0.0465524 0.0445547 1.376224e+00 1.0048872 1.884780e+00 Rapgef5 up
43 LDB3 LDB3 0.3834987 0.1921256 1.996083 0.0459248 0.0536589 0.0459248 0.0447002 1.467410e+00 1.0069636 2.138400e+00 Ldb3 up
33 GDF10 GDF10 -0.2476631 0.1253271 -1.976134 0.0481396 0.0394339 0.0481396 0.0457862 7.806229e-01 0.6106083 9.979755e-01 Gdf10 up
84 TPPP TPPP 0.2895090 0.1455712 1.988779 0.0467256 0.0504267 0.0467256 0.0459345 1.335771e+00 1.0042035 1.776817e+00 Tppp up
66 PPIL6 PPIL6 -0.8324625 0.4144059 -2.008809 0.0445573 0.0400225 0.0445573 0.0463260 4.349768e-01 0.1930737 9.799617e-01 Ppil6 up
23 CNTNAP4 CNTNAP4 0.4244264 0.2146225 1.977548 0.0479797 0.0526664 0.0479797 0.0466958 1.528713e+00 1.0037811 2.328161e+00 Cntnap4 up
31 FRY FRY -0.6944304 0.3511521 -1.977577 0.0479764 0.0486039 0.0479764 0.0472073 4.993588e-01 0.2509062 9.938342e-01 Fry up
41 IRX2 IRX2 -0.3255989 0.1648842 -1.974713 0.0483007 0.0587783 0.0483007 0.0477633 7.220948e-01 0.5226904 9.975711e-01 Irx2 down
11 CARTPT CARTPT 0.1630698 0.0843582 1.933065 0.0532282 0.0819939 0.0532282 0.0496218 1.177119e+00 0.9977334 1.388756e+00 Cartpt up
83 TMCO5A TMCO5A 82.6409564 43.6960941 1.891266 0.0585888 0.1037047 0.0585888 0.0498658 7.771616e+35 0.0496968 1.215330e+73 Tmco5 up